Ethyl 4-methylenecyclohexanecarboxylate
- CAS No.
- 145576-28-9
- Chemical Name:
- Ethyl 4-methylenecyclohexanecarboxylate
- Synonyms
- ethyl 4-methylenecyclohexane-1-carboxylate;Ethyl 4-methylenecyclohexanecarboxylate;ethyl 4-methylidenecyclohexanecarboxylate;cyclohexanecarboxylic methylene acid ethyl ester;4-Methylene-cyclohexanecarboxylic acid ethyl ester;Cyclohexanecarboxylic acid, 4-methylene-, ethyl ester
- CBNumber:
- CB72482018
- Molecular Formula:
- C10H16O2
- Molecular Weight:
- 168.23
- MDL Number:
- MFCD12498694
- MOL File:
- 145576-28-9.mol
- MSDS File:
- SDS
| Boiling point | 47°/0.7mm |
|---|---|
| Density | 0.96±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C10H16O2/c1-3-12-10(11)9-6-4-8(2)5-7-9/h9H,2-7H2,1H3 |
| InChIKey | DLVGFWIRQAUWDC-UHFFFAOYSA-N |
| SMILES | C1(C(OCC)=O)CCC(=C)CC1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| HazardClass | IRRITANT |
| HS Code | 2916200090 |
Ethyl 4-methylenecyclohexanecarboxylate price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | VFA57628 | Ethyl 4-methylenecyclohexanecarboxylate | 145576-28-9 | 10g | $324.5 | 2026-06-05 | Buy |
| Biosynth | VFA57628 | Ethyl 4-methylenecyclohexanecarboxylate | 145576-28-9 | 25g | $649 | 2026-06-05 | Buy |
| Biosynth | VFA57628 | Ethyl 4-methylenecyclohexanecarboxylate | 145576-28-9 | 50g | $908.5 | 2026-06-05 | Buy |
| Biosynth | VFA57628 | Ethyl 4-methylenecyclohexanecarboxylate | 145576-28-9 | 100g | $1298 | 2026-06-05 | Buy |
| Apolloscientific | OR960267 | Ethyl 4-methylidenecyclohexane-1-carboxylate 98% | 145576-28-9 | 100mg | $21 | 2026-06-04 | Buy |
Ethyl 4-methylenecyclohexanecarboxylate Chemical Properties, Uses, Production
Synthesis
17159-79-4
1779-49-3
145576-28-9
A. General procedure for the synthesis of ethyl 4-methylenecyclohexanecarboxylate: n-butyllithium (9.07 mL, 14.51 mmol) was slowly added to a solution of methyltriphenylphosphonium bromide (5.18 g, 14.51 mmol) in tetrahydrofuran (THF, 50 mL) at 0 °C. The reaction mixture was stirred at 0 °C for 30 min. Subsequently, a solution of ethyl 4-oxocyclohexanecarboxylate (1.9 g, 11.16 mmol) in THF (8 mL) was added dropwise at the same temperature. The reaction system was gradually warmed up to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride (NH4Cl) and diluted with ethyl acetate (EtOAc). The organic layer was separated, washed sequentially with water and brine, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel (SiO2) with an eluent gradient of 0 to 50% ethyl acetate/hexane to afford the title compound, ethyl 4-methylenecyclohexanecarboxylate (1.58 g, 84% yield), as a colorless oil.1H NMR (500 MHz, CDCl3) δ 4.65 (s, 2H), 4.17-4.11 (m, 2H), and 2.44 (tt, J = 11.1, 3.8 Hz, 1H), 2.35 (dt, J = 13.7, 4.0 Hz, 2H), 2.11-1.96 (m, 4H), 1.64-1.54 (m, 2H), 1.28-1.23 (m, 3H).
References
[1] Patent: EP2738156, 2014, A1. Location in patent: Paragraph 0124-0125
[2] Patent: US2014/179638, 2014, A1. Location in patent: Page/Page column
[3] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 21, p. 5719 - 5725
[4] Patent: WO2012/142237, 2012, A1. Location in patent: Page/Page column 94
[5] Patent: US2014/275173, 2014, A1. Location in patent: Paragraph 0421
Ethyl 4-methylenecyclohexanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Renyi New Materials Technology Co., Ltd | 13306222239 | wangmeili@renyiam.com | China | 558 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| skychemical Co.Ltd | 021-20958197 20965099 | sales@skychemical.com | China | 1182 | 57 |
| Aloespharm Co., Ltd. | 021-20960837 | market@aloespharm.com | China | 1299 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Shanghai YuanQi Biotechnology Co., Ltd. | +86-2332782371 +86-18120098618 | sales@adobechem.com | China | 1250 | 50 |
| DebyeTec.com Inc. | 18086626237 18086626237 | 2693528373@qq.com | China | 2936 | 56 |
View Latest Price from Ethyl 4-methylenecyclohexanecarboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | cyclohexanecarboxylic methylene acid ethyl ester
145576-28-9
|
100gm | 96% | 1kgs | Shanghai Yongzeng Technology Co.,Ltd |
-
- cyclohexanecarboxylic methylene acid ethyl ester
145576-28-9
- $0.00
- 96%
- Shanghai Yongzeng Technology Co.,Ltd
