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Methyltriphenylphosphonium bromide

Methyltriphenylphosphonium bromide structure

CAS No.: 1779-49-3

Chemical Name:: Methyltriphenylphosphonium bromide

Synonyms: TRIPHENYLMETHYLPHOSPHONIUM BROMIDE;MTPPB;Methyltriphenylphosphanium bromide;Methyltriphenylphosphine bromide;Bromo(methyl)triphenylphosphorane;Methyl Triphenyl Phosphonium Bromide (MTPBB);MTPBr;MePPh3Br;Methyl triphenyl pho;Methy triphenylphosphonium

CBNumber:: CB1137882

Molecular Formula:: C19H18P.Br

Molecular Weight:: 357.22

MDL Number:: MFCD00011804

MOL File:: 1779-49-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:13:28

Product description	Number	Pack Size	Price
Methyltriphenylphosphonium bromide 98%	130079	25g	$34
Mettler-Toledo Calibration substance ME 30130598, Methyltriphenylphosphoniumbromide tracable to primary standards (LGC)	94993	5G	$91.5
Methyltriphenylphosphonium bromide 98%	130079	100g	$96.9
Methyltriphenylphosphonium Bromide >98.0%(HPLC)(T)	M0779	25g	$32
Methyltriphenylphosphonium Bromide >98.0%(HPLC)(T)	M0779	100g	$75
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Methyltriphenylphosphonium bromide Properties

Melting point	230-234 °C (lit.)
vapor pressure	0.0000002 hPa
Flash point	>240°C
storage temp.	Inert atmosphere,Room Temperature
solubility	H₂O: 0.1 g/mL, clear
form	Powder
color	White
PH	6.0-6.5 (400g/l, H2O, 20℃)
Water Solubility	400 g/L (25 ºC)
Sensitive	Hygroscopic
BRN	3599467
InChI	1S/C19H18P.BrH/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19;/h2-16H,1H3;1H/q+1;/p-1
InChIKey	LSEFCHWGJNHZNT-UHFFFAOYSA-M
SMILES	[Br-].C[P+](c1ccccc1)(c2ccccc2)c3ccccc3
LogP	-1.18
CAS DataBase Reference	1779-49-3(CAS DataBase Reference)
FDA UNII	LW2UZ3E9EG
NIST Chemistry Reference	Methyltriphenylphosphonium bromide(1779-49-3)
EPA Substance Registry System	Phosphonium, methyltriphenyl-, bromide (1779-49-3)
UNSPSC Code	12352101
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS09

Signal word

Danger

Hazard statements

H301-H411

Precautionary statements

P273-P301+P310+P330

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

20/21/22-36/37/38

Safety Statements

36/37-36-26

RIDADR

UN 1390 4.3/PG 2

WGK Germany

Autoignition Temperature

410 °C

TSCA

TSCA listed

HazardClass

6.1

PackingGroup

III

HS Code

29310095

Storage Class

6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Aquatic Chronic 2

Toxicity

LD50 orally in Rabbit: 118 mg/kg

NFPA 704

	1
2		1

Methyltriphenylphosphonium bromide price More Price(61)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	130079	Methyltriphenylphosphonium bromide 98%	1779-49-3	25g	$34	2025-07-31	Buy
Sigma-Aldrich	94993	Mettler-Toledo Calibration substance ME 30130598, Methyltriphenylphosphoniumbromide tracable to primary standards (LGC)	1779-49-3	5G	$91.5	2025-07-31	Buy
Sigma-Aldrich	130079	Methyltriphenylphosphonium bromide 98%	1779-49-3	100g	$96.9	2025-07-31	Buy
TCI Chemical	M0779	Methyltriphenylphosphonium Bromide >98.0%(HPLC)(T)	1779-49-3	25g	$32	2025-07-31	Buy
TCI Chemical	M0779	Methyltriphenylphosphonium Bromide >98.0%(HPLC)(T)	1779-49-3	100g	$75	2025-07-31	Buy

Product number	Packaging	Price	Buy
130079	25g	$34	Buy
94993	5G	$91.5	Buy
130079	100g	$96.9	Buy
M0779	25g	$32	Buy
M0779	100g	$75	Buy

Methyltriphenylphosphonium bromide Chemical Properties,Uses,Production

Chemical Properties

white powder

Uses

PTC catalyst

Uses

Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.

Uses

Methyltriphenylphosphonium bromide is used for methylenation through the Wittig reaction. It is utilized in the synthesis of an enyne and 9-isopropenyl -phenanthrene by using sodium amide as reagent. It is a lipophilic molecule and used to deliver molecules to specific cell components. Further, it acts as an antineoplastic agent.

General Description

Methyltriphenylphosphoniumbromide is an organophosphorus compound, with potential use as a precursor and a solvent in organic synthesis.

Mettler-Toledo calibration substance ME 30130598, methyltriphenylphosphoniumbromide is ideal for use in the regular calibration of Mettler-Toledo melting point instrument. Its value is a mean of 6 to 12 iterations with a Mettler-Toledo MP70 Excellence instrument that is calibrated against primary standards. The melting point is validated by Capillary method according to European Pharmacopeia (2.2.14.)

reaction suitability

reaction type: C-C Bond Formation

Synthesis

67-56-1

603-35-0

1779-49-3

Triphenylphosphine (10.0 g, 38 mmol) and methanol (20 mL) were used as raw materials, and 48% hydrobromic acid was added sequentially in a 100 mL round bottom flask. The reaction mixture was heated and refluxed at 110 °C for 8 h. The reaction process was monitored by thin layer chromatography (TLC). After completion of the reaction, the mixture was cooled to room temperature, dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure at 60 °C to give 13.3 g of white crystalline solid methyltriphenylphosphonium bromide in 99.2% yield.

Purification Methods

If the solid is sticky, wash it with *C6H6 and dry it in a vacuum over P2O5. [Marvel & Gall J Org Chem 24 1494 1959, Chem Ber 87 1318 1954, Milas & Priesing J Am Chem Soc 79 6295 1957, Wittig & Sch.llkopf Org Synth 40 66 1960.] The iodide, on recrystallisation from H2O, has m 187.5-188.5o [Mann et al. J Chem Soc 1130 1953, Wittig & Geissler Justus Liebigs Ann Chem 580 44 1953]. [Beilstein 16 IV 981.]

References

[1] Patent: CN107840792, 2018, A. Location in patent: Paragraph 0041; 0042
[2] Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 48, # 1-4, p. 279 - 280
[3] Synlett, 2014, vol. 25, # 1, p. 148 - 152

Methyltriphenylphosphonium bromide Preparation Products And Raw materials

Raw materials

Triphenylphosphine Methyl bromide Methanol

Preparation Products

4-Fluorostyrene 4-Chloro-alpha-methylstyrene alpha-cyclopropylstyrene Cyclohexene, 2-ethenyl-1,3,3-trimethyl- 9-Decenoic acid, methyl ester

4-VINYLBENZYL ACETATE 4-IODOSTYRENE Benzoic acid, 2-ethenyl- (9CI) 2-Hydroxystyrene 1-Piperidinecarboxylic acid, 3-Methylene-, phenylMethyl ester

Benzene, 1-ethenyl-2-(1-Methylethoxy)- P-TRIMETHYLSILYL STYRENE 4,4'-VINYLIDENEBIS(N,N-DIMETHYLANILINE) 3-VINYLBENZALDEHYDE 2-methylenepropane-1,3-diyl diacetate

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Methyltriphenylphosphonium bromide Suppliers

Global( 746)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shandong Promise New Material Co.,Ltd.	+86-18678104048 +86-15305334460	johnwang@promisechemical.com	China	88	58
Vinsce Bio pharm (Suzhou) Co Ltd	+undefined13962217456	info@vinsce.com	China	38	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5242	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615531151365	mina@chuanghaibio.com	China	18126	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20128	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13799	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21597	55

Supplier	Advantage
Shandong Promise New Material Co.,Ltd.	58
Vinsce Bio pharm (Suzhou) Co Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Hebei Chuanghai Biotechnology Co., Ltd	58
Henan Fengda Chemical Co., Ltd	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55

View Lastest Price from Methyltriphenylphosphonium bromide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-13	Methyltriphenylphosphonium bromide 1779-49-3	US $0.00 / KG	1KG	98%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-11	Methyltriphenylphosphonium bromide 1779-49-3	US $100.00-75.00 / kg	1kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-01-30	Methyltriphenylphosphonium bromide 1779-49-3	US $10.00 / KG	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd

Methyltriphenylphosphonium bromide
1779-49-3
US $0.00 / KG
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Methyltriphenylphosphonium bromide
1779-49-3
US $100.00-75.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

Methyltriphenylphosphonium bromide
1779-49-3
US $10.00 / KG
99%
Hebei Chuanghai Biotechnology Co., Ltd

Methyltriphenylphosphonium bromide Spectrum

Methyltriphenylphosphonium bromide(1779-49-3)MS Methyltriphenylphosphonium bromide(1779-49-3)¹HNMR Methyltriphenylphosphonium bromide(1779-49-3)¹³CNMR Methyltriphenylphosphonium bromide(1779-49-3)IR1 Methyltriphenylphosphonium bromide(1779-49-3)IR2 Methyltriphenylphosphonium bromide(1779-49-3)Raman

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