3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid
![3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Structure](CAS/GIF/196961-43-0.gif)
- CAS No.
- 196961-43-0
- Chemical Name:
- 3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid
- Synonyms
- CD 3254;CD3254,CD-3254;CD3254, 10 mM in DMSO;3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid;2-Propenoic acid, 3-[4-hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-
- CBNumber:
- CB72518841
- Molecular Formula:
- C24H28O3
- Molecular Weight:
- 364.48
- MDL Number:
- MFCD18086861
- MOL File:
- 196961-43-0.mol
| Product description | Number | Pack Size | Price |
| CD3254 ≥98% | 20870 | 1mg | $33 |
| CD3254 ≥98% | 20870 | 5mg | $123 |
| CD3254 ≥98% | 20870 | 10mg | $213 |
| CD3254 ≥97%(HPLC) | 3302 | 10 | $233 |
| CD3254 ≥97%(HPLC) | 3302 | 50 | $952 |
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Properties
| Melting point | 165 - 167°C |
|---|---|
| Boiling point | 508.0±50.0 °C(Predicted) |
| Density | 1.108±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.61±0.10(Predicted) |
| color | White to Off-White |
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20870 | CD3254 ≥98% | 196961-43-0 | 1mg | $33 | 2024-03-01 | Buy |
| Cayman Chemical | 20870 | CD3254 ≥98% | 196961-43-0 | 5mg | $123 | 2024-03-01 | Buy |
| Cayman Chemical | 20870 | CD3254 ≥98% | 196961-43-0 | 10mg | $213 | 2024-03-01 | Buy |
| Tocris | 3302 | CD3254 ≥97%(HPLC) | 196961-43-0 | 10 | $233 | 2021-12-16 | Buy |
| Tocris | 3302 | CD3254 ≥97%(HPLC) | 196961-43-0 | 50 | $952 | 2021-12-16 | Buy |
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Chemical Properties,Uses,Production
Description
CD3254 is a selective agonist of the retinoid X receptors (RXRs; EC50 = ~10 nM for human RXRβ) that is without effect on retinoic acid receptors (RARs). It stimulates the recruitment of the nuclear receptor interaction domain of the TRAP220 coactivator to RXRα/RARβ heterodimers in vitro. CD3254 also enhances the recruitment of the PPARγ coactivator 1α, PGC-1α, to RXRα/PPARγ heterodimers.
Uses
CD 3254 is a potent RXR agonist.
storage
Store at -20°C
References
[1] VIRGINIE NAHOUM. Modulators of the structural dynamics of the retinoid X receptor to reveal receptor function.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 44: 17323-17328. DOI: 10.1073/pnas.0705356104
[2] PETER W. JURUTKA. Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)[J]. Journal of Medicinal Chemistry, 2013, 56 21: 8432-8454. DOI: 10.1021/jm4008517
[3] VIVIAN POGENBERG. Characterization of the interaction between retinoic acid receptor/retinoid X receptor (RAR/RXR) heterodimers and transcriptional coactivators through structural and fluorescence anisotropy studies.[J]. The Journal of Biological Chemistry, 2005, 280 2: 1625-1633. DOI: 10.1074/jbc.m409302200
[4] ALBANE LE MAIRE. Activation of RXR-PPAR heterodimers by organotin environmental endocrine disruptors.[J]. EMBO Reports, 2009, 10 4: 367-373. DOI: 10.1038/embor.2009.8
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Preparation Products And Raw materials
Raw materials
Preparation Products
3-[4-Hydroxy-3-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)phenyl]-2-propenoicacid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32434 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39032 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 12952 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shandong Chengchuang Blue Sea Pharmaceutical Technology Co., Ltd. | 0531-58897130 15508676053 | drug_impurity@sdcclh.com | China | 3140 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11218 | 58 |
| Guangzhou Younan Technology Co., Ltd | 020-82000279 18988968278 | YN_research@163.com | China | 3003 | 58 |
