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ChemicalBook >> CAS DataBase List >>3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Structure
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide structure
CAS No.
412960-54-4
Chemical Name:
3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
Synonyms
Eeyarestatin 1;Eeyarestatin I;Eeyarestatin I - CAS 412960-54-4 - Calbiochem;Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1;3-(4-Chlorophenyl)-1-[3-(4-chlorophenyl)-5,5-dimethyl-1-[2-[2-[3-(5-nitro-2-furyl)allylidene]hydrazinyl]-2-oxoethyl]-2-oxoimidazolidin-4-yl]-1-hydroxyurea;3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea;3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide;1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide
CBNumber:
CB72518902
Molecular Formula:
C27H25Cl2N7O7
Molecular Weight:
630.44
MDL Number:
MFCD00319108
MOL File:
412960-54-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-04-24 14:59:17
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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Properties

Density 1.49±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL
form Light yellow-orange solid
pka 9.13±0.40(Predicted)
color Yellow to orange
biological source synthetic (organic)
InChIKey JTUXTPWYZXWOIB-UHFFFAOYSA-N
SMILES Clc1ccc(cc1)N2C(C(N(C2=O)CC(=O)NN=CC=Cc4[o]c(cc4)[N+](=O)[O-])(C)C)N(O)C(=O)Nc3ccc(cc3)Cl
UNSPSC Code 12352204
NACRES NA.77

SAFETY

Risk and Safety Statements

WGK Germany  3
Storage Class 11 - Combustible Solids

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide price More Price(31)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich E1286 Eeyarestatin I ≥98% (HPLC) 412960-54-4 10mg $357 2026-04-30 Buy
Sigma-Aldrich 324521 Eeyarestatin I 412960-54-4 25mg $291 2026-04-30 Buy
Cayman Chemical 10012609 Eeyarestatin 1 ≥98% 412960-54-4 5mg $62 2026-04-30 Buy
Cayman Chemical 10012609 Eeyarestatin 1 ≥98% 412960-54-4 10mg $116 2026-04-30 Buy
Cayman Chemical 10012609 Eeyarestatin 1 ≥98% 412960-54-4 25mg $222 2026-04-30 Buy
Product number Packaging Price Buy
E1286 10mg $357 Buy
324521 25mg $291 Buy
10012609 5mg $62 Buy
10012609 10mg $116 Buy
10012609 25mg $222 Buy

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Chemical Properties, Uses, Production

Uses

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation.

Biochem/physiol Actions

Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD). Specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Also inhibits Sec61-mediated protein translocation at the ER. Displays cytotoxic activity preferentially against cancer cells; induces cell death via the proapoptotic protein NOXA.

storage

Store at +4°C

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Suppliers

Global Suppliers ( 64)
Supplier Tel Email Country ProdList Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8435 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9799 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Career Henan Chemica Co +86-0371-86658258 +86-13203830695 laboratory@coreychem.com China 30203 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912 order@med-bio.cn China 8137 58
Supplier Advantage
3B Pharmachem (Wuhan) International Co.,Ltd. 69
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Sigma-Aldrich 80
EMMX Biotechnology LLC 60
Shanghai EFE Biological Technology Co., Ltd. 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
MedBioPharmaceutical Technology Inc 58

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Spectrum

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide(412960-54-4)1HNMR

412960-54-4 (3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide) Related Search:

3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide 6-fluoro-N-(4-fluorobenzyl)quinazolin-4-aMine VLX1570 N1-(4-Butyl-2-methylphenyl)acetamide CB5083
Hsp27 (human recombinant)

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3-(4-Chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-1-imidazolidineaceticacid2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide Eeyarestatin I Eeyarestatin 1 Eeyarestatin I - ES1 | ERAD inhibitor 1 | p97 inhibitor 1 Eeyarestatin I - CAS 412960-54-4 - Calbiochem 1-Imidazolidineacetic acid, 3-(4-chlorophenyl)-4-[[[(4-chlorophenyl)amino]carbonyl]hydroxyamino]-5,5-dimethyl-2-oxo-, 2-[3-(5-nitro-2-furanyl)-2-propen-1-ylidene]hydrazide 3-(4-Chlorophenyl)-1-(3-(4-chlorophenyl)-5,5-dimethyl-1-(2-(2-(3-(5-nitrofuran-2-yl)allylidene)hydrazineyl)-2-oxoethyl)-2-oxoimidazolidin-4-yl)-1-hydroxyurea 3-(4-Chlorophenyl)-1-[3-(4-chlorophenyl)-5,5-dimethyl-1-[2-[2-[3-(5-nitro-2-furyl)allylidene]hydrazinyl]-2-oxoethyl]-2-oxoimidazolidin-4-yl]-1-hydroxyurea 412960-54-4 C27H25Cl2N7O7