Fmoc-Asp(OAll)-OH
- CAS No.
- 146982-24-3
- Chemical Name:
- Fmoc-Asp(OAll)-OH
- Synonyms
- FMoc-Asp;FMOC-L-ASPARTIC ACID 4-ALLYL ESTER;FMOC-ASP(OALLYL)-OH;CAS:146982-24-3;FMOC-ASP(OAL)-OH;FMOC-ASP(OAI)-OH;Fmoc-Asp(0all)-OH;Fmoc-Asp(OAll)-OH;FMOC-L-ASP(OAL)-OH;FMOC-L-ASP(ALL)-OH
- CBNumber:
- CB7253179
- Molecular Formula:
- C22H21NO6
- Molecular Weight:
- 395.41
- MDL Number:
- MFCD00190874
- MOL File:
- 146982-24-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 111-115 °C |
|---|---|
| Boiling point | 638.5±55.0 °C(Predicted) |
| Density | 1.286±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | Soluble in water or 1% acetic acid |
| form | Solid |
| pka | 3.59±0.23(Predicted) |
| color | White to off-white |
| optical activity | [α]20/D 27±2°, c = 1% in DMF |
| Water Solubility | Slightly soluble in water. |
| BRN | 6670219 |
| Major Application | peptide synthesis |
| InChI | 1S/C22H21NO6/c1-2-11-28-20(24)12-19(21(25)26)23-22(27)29-13-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h2-10,18-19H,1,11-13H2,(H,23,27)(H,25,26)/t19-/m0/s1 |
| InChIKey | FBNFRRNBFASDKS-IBGZPJMESA-N |
| SMILES | OC(=O)[C@H](CC(=O)OCC=C)NC(=O)OCC1c2ccccc2-c3ccccc13 |
| CAS DataBase Reference | 146982-24-3(CAS DataBase Reference) |
| UNSPSC Code | 12352209 |
| NACRES | NA.26 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H200-H302-H335-H312 | |||||||||
| Precautionary statements | P201-P202-P281-P372-P373-P380-P401-P501-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2924 29 70 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Fmoc-Asp(OAll)-OH price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 8.52122 | Fmoc-Asp(OAll)-OH Novabiochem? | 146982-24-3 | 5G | $137 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.52122 | Fmoc-Asp(OAll)-OH Novabiochem? | 146982-24-3 | 25g | $529 | 2026-04-30 | Buy |
| Sigma-Aldrich | 47579 | Fmoc-Asp(OAll)-OH ≥98.0% (HPLC) | 146982-24-3 | 1g | $65 | 2026-04-30 | Buy |
| Usbiological | 277002 | Fmoc-L-aspartic acid beta-allyl ester Asreported | 146982-24-3 | 5g | $363 | 2026-06-03 | Buy |
| Usbiological | 277002 | Fmoc-L-aspartic acid beta-allyl ester Asreported | 146982-24-3 | 10g | $503 | 2026-06-03 | Buy |
Fmoc-Asp(OAll)-OH Chemical Properties, Uses, Production
Preparation
1. In a three-necked flask, tetrahydrofuran and aspartic acid were mixed, and phosphorus oxychloride was added dropwise at low temperature. After reacting for 6 hours, the mixture was filtered to obtain a solid intermediate. 2. The solid intermediate was washed with anhydrous diethyl ether, dried, and then reacted with allyl alcohol, controlling the temperature and time. After the reaction, the pH was adjusted to 7 with triethylamine to precipitate the solid. 3. The solid was washed with diethyl ether and dried to obtain intermediate L-Asp-0A11. 4. L-Asp-0A11 was dissolved in sodium bicarbonate solution, and acetone and Fmoc-0Su were added. The pH was controlled at around 9, and the reaction was carried out at low temperature for 3 hours. 5. After the reaction, the product was washed with anhydrous diethyl ether, extracted with ethyl acetate, and concentrated to dryness after acidification, washing, and drying. 6. Finally, the target product, FMOC-ASP(OALL)-OH, was obtained by crystallization with petroleum ether.
Chemical Properties
White crystalline powder
Uses
Fmoc-Asp(OAll)-OH, is an amino acid building block used in peptide synthesis. With a growing peptide drug market the fast, reliable synthesis of peptides is of great importance.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Fmoc-Asp(OAll)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| GL Biochem (Shanghai) Ltd | 21-61263452 13641803416 | ymbetter@glbiochem.com | China | 9981 | 64 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
View Latest Price from Fmoc-Asp(OAll)-OH manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | FMOC-ASP(OALL)-OH
146982-24-3
|
$1.00 | 1KG | 99% | 20kg | Career Henan Chemical Co | |
 |
2019-07-06 | FMOC-ASP(OALL)-OH
146982-24-3
|
$7.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- FMOC-ASP(OALL)-OH
146982-24-3
- $1.00
- 99%
- Career Henan Chemical Co
-
- FMOC-ASP(OALL)-OH
146982-24-3
- $7.00
- 99%
- Career Henan Chemical Co
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