5-amino-2-bromo-4-methylbenzoic acid
- CAS No.
- 745048-63-9
- Chemical Name:
- 5-amino-2-bromo-4-methylbenzoic acid
- Synonyms
- 3-Amino-6-bromo-4-methylbenzoic acid;5-amino-2-bromo-4-methylbenzoic acid;Benzoic acid, 5-amino-2-bromo-4-methyl-
- CBNumber:
- CB72535619
- Molecular Formula:
- C8H8BrNO2
- Molecular Weight:
- 230.06
- MDL Number:
- MFCD14706184
- MOL File:
- 745048-63-9.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-Amino-2-bromo-4-methylbenzoicAcid | A576963 | 25mg | $45 |
| 5-AMINO-2-BROMO-4-METHYLBENZOIC ACID 95.00% | HCH0366663 | 5MG | $495.66 |
| 5-Amino-2-bromo-4-methylbenzoicacid | 1570AC | 100mg | $138 |
| 5-Amino-2-bromo-4-methylbenzoicacid 95+% | A192324 | 5g | $215 |
| 5-Amino-2-bromo-4-methyl-benzoic acid 95+% | SC-25746 | 5G | $245 |
| More product size | |||
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
5-amino-2-bromo-4-methylbenzoic acid price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A576963 | 5-Amino-2-bromo-4-methylbenzoicAcid | 745048-63-9 | 25mg | $45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | HCH0366663 | 5-AMINO-2-BROMO-4-METHYLBENZOIC ACID 95.00% | 745048-63-9 | 5MG | $495.66 | 2021-12-16 | Buy |
| AK Scientific | 1570AC | 5-Amino-2-bromo-4-methylbenzoicacid | 745048-63-9 | 100mg | $138 | 2021-12-16 | Buy |
| Ambeed | A192324 | 5-Amino-2-bromo-4-methylbenzoicacid 95+% | 745048-63-9 | 5g | $215 | 2021-12-16 | Buy |
| SynChem | SC-25746 | 5-Amino-2-bromo-4-methyl-benzoic acid 95+% | 745048-63-9 | 5G | $245 | 2021-12-16 | Buy |
5-amino-2-bromo-4-methylbenzoic acid Chemical Properties,Uses,Production
Synthesis
2458-12-0
745048-63-9
The general procedure for the synthesis of 5-amino-2-bromo-4-methylbenzoic acid from 3-amino-4-methylbenzoic acid was as follows: 3-amino-4-methylbenzoic acid (24.72 g, 162 mmol) was dissolved in anhydrous DMF (140 mL). Subsequently, the solution was cooled to 0-5 °C and N-bromosuccinimide (29.70 g, 163.5 mmol) was added in batches while keeping the temperature of the reaction mixture below 15 °C. The reaction mixture was stirred under these conditions for 2 hours. Upon completion of the reaction, the mixture was slowly poured into an ice-water mixture (150 g) while stirring was continued. The precipitated solid was collected by filtration and washed with cold water (3 x 120 mL). The resulting filter cake was dissolved in EtOAc (800 mL) and the organic layer was washed with water (3 x 200 mL). The organic layer was subsequently dried with anhydrous magnesium sulfate, filtered and the solvent was removed by vacuum evaporation to afford 5-amino-2-bromo-4-methylbenzoic acid as a pink solid (31.59 g, 85% yield).
References
[1] European Journal of Medicinal Chemistry, 2011, vol. 46, # 7, p. 2662 - 2675
[2] Patent: WO2011/159067, 2011, A2. Location in patent: Page/Page column 28
[3] Patent: US2007/275907, 2007, A1. Location in patent: Page/Page column 19
[4] Patent: US2008/242596, 2008, A1. Location in patent: Page/Page column 15
[5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 19, p. 5632 - 5635
5-amino-2-bromo-4-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14360 | 58 |
| CR Corporation Limited | +8613062833949 | fred.wen@crcorporation.cn | China | 8647 | 58 |
| Changzhou Helios Biomedical Science and Technology Co.,LTD. | +8618961213068 | gaoxue@czhelios.com | China | 512 | 58 |
| Changzhou Anxuan Chemical Co., Ltd | +86-0519-89882563 +86-18961279162 | andy@anxuanchem.com | China | 4327 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418684 +8618949823763 | sales@tnjchem.com | China | 25356 | 58 |
| Aromsyn Co., Ltd. | +86-0571-85585865 +8613336024896 | CB@aromsyn.com | China | 19183 | 58 |
| Aceschem Inc. | +1-817863-6948 +1-（817）863-6948 | sales@aceschem.com | United States | 19632 | 58 |
