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ChemicalBook >> CAS DataBase List >>[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Structure
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone structure
CAS No.
1000669-72-6
Chemical Name:
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
Synonyms
CS-468;KW 2449;KW-2449 100MG;KW2449;KW 2449;KW-2449 ，S2158;KW-2449, 10 mM in DMSO;KW-2449;KW 2449; KW2449;KW-2449 hydrochloride HCL;[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone
CBNumber:
CB72554360
Molecular Formula:
C20H20N4O
Molecular Weight:
332.4
MDL Number:
MFCD18385006
MOL File:
1000669-72-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Properties

Boiling point 604.1±55.0 °C(Predicted)
Density 1.28
storage temp. -20°C
solubility Soluble in DMSO (>25 mg/ml)
pka 13.76±0.40(Predicted)
form solid
color Pale yellow
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
FDA UNII 2D9N67F58G

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 5mg $36 2026-04-30 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 10mg $64 2026-04-30 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 25mg $150 2026-04-30 Buy
Cayman Chemical 22207 KW 2449 ≥98% 1000669-72-6 50mg $264 2026-04-30 Buy
Biosynth FI153964 [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone 1000669-72-6 5mg $900 2026-06-04 Buy
Product number Packaging Price Buy
22207 5mg $36 Buy
22207 10mg $64 Buy
22207 25mg $150 Buy
22207 50mg $264 Buy
FI153964 5mg $900 Buy

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties, Uses, Production

Description

KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3

Uses

KW-2449 is a multi-targeted kinase inhibitor of FLT3, ABL, ABLT315I and Aurora kinase with IC50s of 6.6, 14, 4 and 48 nM, respectively.

Definition

ChEBI: [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-(1-piperazinyl)methanone is a member of indazoles.

in vivo

Oral administration of KW-2449 shows dose-dependent and significant tumor growth inhibition in FLT3-mutated xenograft model with minimum bone marrow suppression. In FLT3 wild-type human leukemia, it induces the reduction of phosphorylated histone H3, G2/M arrest, and apoptosis. In imatinib-resistant leukemia, KW-2449 contributes to release of the resistance by the simultaneous down-regulation of BCR/ABL and Aurora kinases. Furthermore, the antiproliferative activity of KW-2449 is confirmed in primary samples from AML and imatinib-resistant patients. The inhibitory activity of KW-2449 is not affected by the presence of human plasma protein, such as α1-acid glycoprotein[1].

target

FLT3

IC 50

Abl: 4 nM (IC50); ABL-T315I: 14 nM (IC50); FGFR1: 36 nM (IC50); Aurora A: 48 nM (IC50); FLT3/D835Y: 1 nM (IC50); FLT3: 6.6 nM (IC50); JAK2: 150 nM (IC50); SRC: 400 nM (IC50); PDFGRα: 1700 nM (IC50)

References

[1] Y. SHIOTSU. KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1 and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo .[J]. Blood, 2007, 110 1: 1832-1832. DOI:10.1182/blood.v110.11.1832.1832
[2] KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation
[3] KEITH W PRATZ. A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response.[J]. Blood, 2009, 113 17: 3938-3946. DOI:10.1182/blood-2008-09-177030

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials

Raw materials

Preparation Products

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Suppliers

Global Suppliers ( 137)
Supplier Tel Email Country ProdList Advantage
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652 sales@meilune.com China 4765 58
Shanghai civi chemical technology co.,Ltd 86-21-34053660 sale@labgogo.com China 9853 52
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 China 1490 55
Haoyuan Chemexpress Co., Ltd. 021-58950125 info@chemexpress.com China 7545 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-6206333 13167063860 anhua.mao@aladdin-e.com China 29977 65
Nanjing Dulai Biotechnology Co., Ltd. 025-84699383-8003;025-846993838003-8003 18013301590 njduly@126.com China 3293 55
Nanjing Sunlida Biological Technology Co., Ltd. 025-57798810 18652991625 sales@sunlidabio.com China 3223 55
Supplier Advantage
Chembest Research Laboratories Limited 61
Jinan Trio PharmaTech Co., Ltd. 62
Dalian Meilun Biotech Co., Ltd. 58
Shanghai civi chemical technology co.,Ltd 52
Shanghai Topbiochem Technology Co., Ltd 58
NCE Biomedical Co.,Ltd. 55
Haoyuan Chemexpress Co., Ltd. 61
Shanghai Aladdin Bio-Chem Technology Co.,LTD 65
Nanjing Dulai Biotechnology Co., Ltd. 55
Nanjing Sunlida Biological Technology Co., Ltd. 55

View Latest Price from [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
KW-2449 pictures 2026-07-27 KW-2449
1000669-72-6
 $48.00-196.00 99.89% 10g TargetMol Chemicals Inc.
[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone pictures 2019-07-06 [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone
1000669-72-6
 $1950.00-2000.00 1KG 98% 100kg Career Henan Chemical Co
  • KW-2449 pictures
  • KW-2449
    1000669-72-6
  • $48.00-196.00
  • 99.89%
  • TargetMol Chemicals Inc.

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Spectrum

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone(1000669-72-6)1HNMR

1000669-72-6 ([4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone) Related Search:

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1of3

[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone KW 2449 (E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride KW-2449;KW 2449; KW2449 [4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone KW-2449 100MG {4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone 3-[(E)-2-{4-[(PIPERAZIN-1-YL)CARBONYL]PHENYL}ETHENYL]-2H-INDAZOLE KW2449;KW 2449 CS-468 Methanone, [4-[2-(1H-indazol-3-yl)ethenyl]phenyl]-1-piperazinyl- [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone USP/EP/BP KW-2449 hydrochloride HCL (4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone KW-2449, 10 mM in DMSO KW-2449 ，S2158 1000669-72-6 Inhibitors Inhibitor