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CAY10416

CAY10416 Structure
CAY10416 structure
CAS No.
443919-96-8
Chemical Name:
CAY10416
Synonyms
CAY10416;COX-25-LOX-IN-4;CAY10416,CAY-10416;3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole;1H-Pyrazole, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-
CBNumber:
CB72590410
Molecular Formula:
C29H29FN2O5S
Molecular Weight:
536.61
MDL Number:
MFCD12912357
MOL File:
443919-96-8.mol
MSDS File:
SDS
Last updated:2026-05-11 19:39:08
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CAY10416 Properties

storage temp. Store at -20°C
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml
form A crystalline solid

CAY10416 price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 70635 CAY10416 ≥95% 443919-96-8 1mg $63 2026-04-30 Buy
Cayman Chemical 70635 CAY10416 ≥95% 443919-96-8 5mg $274 2026-04-30 Buy
Cayman Chemical 70635 CAY10416 ≥95% 443919-96-8 10mg $481 2026-04-30 Buy
ChemScene CS-0066475 COX-2/5-LOX-IN-4 443919-96-8 1mg $217 2026-06-04 Buy
ChemScene CS-0066475 COX-2/5-LOX-IN-4 443919-96-8 5mg $651 2026-06-04 Buy
Product number Packaging Price Buy
70635 1mg $63 Buy
70635 5mg $274 Buy
70635 10mg $481 Buy
CS-0066475 1mg $217 Buy
CS-0066475 5mg $651 Buy

CAY10416 Chemical Properties, Uses, Production

Description

Dual cyclooxygenase-2 (COX-2)/5-lipoxygenase (5-LO) inhibitors are potential therapeutic agents for inflammatory diseases and for prostate cancer. CAY10416 is a dual COX-2/5-LO inhibitor with IC50 values of 50 and 3 nM, respectively. The selectivity of CAY10416 for COX is greater than 200-fold for COX-2 versus COX-1. COX-2/5-LO inhibitors such as CAY10416 are also apoptosis-inducing agents and are potentially useful in prostate cancer chemotherapy. In the PC3 human carcinoma cell line, CAY10416 exhibits a 45% inhibition of proliferation at 100 μM. In the LNCaP human carcinoma cell line, CAY10416 inhibits growth with an IC50 value of 83 μM.

Uses

3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole is a dual inhibitor of Cox-2 and 5-LO.

References

[1] SABINE BARBEY . Synthesis and Activity of a New Methoxytetrahydropyran Derivative as Dual Cyclooxygenase-2/5-Lipoxygenase Inhibitor[J]. Bioorganic & Medicinal Chemistry Letters, 2002, 12 5: Pages 779-782. DOI: 10.1016/s0960-894x(02)00013-6

CAY10416 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10416 Suppliers

Global Suppliers ( 28)
Supplier Tel Email Country ProdList Advantage
Shanghai Beckham Medical Technology Co., Ltd 13816613772 huahero21@sina.com China 2994 55
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 400-920-5774 sales@glpbio.cn China 6705 58
BOC Sciences 16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44871 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7982 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
Shanghai Beckham Medical Technology Co., Ltd 55
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from CAY10416 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
CAY10416 pictures 2026-05-11 CAY10416
443919-96-8
 $198.00-1580.00 10g TargetMol Chemicals Inc.
  • CAY10416 pictures
  • CAY10416
    443919-96-8
  • $198.00-1580.00
  • TargetMol Chemicals Inc.

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CAY10416 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl-1H-pyrazole 1H-Pyrazole, 3-[[3-fluoro-5-(tetrahydro-4-methoxy-2H-pyran-4-yl)phenoxy]methyl]-1-[4-(methylsulfonyl)phenyl]-5-phenyl- CAY10416,CAY-10416 COX-25-LOX-IN-4 443919-96-8 C29H29FN2O5S