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Phthalazinone pyrazole

Phthalazinone pyrazole Structure
Phthalazinone pyrazole structure
CAS No.
880487-62-7
Chemical Name:
Phthalazinone pyrazole
Synonyms
Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-((5-Methyl-1H-pyrazol-3-yl)amino)-2-phenylphthalazin-1(2H)-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
CBNumber:
CB72592005
Molecular Formula:
C18H15N5O
Molecular Weight:
317.34
MDL Number:
MFCD28399120
MOL File:
880487-62-7.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-27 17:00:41
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Phthalazinone pyrazole Properties

Boiling point 557.7±52.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
form crystalline solid
pka 13.83±0.10(Predicted)
color Brown to gray

Phthalazinone pyrazole price More Price(32)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 10735 Phthalazinone pyrazole ≥98% 880487-62-7 1mg $75 2026-04-30 Buy
Cayman Chemical 10735 Phthalazinone pyrazole ≥98% 880487-62-7 5mg $333 2026-04-30 Buy
Cayman Chemical 10735 Phthalazinone pyrazole ≥98% 880487-62-7 10mg $589 2026-04-30 Buy
ChemScene CS-0012034 Phthalazinone pyrazole 98.0% 880487-62-7 5mg $56 2026-06-04 Buy
ChemScene CS-0012034 Phthalazinone pyrazole 98.0% 880487-62-7 10mg $91 2026-06-04 Buy
Product number Packaging Price Buy
10735 1mg $75 Buy
10735 5mg $333 Buy
10735 10mg $589 Buy
CS-0012034 5mg $56 Buy
CS-0012034 10mg $91 Buy

Phthalazinone pyrazole Chemical Properties,Uses,Production

Description

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

Uses

Phthalazinone pyrazole is a potent, selective, and orally active inhibitor of Aurora-A kinase with an IC50 of 0.031 μM. Phthalazinone pyrazole can arrests mitosis and subsequently inhibit tumor growth via apoptosis of proliferating cells. Phthalazinone pyrazole suppresses the epithelial-mesenchymal transition (EMT) during the differentiation of hepatocyte-like cells (HLCs) from human embryonic stem cells[1][2].

in vitro

phthalazinone pyrazole potently inhibited the activity of aurora a kinase with an ic50 of 31 nm. it showed no inhibitory effect on aurora b kinase at doses up to 100 μm. phthalazinone pyrazole inhibited the proliferation of hct116, colo205, and mcf-7 cells with ic50 values of 7.8, 2.9, and 1.6 μm, respectively [1].

IC 50

Aurora-A: 0.031 μM (IC50)

References

[1] prime m e, courtney s m, brookfield f a, et al. phthalazinone pyrazoles as potent, selective, and orally bioavailable inhibitors of aurora-a kinase[j]. journal of medicinal chemistry, 2010, 54(1): 312-319.
[2] vader g, lens s m a. the aurora kinase family in cell division and cancer[j]. biochimica et biophysica acta (bba)-reviews on cancer, 2008, 1786(1): 60-72.

Phthalazinone pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

Phthalazinone pyrazole Suppliers

Global( 49)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4861 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Shanghai Rechem science Co., Ltd. 021-31433387 15618786686 sales@rechemscience.com China 2970 58
Shanghai Chaolan Chemical Technology Center QQ：65489617 13301690235 Sales@ATKchemical.com China 9699 58
Shanghai Yu Ben Biotechnology Co., Ltd. 021-61350663 15502154572 1639466865@qq.com China 499 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Changzhou Chenhong Biotechnology Co., Ltd. +86-0519-85788828 +86-13775037613 sales@chemrenpharm.com China 4058 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Supplier Advantage
BOC Sciences 65
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Shanghai Rechem science Co., Ltd. 58
Shanghai Chaolan Chemical Technology Center 58
Shanghai Yu Ben Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Changzhou Chenhong Biotechnology Co., Ltd. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58

View Lastest Price from Phthalazinone pyrazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Phthalazinone pyrazole pictures 2026-07-27 Phthalazinone pyrazole
880487-62-7
 $41.00-137.00 98.22% 10g TargetMol Chemicals Inc.

Phthalazinone pyrazole Spectrum

Phthalazinone pyrazole(880487-62-7)1HNMR

880487-62-7(Phthalazinone pyrazole)Related Search:

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