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ChemicalBook >> CAS DataBase List >>2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Structure
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- structure
CAS No.
865305-30-2
Chemical Name:
2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
Synonyms
Ro 4;AF 353;CS-2469;CHEMBL526307;AF-353 (Ro-4);AF-353, 10 mM in DMSO;CHEMBL526307;AF 353;AF353;5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine;Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine
CBNumber:
CB72609596
Molecular Formula:
C14H17IN4O2
Molecular Weight:
400.21
MDL Number:
MFCD18782750
MOL File:
865305-30-2.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
Product description Number Pack Size Price
AF-353 23034 1mg $32
AF-353 23034 5mg $102
AF-353 99.43% CS-5061 5mg $61
AF 353 BA165790 1mg $250
AF-353 99.43% CS-5061 10mg $97
More product size
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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Properties

Boiling point 510.2±60.0 °C(Predicted)
Density 1.619±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : ≥ 32 mg/mL (79.96 mM)
pka 6.89±0.10(Predicted)
form Solid
color Light brown to brown
InChI InChI=1S/C14H17IN4O2/c1-7(2)8-4-11(20-3)9(15)5-10(8)21-12-6-18-14(17)19-13(12)16/h4-7H,1-3H3,(H4,16,17,18,19)
InChIKey AATPYXMXFBBKFO-UHFFFAOYSA-N
SMILES C1(N)=NC=C(OC2=CC(I)=C(OC)C=C2C(C)C)C(N)=N1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 23034 AF-353 865305-30-2 1mg $32 2022-04-27 Buy
Cayman Chemical 23034 AF-353 865305-30-2 5mg $102 2022-04-27 Buy
ChemScene CS-5061 AF-353 99.43% 865305-30-2 5mg $61 2026-06-04 Buy
Biosynth BA165790 AF 353 865305-30-2 1mg $250 2026-06-04 Buy
ChemScene CS-5061 AF-353 99.43% 865305-30-2 10mg $97 2026-06-04 Buy
Product number Packaging Price Buy
23034 1mg $32 Buy
23034 5mg $102 Buy
CS-5061 5mg $61 Buy
BA165790 1mg $250 Buy
CS-5061 10mg $97 Buy

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Chemical Properties,Uses,Production

Description

AF-353 is a noncompetitive dual antagonist of the purinoreceptors P2X3 and P2X2/3 (IC50s = 10 and 79.4 nM, respectively). It is selective for P2X3 and P2X2/3 over P2X1, P2X2, P2X4, P2X5, and P2X7 (IC50 = >10 μM for all). It inhibits calcium flux in CHO-K1 cells expressing the rat P2X3 receptor and in 1321N1 cells expressing the human P2X3 and P2X2/3 receptors (IC50s = 8.91, 8.71, and 38.9 nM, respectively). AF-353 decreases the electrical signals in the detrusor, but not striated, muscle of the bladder in female rats.

Uses

AF-353 (Ro-4) is a potent, selective and orally bioavailable P2X3/P2X2/3 receptor antagonist, with a pIC50 of 8.0 for both human and rat P2X3, and with a pIC50 of 7.3 for human P2X2/3[1][2].

in vivo

AF-353 (Ro-4) does not compromise oxygen levels or cardiac function[2].
AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) inhibits the purinergic response in both normal and spinal cord-injured (SCI) rats[2].
AF-353 (Ro-4) (10 mg/kg, 20 mg/kg; i.v.; for 4-6 hours) also reduces the inter-contractile interval in normal but not in SCI rats; however, the frequency of non-voiding (NVC) in SCI rats is significantly reduced[2].

Animal Model:Female Sprague-Dawley rats (250–300 g) bearing SCI[2]
Dosage:10 mg/kg, 20 mg/kg
Administration:Intravenous injection; interval of 90 minutes, for 4 hours to 6 hours
Result:Significantly reduced purinergic response in both normal and SCI rats.

IC 50

P2X3 Receptor

References

[1] Gever JR, et al. AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist. Br J Pharmacol. 2010 Jul;160(6):1387-1398. DOI:10.1111/j.1476-5381.2010.00796.x
[2] Munoz A, et al. Modulation of bladder afferent signals in normal and spinal cord-injured rats by purinergic P2X3 and P2X2/3receptors. BJU Int. 2012 Oct;110(8 Pt B):E409-414. DOI:10.1111/j.1464-410X.2012.11189.x

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Suppliers

Global( 84)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
BOC Sciences 		16314854226; +8616314854226 inquiry@bocsci.com United States 19852 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +86-15965530500 nickzhang@hangyubiotech.com China 9935 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 +86-15355479329 market18@leapchem.com China 43303 58
Aladdin Scientific 		tp@aladdinsci.com United States 54746 58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		+86-13382787392 sales@aeechem.com China 10000 58
Amadis Chemical Company Limited 		571-89925085 sales@amadischem.com China 131885 58
Shanghai Jinyin Biological Technology Co., Ltd 021-20986266 18019349802 814527417@qq.com China 461 58
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4857 55
Supplier Advantage
TargetMol Chemicals Inc. 		58
BOC Sciences 		58
Zibo Hangyu Biotechnology Development Co., Ltd 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
NANJING YINGWEN BIOTECHNOLOGY CO LTD 		58
Amadis Chemical Company Limited 		58
Shanghai Jinyin Biological Technology Co., Ltd 58
Chembest Research Laboratories Limited 61
Shanghai Lollane Biological Technology Co.,Ltd. 55

View Lastest Price from 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
AF-353 pictures 2026-07-14 AF-353
865305-30-2
 $42.00-153.00 99.35% 10g TargetMol Chemicals Inc.
af-353 pictures 2022-02-25 af-353
865305-30-2
 $100.00 1KG 98% 100KG Hong Kong Tiansheng New Material Trading Co., Ltd
af-353 pictures 2022-02-25 af-353
865305-30-2
 $100.00 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd
  • AF-353 pictures
  • AF-353
    865305-30-2
  • $42.00-153.00
  • 99.35%
  • TargetMol Chemicals Inc.
  • af-353 pictures
  • af-353
    865305-30-2
  • $100.00
  • 98%
  • Hong Kong Tiansheng New Material Trading Co., Ltd
  • af-353 pictures
  • af-353
    865305-30-2
  • $100.00
  • 99%
  • Hong Kong Tiansheng New Material Trading Co., Ltd

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- Spectrum

2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(865305-30-2)1HNMR

865305-30-2(2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-)Related Search:

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2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]- AF 353 Ro 4 5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine CHEMBL526307 CHEMBL526307;AF 353;AF353 CS-2469 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine hydrochloride Ro 4 hydrochloride 5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine AF-353 (Ro-4) 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine Ro4,inhibit,AF-353,P2X Receptor,Inhibitor,Ro 4,P2XRs,AF353,AF 353 AF-353, 10 mM in DMSO 865305-30-2 C14H17IN4O2 Inhibitors