MBX2982
- CAS No.
- 1037792-44-1
- Chemical Name:
- MBX2982
- Synonyms
- CS-485;MBX2982;SAR-260093;MBX-2982, >=98%;MBX2982 / MBX-2982;MBX-2982 (SAR260093);MBX-2982, 10 mM in DMSO;MBX-2982;MBX 2982;MBX2982;2-[1-(5-ethylpyrimidin-2-yl)-4-piperidyl]-4-[[4-(tetrazol-1-yl)phenoxy]methyl]thiazole;4-((4-(1H-Tetrazol-1-yl)phenoxy)methyl)-2-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)thiazole
- CBNumber:
- CB72620009
- Molecular Formula:
- C22H24N8OS
- Molecular Weight:
- 448.54
- MDL Number:
- MFCD22628771
- MOL File:
- 1037792-44-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 683.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.42 |
| storage temp. | Store at -20°C |
| solubility | DMSO : 50 mg/mL (111.47 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 5.39±0.42(Predicted) |
| color | White to off-white |
| FDA UNII | B5TRY67L51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501 | |||||||||
| NFPA 704 |
|
MBX2982 price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22206 | MBX-2982 ≥98% | 1037792-44-1 | 5mg | $169 | 2026-04-30 | Buy |
| Cayman Chemical | 22206 | MBX-2982 ≥98% | 1037792-44-1 | 10mg | $303 | 2026-04-30 | Buy |
| Cayman Chemical | 22206 | MBX-2982 ≥98% | 1037792-44-1 | 25mg | $667 | 2026-04-30 | Buy |
| Cayman Chemical | 22206 | MBX-2982 ≥98% | 1037792-44-1 | 50mg | $929 | 2026-04-30 | Buy |
| Biosynth | FE58289 | 5-Ethyl-2-[4-[4-[[[4-(1H-tetrazol-1-yl)phenyl]oxy]methyl]thiazol-2-yl]piperidin-1-yl]pyrimidine | 1037792-44-1 | 5mg | $226.85 | 2026-06-04 | Buy |
MBX2982 Chemical Properties, Uses, Production
Description
MBX-2982 is an agonist of GPR119. It reduces nuclear and total protein levels of sterol regulatory element binding protein 1 (SREBP-1) in HepG2 cells and rat primary hepatocytes under high-glucose and -insulin conditions and increases phosphorylation of the inhibitory form, SREBP-1c. MBX-2982 (10 mg/kg) inhibits hepatic lipid accumulation in wild-type, but not GPR119 knockout, mice fed a high-fat diet. It also increases plasma levels of glucagon-like peptide 1 (GLP-1; ) in mice when administered at a dose of 10 mg/kg prior to, and to a greater extent following, glucose administration. MBX-2982 increases glucokinase activity in an enzyme assay with an EC50 value of 45.11 μM.
Uses
MBX-2982 is a selective, orally-available G protein-coupled receptor 119 (GPR119) agonist.
in vivo
To examine whether the observations in GLUTag and the primary intestinal cells has physiological relevance, C57BL/6 mice are treated with the GPR119 agonist MBX-2982 at a dose of 10 mg/kg. Note that in order to examine a direct GPR119 effect, no DPP-IV inhibitor is co-administered in this experiment, but a DPP-IV inhibitor is used to preserve active GLP-1 in the blood samples. The plasma GLP-1 levels from the mice dosed with MBX-2982 are increased without a glucose load, indicating that GPR119-mediated GLP-1 secretion is not dependent on glucose[2].
References
[1] Hothersall JD, et al. Sustained wash-resistant receptor activation responses of GPR119 agonists. Eur J Pharmacol. 2015 Sep 5;762:430-42. DOI:10.1016/j.ejphar.2015.06.031
[2] Lan H, et al. Agonists at GPR119 mediate secretion of GLP-1 from mouse enteroendocrine cells through glucose-independent pathways. Br J Pharmacol. 2012 Apr;165(8):2799-807. DOI:10.1111/j.1476-5381.2011.01754.x
[3] Yang JW, et al. GPR119: a promising target for nonalcoholic fatty liver disease. FASEB J. 2016 Jan;30(1):324-35. DOI:10.1096/fj.15-273771
MBX2982 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2915 | 55 | |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1490 | 55 | |
| China Kouting Group Limited | +86 (21) 5811-6473 5811-6475 | sales@koutingchina.com | China | 494 | 60 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| EnliPharma Technology Co., Ltd | 0551-66399836 18955197623 | sales@enlipharma.com | China | 1875 | 55 |
| AdooQ Bioscience CHINA | 025-58849295 | info@adooq.cn | China | 2981 | 60 |
