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1-(1-Benzothiophen-4-yl)piperazine hydrochloride

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Structure
1-(1-Benzothiophen-4-yl)piperazine hydrochloride structure
CAS No.
913614-18-3
Chemical Name:
1-(1-Benzothiophen-4-yl)piperazine hydrochloride
Synonyms
1-(benzo[b]thiophen-4-yl)piperazine hydrochloride;1-Benzo[b]thien-4-yl-piperazine hydrochloride;7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one;1-Benzo[b]thien-4-ylpiperazine Monohydrochloride;1-benzo[b]thien-4-yl-;Brexpiprazole intermediate;Brexpiprazole Intermediate 2;Brexpiprazole Impurity 9 HCl;Brexpiprazole Impurity 32 HCl;1-benzo[b]thien-4-yl-, hydrochloride
CBNumber:
CB72662777
Molecular Formula:
C12H15ClN2S
Molecular Weight:
254.78
MDL Number:
MFCD26743820
MOL File:
913614-18-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:30:00
Product description Number Pack Size Price
1-Benzo[b]thien-4-yl-piperazine Monohydrochloride TRC-B194840-5G 5g $339
1-Benzo[b]thien-4-yl-piperazine Monohydrochloride TRC-B194840-250MG 250mg $109
1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% OR305616 5g $21
1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% OR305616 25g $58
1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% OR305616 100g $224
More product size
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1-(1-Benzothiophen-4-yl)piperazine hydrochloride Properties

Melting point >250°C (dec.)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly, Heated), Methanol (Very Slightly)
form Solid
color White
InChI InChI=1S/C12H14N2S.ClH/c1-2-11(14-7-5-13-6-8-14)10-4-9-15-12(10)3-1;/h1-4,9,13H,5-8H2;1H
InChIKey XDUUWPNOUUQXBX-UHFFFAOYSA-N
SMILES N1(C2=C3C=CSC3=CC=C2)CCNCC1.[H]Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H335
Precautionary statements  P261-P271
HS Code  2934999090

1-(1-Benzothiophen-4-yl)piperazine hydrochloride price More Price(47)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC TRC-B194840-5G 1-Benzo[b]thien-4-yl-piperazine Monohydrochloride 913614-18-3 5g $339 2026-06-03 Buy
TRC TRC-B194840-250MG 1-Benzo[b]thien-4-yl-piperazine Monohydrochloride 913614-18-3 250mg $109 2026-06-03 Buy
Apolloscientific OR305616 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% 913614-18-3 5g $21 2026-06-04 Buy
Apolloscientific OR305616 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% 913614-18-3 25g $58 2026-06-04 Buy
Apolloscientific OR305616 1-(1-Benzothiophen-4-yl)piperazine hydrochloride 98% 913614-18-3 100g $224 2026-06-04 Buy
Product number Packaging Price Buy
TRC-B194840-5G 5g $339 Buy
TRC-B194840-250MG 250mg $109 Buy
OR305616 5g $21 Buy
OR305616 25g $58 Buy
OR305616 100g $224 Buy

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Chemical Properties,Uses,Production

Uses

4-Piperazinylbenzothiophene hydrochloride is the raw material for preparing piperazine-substituted benzothiophene, which can be used for the treatment and prevention of mental diseases including central nervous system diseases.

Synthesis

1.jpg
Synthesis of 4-(1-piperazinyl)benzo[b]thiophene hydrochloride 4-Chlorobenzo[b]thiophene (5.00 g), piperazine (5.11 g), palladium acetate (II) (2.7 mg), tri-tert-butylphosphonium tetraphenylborate (6.2 mg), sodium tert-butoxide (8.548 g), and xylene (70 ml) were stirred at 120 to 130°C for 5 hours. After the reaction mixture was cooled to room temperature, water was added thereto, and the layers were separated. The xylene layer was washed with water, and then with saline. After addition of activated carbon, the mixture was stirred at room temperature for 30 minutes. After filtration of the mixture, concentrated hydrochloric acid was added to the filtrate, and the resulting mixture was stirred at room temperature for 30 minutes. The precipitated crystals were collected by filtration and dried to obtain compound. Yield: 6.94 g. 1H-NMR (DMSO-d6) δ ppm; 3.30 (4H, br.s), 3.61 (4H, br.s), 6.97 (1H, d, J = 7.8 Hz), 7.32 (1H, br. dd, J = 8.4, 7.8 Hz), 7.53 (1H, d, J = 5.6 Hz), 7.70 (1H, d, J = 8.4 Hz), 7.76 (1H, d, J = 5.6 Hz), 9.37 (1H, br.s).

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Suppliers

Global( 240)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20111 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		sarah@tnjone.com China 1139 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29626 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14034 58
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497 sales01@cooperate-pharm.com CHINA 1796 55
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21531 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 32997 60
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29766 58
NINGBO INNO PHARMCHEM CO., LTD. 		13867897135 sales@nbinno.com CHINA 920 58
Jinan Shengqi pharmaceutical Co,Ltd 		86+18663751872 christine@shengqipharm.com CHINA 490 58
Supplier Advantage
Henan Fengda Chemical Co., Ltd 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Beijing Cooperate Pharmaceutical Co.,Ltd 		55
Henan Tianfu Chemical Co.,Ltd. 		55
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
NINGBO INNO PHARMCHEM CO., LTD. 		58
Jinan Shengqi pharmaceutical Co,Ltd 		58

View Lastest Price from 1-(1-Benzothiophen-4-yl)piperazine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-(1-Benzothiophen-4-yl)piperazine hydrochloride pictures 2026-08-14 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
913614-18-3
 $35.00 1kg 99% Henan Fengda Chemical Co., Ltd
1-Benzo[b]thien-4-ylpiperazine monohydrochloride pictures 2026-08-14 1-Benzo[b]thien-4-ylpiperazine monohydrochloride
913614-18-3
 10g 99% 100mt/year Jinan Finer Chemical Co., Ltd
1-(1-Benzothiophen-4-yl)piperazine hydrochloride pictures 2026-06-30 1-(1-Benzothiophen-4-yl)piperazine hydrochloride
913614-18-3
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

1-(1-Benzothiophen-4-yl)piperazine hydrochloride Spectrum

1-(1-Benzothiophen-4-yl)piperazine hydrochloride(913614-18-3)1HNMR

913614-18-3(1-(1-Benzothiophen-4-yl)piperazine hydrochloride)Related Search:

2(1H)-Quinolinone, 7-(3-chloropropoxy)- Brexpiprazole Impurity Brexpiprazole N-Oxide 7-(4-BROMOBUTOXY)-QUINOLINE-2(1H)-ONE 4-chloro- Benzo[b]thiophene
Cinnamoyl chloride 4-CHLORO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID 7-Hydroxyquinolinone 1,4-di(benzo[b]thiophen-4-yl)piperazine 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Brexpiprazole Impurity 19 Brexpiprazole 2(1H)-Quinolinone,7-(4-chlorobutoxy)- 7,7'-(butane-1,4-diylbis(oxy))bis(quinolin-2(1H)-one) 5-HYDROXY-2(1H)-QUINOLINONE
(E)-N-(3-METHOXY-PHENYL)-3-PHENYL-ACRYLAMIDE 7-(4-chlorobutoxy)-1-{4-[(2-oxo-1,2-dihydroquinolin-7-yl)oxy]butyl}-1,2-dihydroquinolin-2-one Brexpiprazole Impurity 5 HCl

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Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride 1-Benzo[b]thien-4-yl-piperazine hydrochloride Brexpiprazole Intermediate 2 1-benzo[b]thien-4-yl- 1-benzo[b]thien-4-yl-, hydrochloride 1-Benzo[b]thien-4-ylpiperazine Monohydrochloride 1-(1-benzothiophen-4-yl)piperazine hydrochloride 7-(4-chlorobutoxy)-1-(4-chlorobutyl)quinolin-2(1H)-one 1-Benzo[b]thien-4-yl-piperazinel HCl 1-(1-benzothiophene-4-yl)piperazine monohydrochloride PIPERAZINE, 1-BENZO[B]THIEN-4-YL,HYDROCLORIDE 1-(1-Benzothiophene-4-Yl)Piperazine Hydrochloroide - 1-(4-Benzothienyl)piperazine Hydrochloride Piperazine, 1-benzo[b]thien-4-yl-, hydrochloride (1:1) Brexpiprazole intermediate 1-Benzo[b] thien-4-yl-piperzine hydrochloride 1-benzo[b]thiophene-4-yl-piperazine hydrochloride 1-(1-benzo[b]thien-4-yl )piperazine hydrochloride 1-benzo[b]thien-4-yl-Piperazine hydrochloride (1:1) Brexpiprazole Impurity 32 HCl 4-piperazinyl benzothiophene hydrochloride Brexpiprazole Impurity 11 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride Brexpiprazole Impurity 9 HCl 1-(Benzo[b]thiophen-4-yl)piperazine hydrochloride - [B71906] 1-Benzo[b]thiophen-4-yl-piperazine HCl 1-(benzenebenzo[b]thiophene-4-yl)azinehydrochloride 1-(benzo[b]thiophen-4-yl)piperazine hydrochloride 913614-18-3