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2-Methylindoline

2-Methylindoline Structure
2-Methylindoline structure
CAS No.
6872-06-6
Chemical Name:
2-Methylindoline
Synonyms
2,3-Dihydro-2-methyl-1H-indole;PE-11;NSC 65598;2-methyl-indolin;2-METHYLINDOLINE;Indoline, 2-methyl-;2-Methylindoline>2-Methyl-1H-indoline;α-Methyldihydroindole;a-Methyldihydroindole
CBNumber:
CB8169273
Molecular Formula:
C9H11N
Molecular Weight:
133.19
MDL Number:
MFCD00005706
MOL File:
6872-06-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-22 13:06:06
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2-Methylindoline Properties

Melting point -51 °C
Boiling point 228-229 °C (lit.)
Density 1.023 g/mL at 25 °C (lit.)
refractive index n20/D 1.569(lit.)
Flash point 200 °F
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Chloroform, Methanol
form Liquid
pka 5.26±0.40(Predicted)
Specific Gravity 1.02
color Clear yellow to brown
optical activity -2.4550° (C=1.0 g/100ml, MEOH, 20°C, 589nm)
Water Solubility negligible
InChI 1S/C9H11N/c1-7-6-8-4-2-3-5-9(8)10-7/h2-5,7,10H,6H2,1H3
InChIKey QRWRJDVVXAXGBT-UHFFFAOYSA-N
SMILES CC1Cc2ccccc2N1
CAS DataBase Reference 6872-06-6(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 5GAL2SM4VV
NIST Chemistry Reference 2-Methylindoline(6872-06-6)
EPA Substance Registry System 1H-Indole, 2,3-dihydro-2-methyl- (6872-06-6)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Environment (GHS09)
GHS06,GHS09
Signal word  Danger
Hazard statements  H302-H311-H319-H400
Precautionary statements  P264-P273-P280-P301+P312-P302+P352+P312-P305+P351+P338
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-52/53-22
Safety Statements  26-36/37/39-60-57
WGK Germany  3
RTECS  NM1926350
Hazard Note  Irritant
TSCA  TSCA listed
HS Code  29349990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 4 Oral
Aquatic Acute 1
Eye Irrit. 2
REACH Registrations Active
NFPA 704
1
2 0

2-Methylindoline price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical M0871 2-Methylindoline >98.0%(GC) 6872-06-6 25mL $55 2026-04-30 Buy
Usbiological 281580 2-Methylindoline Asreported 5g $263 2026-06-03 Buy
Usbiological 281580 2-Methylindoline Asreported 10g $345 2026-06-03 Buy
Usbiological 281580 2-Methylindoline Asreported 25g $430 2026-06-03 Buy
Usbiological 281580 2-Methylindoline Asreported 50g $525 2026-06-03 Buy
Product number Packaging Price Buy
M0871 25mL $55 Buy
281580 5g $263 Buy
281580 10g $345 Buy
281580 25g $430 Buy
281580 50g $525 Buy

2-Methylindoline Chemical Properties, Uses, Production

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

2-Methylindoline is an intermediate in the production of various indole derivatives

Uses

Reactant for preparation of:

  • Inhibitors of NOD1-induced nuclear factor-κB activation
  • Red fluorescent dyes for organic light-emitting diodes
  • Norepinephrine reuptake inhibitors
  • MT2-selective melatonin receptor antagonists
  • Protease-activated receptor-1 antagonists
  • Diuretic agent indapamide
  • Dopamine D2/D4 receptor antagonists
  • Antitumor agents

Definition

ChEBI: 2-Methylindoline is a member of indoles.

Preparation

2-Methylindoline is prepared through the transformation of 1-(2-aminophenyl)propan-2-ol using acidic catalysts[1]. 2-Methylindoline is also produced by the hydrogenation of 2-methylindole in toluene[2].

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 4108, 1989 DOI: 10.1021/ja00193a056
Chemical and Pharmaceutical Bulletin, 26, p. 108, 1978 DOI: 10.1248/cpb.26.108

References

[1] Heidi Bernas. (2015). Transformations of 1-(2-Aminophenyl)propan-2-ol to 2-Methylindoline. Catalysis Letters, 145 3, 955–963. https://doi.org/10.1007/s10562-014-1474-3
[2] Heidi Bernas . (2014). Hydrogenation of 2-methylindole using supported metal catalysts. Catalysis Communications, 56, Pages 41-44. https://doi.org/10.1016/j.catcom.2014.07.001

2-Methylindoline synthesis

131880-76-7
54813-73-9
6872-06-6
Synthesis of 2-Methylindoline from 1-(2,3-dihydro-2-Methyl-1H-indol-1-yl)-Ethanone

2-Methylindoline Preparation Products And Raw materials

Raw materials

2-Methylindole Benzenamine, 2-(2-propyn-1-yl)- Benzenamine, 2-(2-propenyl)- N-Allylaniline 1-(2-bromophenyl)propan-2-amine

Preparation Products

Basic Yellow 21 1H-Indole, 1-ethyl-2,3-dihydro-2-methyl- 5-Bromo-2-methylindole

2-Methylindoline Suppliers

Global Suppliers ( 321)
Supplier Tel Email Country ProdList Advantage
Shandong Dinghao Biological Technology Co. LTD 0531-82616988 18300239268 xinhuang@sddhpharm.com China 92 58
Jinan zhongdaoanran chemical Co;Ltd 18678233466; 18678233466 122574856@qq.com China 195 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
TAIYUAN RHF CO.,LTD. +86 351 7031519 sales@RHFChem.com China 2334 56
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Supplier Advantage
Shandong Dinghao Biological Technology Co. LTD 58
Jinan zhongdaoanran chemical Co;Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
TAIYUAN RHF CO.,LTD. 56
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Capot Chemical Co., Ltd 66
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62

View Latest Price from 2-Methylindoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Methylindoline pictures 2026-09-16 2-Methylindoline
6872-06-6
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Methylindoline pictures 2026-06-30 2-Methylindoline
6872-06-6
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
2-Methylindoline pictures 2026-02-02 2-Methylindoline
6872-06-6
 1g 99% 2000tons Shaanxi Dideu Medichem Co. Ltd

2-Methylindoline Spectrum

2-Methylindoline(6872-06-6)1HNMR2-Methylindoline(6872-06-6)Raman2-Methylindoline(6872-06-6)FT-IR2-Methylindoline(6872-06-6)IR

6872-06-6 (2-Methylindoline) Related Search:

3-Methylindole Tetramethylammonium hydroxide Benzyltrimethylammonium hydroxide 2-Methylindole Poly(methylhydrosiloxane)
Methyl tetrahydrophthalic anhydride cis-Octahydroisoindole Methylhexahydrophthalic anhydride 5-Methylindole 1-Methylindole
Isoindoline Indoline Indapamide IndapaMide iMpurity 5 4-Chloro-3-sulfamoylbenzoyl chloride
INDAPAMIDE RELATED COMPOUND A (50 MG) (4-CHLORO-N-(2-METHYL-INDOL-1-YL)-3-SULFAMOYLBEN-ZAMIDE) (AS) (±)-2-methyl-1-nitrosoindoline 5-hydroxyindapamide

1of4

1H-Indole, 2,3-dihydro-2-methyl- 1H-Indole,2,3-dihydro-2-methyl- 2,3-dihydro-2-methyl-1h-indol 2,3-Dihydro-2-methyl-1H-indole 2-Methyl-2,3-dihydroindole 2-methyl-indolin alpha-Methyldihydroindole Dihydroindole, 2-methyl- Indoline, 2-methyl- PE-11 2,3-DIHYDRO-2-METHYLINDOLE 2-METHYL-2,3-DIHYDRO-1H-INDOLE 2-METHYLINDOLINE 2-Methylindoline, 99+% 2-Methylindoline ,99.5% 2-Methylindoline CAS6872-06-6 IndapaMide Related CoMpound C NSC 65598 α-Methyldihydroindole (R,S)-2-Methyl-2,3-dihydro-1H-indole 2-Methylindoline, 98.5% 2-Methylindoline in stock Factory Indapamide Impurity 15 (2-methylindoline) 2-Methylindoline> 2-Methyl-1H-indoline a-Methyldihydroindole Indoline,2-methyl- (6CI,7CI,8CI) TIANFU-CHEM - 2-Methylindoline Indapamide Related Compound C (2-Methylindoline) (1338834) Indapamide USP Related Compound C 2-Methylindoline CAS NO.: 6872-06-6 6872-06-6 6872-6-6 6873-06-6 6875-06-6 1816-14-5 Building Blocks Heterocyclic Building Blocks Indoles AMINE Building Blocks Heterocyclic Building Blocks Indoles pharmacetical Indoline & Oxindole Heterocyclic Compounds Heterocycle-Indole series intermediates Indoles and derivatives