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1-TRIMETHYLSILYLMETHANOL

1-TRIMETHYLSILYLMETHANOL structure

CAS No.: 3219-63-4

Chemical Name:: 1-TRIMETHYLSILYLMETHANOL

Synonyms: DK264;NSC 96777;rimethylsilylmethanol;(trimethylsilyl)-methano;1-TRIMETHYLSILYLMETHANOL;(TRIMETHYLSILYL)METHANOL;Methanol, (trimethylsilyl)-;TRIMETHYLHYDROXYMETHYLSILANE;Methanol,1-(trimethylsilyl)-;1-TRIMETHYLSILYLMETHANOL, 98+%

CBNumber:: CB7284458

Molecular Formula:: C4H12OSi

Molecular Weight:: 104.22

MDL Number:: MFCD00004596

MOL File:: 3219-63-4.mol

MSDS File:: SDS

Last updated:2026-01-13 11:26:03

Product description	Number	Pack Size	Price
Trimethylsilylmethanol >97.0%(GC)	T1250	5mL	$102
Trimethylsilylmethanol >97.0%(GC)	T1250	25mL	$350
Trimethylsilylmethanol	291767	2g	$313
1-Trimethylsilylmethanol	6180-1-02	5G	$199
(TRIMETHYLSILYL)METHANOL 95.00%	ORS0005292	1ML	$612.27
More product size

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1-TRIMETHYLSILYLMETHANOL Properties

Melting point	<0°C
Boiling point	120-122 °C754 mm Hg(lit.)
Density	0.826 g/mL at 25 °C(lit.)
refractive index	n20/D 1.419(lit.)
Flash point	88 °F
storage temp.	2-8°C
pka	15.92±0.10(Predicted)
form	clear liquid
color	Colorless to Almost colorless
Specific Gravity	0.827
Water Solubility	Fully miscible in water.
Hydrolytic Sensitivity	1: no significant reaction with aqueous systems
BRN	1731486
InChI	1S/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3
InChIKey	ZQKNBDOVPOZPLY-UHFFFAOYSA-N
SMILES	C[Si](C)(C)CO
CAS DataBase Reference	3219-63-4(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	E19993083K
EPA Substance Registry System	Methanol, (trimethylsilyl)- (3219-63-4)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Warning

Hazard statements

H226-H315-H319-H335

Precautionary statements

P261-P305+P351+P338-P210-P240-P241-P280a-P303+P361+P353-P501a

target organs

Respiratory system

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

RIDADR

UN 1987 3/PG 3

WGK Germany

RTECS

PC4100000

TSCA

TSCA listed

HS Code

2931.90.9010

HazardClass

PackingGroup

III

Storage Class

3 - Flammable liquids

Hazard Classifications

Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3

NFPA 704

	2
0		0

1-TRIMETHYLSILYLMETHANOL price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	T1250	Trimethylsilylmethanol >97.0%(GC)	3219-63-4	5mL	$102	2025-07-31	Buy
TCI Chemical	T1250	Trimethylsilylmethanol >97.0%(GC)	3219-63-4	25mL	$350	2025-07-31	Buy
Usbiological	291767	Trimethylsilylmethanol	3219-63-4	2g	$313	2021-12-16	Buy
SynQuest Laboratories	6180-1-02	1-Trimethylsilylmethanol	3219-63-4	5G	$199	2021-12-16	Buy
American Custom Chemicals Corporation	ORS0005292	(TRIMETHYLSILYL)METHANOL 95.00%	3219-63-4	1ML	$612.27	2021-12-16	Buy

Product number	Packaging	Price	Buy
T1250	5mL	$102	Buy
T1250	25mL	$350	Buy
291767	2g	$313	Buy
6180-1-02	5G	$199	Buy
ORS0005292	1ML	$612.27	Buy

1-TRIMETHYLSILYLMETHANOL Chemical Properties,Uses,Production

Uses

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Purification Methods

If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.]

1-TRIMETHYLSILYLMETHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

(TRIMETHYLSILYL)METHYL TRIFLUOROMETHANESULFONATE TRIMETHYLSILYLMETHYL ACETATE

1-TRIMETHYLSILYLMETHANOL Suppliers

Global( 155)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13676	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Hubei Co-Formula Material Tech Co., Ltd.	+86-27-84459282	sales@cfmats.com	CHINA	882	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
Win-Win chemical CO., Limited	+86-0086-577-64498589 +86-15355981851	sales@win-winchemical.com	China	14343	58
Aston Chemical	13000000000	sales@astonchem.com	United States	1634	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58

Supplier	Advantage
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
career henan chemical co	58
Hubei Co-Formula Material Tech Co., Ltd.	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Win-Win chemical CO., Limited	58
Aston Chemical	58
Dayang Chem (Hangzhou) Co.,Ltd.	58

View Lastest Price from 1-TRIMETHYLSILYLMETHANOL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-01	1-TRIMETHYLSILYLMETHANOL 3219-63-4	US $0.00 / kg	1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
	2019-12-20	1-TRIMETHYLSILYLMETHANOL 3219-63-4	US $1.00 / KG	1KG	99%	KG/T	Career Henan Chemical Co

1-TRIMETHYLSILYLMETHANOL
3219-63-4
US $0.00 / kg
98%
Shaanxi Dideu New Materials Co. Ltd

1-TRIMETHYLSILYLMETHANOL
3219-63-4
US $1.00 / KG
99%
Career Henan Chemical Co

1-TRIMETHYLSILYLMETHANOL Spectrum

1-TRIMETHYLSILYLMETHANOL(3219-63-4)MS 1-TRIMETHYLSILYLMETHANOL(3219-63-4)¹HNMR 1-TRIMETHYLSILYLMETHANOL(3219-63-4)¹³CNMR 1-TRIMETHYLSILYLMETHANOL(3219-63-4)IR1 1-TRIMETHYLSILYLMETHANOL(3219-63-4)Raman

3219-63-4(1-TRIMETHYLSILYLMETHANOL)Related Search:

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1-TRIMETHYLSILYLMETHANOL (TRIMETHYLSILYL)METHYL TRIFLUOROMETHANESULFONATE 1-(TRIMETHYLSILYL)ETHANOL, 98 (METHOXYMETHYL)TRIMETHYLSILANE (1-ETHOXYVINYL)-TRIMETHYLSILANE

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(2',5'-bis-O-(tert-butyldimethylsilyl)-beta-ribofuranosyl)-3'-spiro-5''-(4''-amino-1'',2''-oxathiole-2'',2''-dioxide)thymine (1-METHOXYVINYL)TRIMETHYLSILANE TRIMETHYLSILYLMETHYL ACETATE

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(hydroxymethyl)trimethyl-silan (trimethylsilyl)-methano Methanol, (trimethylsilyl)- Silane, (hydroxymethyl)trimethyl- TRIMETHYLHYDROXYMETHYLSILANE (TRIMETHYLSILYL)METHANOL 1-TRIMETHYLSILYLMETHANOL (HYDROXYMETHYL)TRIMETHYLSILANE 1-TRIMETHYLSILYLMETHANOL, 98+% (Trimethylsilyl)methanol,(Hydroxymethyl)trimethylsilane NSC 96777 Methanol,1-(trimethylsilyl)- rimethylsilylmethanol DK264 3219-63-4 C4H12OSi CH33SiCH2OH Alcohols Building Blocks C2 to C6 Organic Building Blocks Oxygen Compounds Silicon Compounds (for Synthesis) Si (Classes of Silicon Compounds) Si-(C)4 Compounds Si (Classes of Silicon Compounds) Si-(C)4 Compounds Silicon Compounds (for Synthesis) Synthetic Organic Chemistry