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1-Trimethylsilylmethanol

1-Trimethylsilylmethanol Structure
1-Trimethylsilylmethanol structure
CAS No.
3219-63-4
Chemical Name:
1-Trimethylsilylmethanol
Synonyms
(TRIMETHYLSILYL)METHANOL;DK264;NSC 96777;rimethylsilylmethanol;(trimethylsilyl)-methano;1-Trimethylsilylmethanol;Methanol, (trimethylsilyl)-;Methanol,1-(trimethylsilyl)-;TRIMETHYLHYDROXYMETHYLSILANE;1-TRIMETHYLSILYLMETHANOL, 98+%
CBNumber:
CB7284458
Molecular Formula:
C4H12OSi
Molecular Weight:
104.22
MDL Number:
MFCD00004596
MOL File:
3219-63-4.mol
MSDS File:
SDS
Last updated:2026-09-12 18:54:54
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1-Trimethylsilylmethanol Properties

Melting point <0°C
Boiling point 120-122 °C754 mm Hg(lit.)
Density 0.826 g/mL at 25 °C(lit.)
refractive index n20/D 1.419(lit.)
Flash point 88 °F
storage temp. 2-8°C
pka 15.92±0.10(Predicted)
form clear liquid
color Colorless to Almost colorless
Specific Gravity 0.827
Water Solubility Fully miscible in water.
Hydrolytic Sensitivity 1: no significant reaction with aqueous systems
BRN 1731486
InChI 1S/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3
InChIKey ZQKNBDOVPOZPLY-UHFFFAOYSA-N
SMILES C[Si](C)(C)CO
CAS DataBase Reference 3219-63-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII E19993083K
EPA Substance Registry System Methanol, (trimethylsilyl)- (3219-63-4)
UNSPSC Code 12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)Exclamation Mark (GHS07)
GHS02,GHS07
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P261-P305+P351+P338-P210-P240-P241-P280a-P303+P361+P353-P501a
target organs Respiratory system
PPE Eyeshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
RIDADR  UN 1987 3/PG 3
WGK Germany  3
RTECS  PC4100000
TSCA  TSCA listed
HS Code  2931.90.9010
HazardClass  3
PackingGroup  III
Storage Class 3 - Flammable liquids
Hazard Classifications Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3
NFPA 704
2
0 0

1-Trimethylsilylmethanol price More Price(27)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical T1250 Trimethylsilylmethanol >97.0%(GC) 3219-63-4 5mL $82 2026-04-30 Buy
TCI Chemical T1250 Trimethylsilylmethanol >97.0%(GC) 3219-63-4 25mL $280 2026-04-30 Buy
Usbiological 291767 Trimethylsilylmethanol Asreported 3219-63-4 2g $313 2026-06-03 Buy
Usbiological 291767 Trimethylsilylmethanol Asreported 3219-63-4 5g $448 2026-06-03 Buy
Usbiological 291767 Trimethylsilylmethanol Asreported 3219-63-4 10g $613 2026-06-03 Buy
Product number Packaging Price Buy
T1250 5mL $82 Buy
T1250 25mL $280 Buy
291767 2g $313 Buy
291767 5g $448 Buy
291767 10g $613 Buy

1-Trimethylsilylmethanol Chemical Properties, Uses, Production

Uses

1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Purification Methods

If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.]

1-Trimethylsilylmethanol Preparation Products And Raw materials

Raw materials

Preparation Products

(Trimethylsilyl)methyl trifluoromethanesulfonate Trimethylsilylmethyl acetate

1-Trimethylsilylmethanol Suppliers

Global Suppliers ( 150)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
China DongFan Chemical Co.,LTD 86-0571-85151182 China 5681 66
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Sichuan Kulinan Technology Co., Ltd 400-1166-196 18981987031 cdhxsj@163.com China 11674 57
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
ChemFuture PharmaTech (Jiangsu) Ltd 65
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Shanghai Hanhong Scientific Co.,Ltd. 64
China DongFan Chemical Co.,LTD 66
Shandong Xiya Chemical Co., Ltd 57
Sichuan Kulinan Technology Co., Ltd 57

View Latest Price from 1-Trimethylsilylmethanol manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-TRIMETHYLSILYLMETHANOL pictures 2026-06-30 1-TRIMETHYLSILYLMETHANOL
3219-63-4
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
1-TRIMETHYLSILYLMETHANOL pictures 2019-12-20 1-TRIMETHYLSILYLMETHANOL
3219-63-4
 $1.00 1KG 99% Career Henan Chemical Co

1-Trimethylsilylmethanol Spectrum

1-TRIMETHYLSILYLMETHANOL(3219-63-4)MS1-TRIMETHYLSILYLMETHANOL(3219-63-4)1HNMR1-TRIMETHYLSILYLMETHANOL(3219-63-4)13CNMR1-TRIMETHYLSILYLMETHANOL(3219-63-4)IR11-TRIMETHYLSILYLMETHANOL(3219-63-4)Raman

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(hydroxymethyl)trimethyl-silan (trimethylsilyl)-methano Methanol, (trimethylsilyl)- Silane, (hydroxymethyl)trimethyl- TRIMETHYLHYDROXYMETHYLSILANE (HYDROXYMETHYL)TRIMETHYLSILANE 1-TRIMETHYLSILYLMETHANOL, 98+% (Trimethylsilyl)methanol,(Hydroxymethyl)trimethylsilane NSC 96777 Methanol,1-(trimethylsilyl)- rimethylsilylmethanol DK264 (TRIMETHYLSILYL)METHANOL 1-Trimethylsilylmethanol 3219-63-4 C4H12OSi CH33SiCH2OH Alcohols Building Blocks C2 to C6 Organic Building Blocks Oxygen Compounds Silicon Compounds (for Synthesis) Si (Classes of Silicon Compounds) Si-(C)4 Compounds Si (Classes of Silicon Compounds) Si-(C)4 Compounds Silicon Compounds (for Synthesis) Synthetic Organic Chemistry