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| | 1-Trimethylsilylmethanol Basic information |
| | 1-Trimethylsilylmethanol Chemical Properties |
| Melting point | <0°C | | Boiling point | 120-122 °C754 mm Hg(lit.) | | density | 0.826 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.419(lit.) | | Fp | 88 °F | | storage temp. | 2-8°C | | pka | 15.92±0.10(Predicted) | | form | clear liquid | | color | Colorless to Almost colorless | | Specific Gravity | 0.827 | | Water Solubility | Fully miscible in water. | | Hydrolytic Sensitivity | 1: no significant reaction with aqueous systems | | BRN | 1731486 | | InChI | 1S/C4H12OSi/c1-6(2,3)4-5/h5H,4H2,1-3H3 | | InChIKey | ZQKNBDOVPOZPLY-UHFFFAOYSA-N | | SMILES | C[Si](C)(C)CO | | CAS DataBase Reference | 3219-63-4(CAS DataBase Reference) | | EPA Substance Registry System | Methanol, (trimethylsilyl)- (3219-63-4) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | UN 1987 3/PG 3 | | WGK Germany | 3 | | RTECS | PC4100000 | | TSCA | TSCA listed | | HS Code | 2931.90.9010 | | HazardClass | 3 | | PackingGroup | III | | Storage Class | 3 - Flammable liquids | | Hazard Classifications | Eye Irrit. 2
Flam. Liq. 3
Skin Irrit. 2
STOT SE 3 |
| | 1-Trimethylsilylmethanol Usage And Synthesis |
| Uses | 1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent. | | Purification Methods | If the NMR indicates impurities (should have only two signals), then dissolve it in Et2O, shake this with aqueous 5N NaOH, M H2SO4, saturated aqueous NaCl, dry (MgSO4) and distil it using an efficient column at atmospheric pressure. The 3,5-dinitrobenzoate has m 70-70.5o (from 95% EtOH). [Huang & Wang Acta Chem Sin 23 291 1957, cf. Chem Abstr 52 19911 1958, Speier et al. J Am Chem Soc 81 1844 1959 and Speier et al. J Am Chem Soc 70 1117 1948, Beilstein 4 III 1844, 4 IV 2876.] |
| | 1-Trimethylsilylmethanol Preparation Products And Raw materials |
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