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(+)-AEROPLYSININ-1

(+)-AEROPLYSININ-1 structure

CAS No.: 28656-91-9

Chemical Name:: (+)-AEROPLYSININ-1

Synonyms: NSC-170364;AEROPLYSININ;aeroplysinini;(+)-aeroplysinini;(+)-AEROPLYSININ-1;(+)--Aeroplysinin-1;(+)shy-Aeroplysinin-1;Aeroplysinin (Aeroplysinin-1);AEROPLYSININ, APLYSINA AEROPHOBA;(+)-AEROPLYSININ-1, APLYSINA AEROPHOBA

CBNumber:: CB7286568

Molecular Formula:: C9H9Br2NO3

Molecular Weight:: 338.98

MDL Number:: MFCD01745659

MOL File:: 28656-91-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:27

Product description	Number	Pack Size	Price
(+)-Aeroplysinin-1 ≥95%	21498	100μg	$129
(+)-Aeroplysinin-1 ≥95%	21498	100μg	$117
Aeroplysinin 1 95.0%	CS-0016895	100??g	$448
Aeroplysinin 1 95.0%	CS-0016895	100??g	$448
(+)-Aeroplysinin-1 >95%	AA002VWU	1mg	$999

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(+)-AEROPLYSININ-1 Properties

Boiling point	479.6±45.0 °C(Predicted)
Density	2.01±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Methanol: Soluble
form	A solid
pka	10.54±0.70(Predicted)
color	Colorless to off-white

SAFETY

Risk and Safety Statements

HS Code	2941900000

(+)-AEROPLYSININ-1 price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21498	(+)-Aeroplysinin-1 ≥95%	28656-91-9	100μg	$129	2026-04-30	Buy
Cayman Chemical	21498	(+)-Aeroplysinin-1 ≥95%	28656-91-9	100μg	$117	2024-03-01	Buy
ChemScene	CS-0016895	Aeroplysinin 1 95.0%	28656-91-9	100??g	$448	2026-06-04	Buy
ChemScene	CS-0016895	Aeroplysinin 1 95.0%	28656-91-9	100??g	$448	2026-06-04	Buy
aablocks	AA002VWU	(+)-Aeroplysinin-1 >95%	28656-91-9	1mg	$999	2026-05-28	Buy

Product number	Packaging	Price	Buy
21498	100μg	$129	Buy
21498	100μg	$117	Buy
CS-0016895	100??g	$448	Buy
CS-0016895	100??g	$448	Buy
AA002VWU	1mg	$999	Buy

(+)-AEROPLYSININ-1 Chemical Properties,Uses,Production

Description

(+)-Aeroplysinin-1 is a metabolite originally isolated from the marine sponge V. aerophoba with diverse biological activities. (+)-Aeroplysinin-1 (0.25-0.5 μM) induces cell death in MCF-7 and ZR-75-1 human breast cancer cells in a time- and concentration-dependent manner but has no effect on normal human fibroblasts at concentrations up to 5 μM. It also blocks EGF-induced endocytosis of the EGF receptor (EGFR) and EGF-dependent cell proliferation in MCF-7 cells. (+)-Aeroplysinin-1 inhibits bovine aortic endothelial (BAE) cell proliferation and cord formation in a Matrigel™ assay. It inhibits angiogenesis in a dose-dependent manner in a chick chorioallantoic membrane (CAM) assay when administered from 1.5 to 3 nmol per egg. (+)-Aeroplysinin-1 also has antibacterial activity against Gram-positive bacteria, including S. aureus, S. albus, and B. subtilis, but not Gram-negative bacteria and inhibits HIV-1 replication (IC₅₀ = 14.6 μM) via inhibition of HIV-1 reverse transcriptase.

Uses

(+)shy-Aeroplysinin-1 is a compound that is an inhibitor of EGFR kinase.

Definition

ChEBI: Aeroplysinin 1 is a tertiary alcohol.

IC 50

Bacterial; HIV-1: 14.6 μM (IC₅₀); Apoptosis

References

[1] E FATTORUSSO G S L Minale. Aeroplysinin-1, an antibacterial bromo-compound from the sponge Verongia aerophoba.[J]. Journal of the Chemical Society. Perkin transactions 1, 1972, 1: 16-18. DOI: 10.1039/p19720000016
[2] MATTHIAS-H. KREUTER . Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1[J]. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1990, 97 1: Pages 151-158. DOI: 10.1016/0305-0491(90)90194-x
[3] SALVADOR RODRíGUEZ-NIETO. Antiangiogenic activity of aeroplysinin-1, a brominated compound isolated from a marine sponge[J]. FASEB Journal, 2001, 16 2: 1-27. DOI: 10.1096/fj.01-0427fje
[4] JAVIER A. GARCíA-VILAS. Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug[J]. Marine Drugs, 2015, 14 1. DOI: 10.3390/md14010001

(+)-AEROPLYSININ-1 Preparation Products And Raw materials

Raw materials

Preparation Products

(+)-AEROPLYSININ-1 Suppliers

Global( 53)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32466	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
DAYANG CHEM (HANGZHOU) CO.,LTD	+86-88938639 +86-17705817739	info@dycnchem.com	China	53803	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9891	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9804	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11218	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24959	58
Shanghai Tachizaki Biomedical Research Center	18014399201	sales@chemlab-tachizaki.com	China	2945	58
Shanghai Yiyan Biotechnology Co. , Ltd.	021-69985186 13611928337	3427709316@qq.com	China	7982	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
DAYANG CHEM (HANGZHOU) CO.,LTD	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
Shanghai EFE Biological Technology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Energy Chemical	58
TargetMol Chemicals Inc.	58
Shanghai Tachizaki Biomedical Research Center	58
Shanghai Yiyan Biotechnology Co. , Ltd.	58

28656-91-9((+)-AEROPLYSININ-1)Related Search:

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(S)-3-Bromo-1,2-propanediol 5-BROMOVALERONITRILE (E)-2-BROMO-2-BUTEN-1-OL (+)-AEROPLYSININ-1 3-Bromo-3-buten-1-ol

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1of3

(+)-aeroplysinini (1s-trans)-3,5-dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonit 4-cyclohexadiene-1-acetonitrile,3,5-dibromo-1,6-dihydroxy-4-methoxy-(1s-tr aeroplysinini AEROPLYSININ (+)-AEROPLYSININ-1 (+)-AEROPLYSININ-1, APLYSINA AEROPHOBA AEROPLYSININ, APLYSINA AEROPHOBA (1S)-1,6α-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1α-acetonitrile [1S,6R,(+)]-3,5-Dibromo-1,6-dihydroxy-4-methoxy-2,4-cyclohexadiene-1-acetonitrile NSC-170364 (1R)-1,6β-Dihydroxy-3,5-dibromo-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile (1R)-3,5-Dibromo-1α,6β-dihydroxy-4-methoxy-2,4-cyclohexadiene-1β-acetonitrile Aeroplysinin (Aeroplysinin-1) (+)shy-Aeroplysinin-1 2,4-Cyclohexadiene-1-acetonitrile, 3,5-dibromo-1,6-dihydroxy-4-methoxy-, (1S,6R)- Aeroplysinin (Aeroplysinin-1), antiangiogenic agent (+)--Aeroplysinin-1 28656-91-9 C9H9Br2NO3