8-Bromoxanthine
- CAS No.
- 10357-68-3
- Chemical Name:
- 8-Bromoxanthine
- Synonyms
- NSC 24131;8-Bromoxanthine;Zopiclone Impurity 35;8-Bromopurine-2,6-diol;8-BROMOXANTHINE USP/EP/BP;8-Bromo-1H-purine-2,6(3H,7H);8-BroMo-1H-purine-2,6(3H,7H)-dione;8-bromo-3,7-dihydropurine-2,6-dione;8-Bromo-3,9-dihydro-1H-purin-2,6-dione;8-Bromo-3,9-dihydro-1H-purine-2,6-dione
- CBNumber:
- CB7288441
- Molecular Formula:
- C5H3BrN4O2
- Molecular Weight:
- 231.01
- MDL Number:
- MFCD22123145
- MOL File:
- 10357-68-3.mol
- MSDS File:
- SDS
| Melting point | >297°C (dec.) |
|---|---|
| Density | 2.118±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO, Methanol |
| form | Solid |
| pka | 6.87±0.70(Predicted) |
| color | Off-White to Pale Beige |
| InChI | InChI=1S/C5H3BrN4O2/c6-4-7-1-2(8-4)9-5(12)10-3(1)11/h(H3,7,8,9,10,11,12) |
| InChIKey | ZFQWSCZYQLPFFZ-UHFFFAOYSA-N |
| SMILES | N1C2=C(NC(=O)NC2=O)NC=1Br |
| FDA UNII | 1JQ13K1223 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H319 |
| Precautionary statements | P280-P305+P351+P338 |
8-Bromoxanthine price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S359041 | 8-BROMOTHEOPHYLLINE AldrichCPR | 10357-68-3 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | S359041 | 8-BROMOTHEOPHYLLINE Aldrich | 10357-68-3 | 1g | $179 | 2024-03-01 | Buy |
| TRC | TRC-B689180-25G | 8-Bromoxanthine | 10357-68-3 | 25g | $1591 | 2026-06-03 | Buy |
| TRC | TRC-B689180-2.5G | 8-Bromoxanthine | 10357-68-3 | 2.5g | $202 | 2026-06-03 | Buy |
| TRC | TRC-B689180-1G | 8-Bromoxanthine | 10357-68-3 | 1g | $154 | 2026-06-03 | Buy |
8-Bromoxanthine Chemical Properties,Uses,Production
Uses
8-Bromoxanthine is used to study Arsenite-inhibited xanthine oxidase.
Uses
8-Bromoxanthine is used to study Arsenite-inhibited xanthine oxidase.
Synthesis
69-89-6
10357-68-3
General procedure for the synthesis of 8-bromo-1H-purine-2,6(3H,7H)-dione using 1H-purine-2,6(3H,7H)-dione as a raw material: weigh 15g of 1H-purine-2,6(3H,7H)-dione in a 250mL reaction flask, add 250mL of deionized water, and stir until complete dissolution. 7.6 mL of liquid bromine was added slowly dropwise, and the rate of dropwise acceleration was controlled to avoid violent reaction. The reaction mixture was heated to 100 °C and stirring was maintained until the color of the reaction solution faded completely from the red color of the bromine, indicating that the reaction was complete. The heating was stopped and the reaction mixture was cooled to room temperature. The reaction mixture was washed with a small amount of ice water to remove unreacted bromine. Subsequently, the reaction mixture was diafiltered and the solid product was collected. The filter cake was dried in a vacuum drying oven to give 18.4 g of 8-bromo-1H-purine-2,6(3H,7H)-dione.
References
[1] Justus Liebigs Annalen der Chemie, 1883, vol. 221, p. 344
[2] Patent: CN103172633, 2016, B. Location in patent: Paragraph 0145-0147
8-Bromoxanthine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| NANJING DAOGE BIOPHARMA CO.,LTD. | 025-58227606 18021503536 | sale@daogepharm.com | China | 65 | 58 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Wuhan Taiyicheng Biopharmaceutical Co., Ltd. | 027-88320699 | tycshyy@126.com | China | 297 | 66 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Shanghai HuanChuan Industry Co.,Ltd. | 021-61478794 | sales@hcshhai.com | China | 9781 | 50 |
| Nanjing Chalf-Pharm Technology Co., Ltd. | 025-57018978 18251899859 | sales@chalf-pharm.com | China | 5855 | 50 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
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