EPIMESTROL
- CAS No.
- 7004-98-0
- Chemical Name:
- EPIMESTROL
- Synonyms
- Org 817;Stimovul;NSC 55975;EPIMESTROL;Estriol Impurity 11;3-Methoxy-17-epiestriol;3-Methoxyestra-1,3,5(10)-triene-16.α.,17.α.-diol;3-Methoxy)estra-1,3,5(10)-triene-16alpha,17alpha-diol;Estra-1,3,5(10)-triene-16,17-diol, 3-methoxy-, (16α,17α)-;(8R,9S,13S,14S,16R,17S)-3-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-16,17-diol
- CBNumber:
- CB5363814
- Molecular Formula:
- C19H26O3
- Molecular Weight:
- 302.41
- MDL Number:
- MFCD00198991
- MOL File:
- 7004-98-0.mol
| Melting point | 158-160° |
|---|---|
| alpha | D20 +48° (chloroform) |
| Boiling point | 450.8±45.0 °C(Predicted) |
| Density | 1.185±0.06 g/cm3(Predicted) |
| pka | 14.53±0.60(Predicted) |
| FDA UNII | 7IVE3SDZ38 |
| ATC code | G03GB03 |
EPIMESTROL Chemical Properties, Uses, Production
Originator
Stimovul,Organon,W. Germany,1976
Uses
Anterior pituitary activator.
Definition
ChEBI: Epimestrol is a steroid. It derives from a hydride of an estrane.
Manufacturing Process
Reduction of 16-keto-17(α)-hydroxyestratrienol-3-methyl to 16,17- dihydroxyestratrienol-3-methyl ether: A solution of 800 mg of the alpha ketol methyl ether in 100 cc of ethanol and 10 cc of acetic acid was carefully maintained at 40°C (water bath), and 200 g of freshly prepared sodium amalgam (2%) were added in small pieces with efficient swirling. Before all ofthe amalgam had been added, a precipitation of sodium acetate occurred, and at this point an additional 100 cc of 50% acetic acid were added. After all the reducing agent had been added, the mixture was transferred to a separatory funnel with ether and water. The mercury plus aqueous phase was separated, after partitioning, from the ether; the latter may be further washed with water, with 0.5N sodium hydroxide, and again with water to purify the alpha glycol. Evaporation of the ethereal phase yielded a crystalline residue of the isomeric transoid (16(β),17(α)-dihydroxy-steroid-3-methyl ether and cisoid 16(α),17(α)dihydroxy-steroid-3-methyl ether.
Therapeutic Function
Anterior pituitary activator
EPIMESTROL Preparation Products And Raw materials
EPIMESTROL Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Newmaterial Co., Ltd. | 029-63373950 17392216152 | 1035@dideu.com | China | 9991 | 58 |
| Hubei Qingbei Yunyan Pharmaceutical Technology Co., Ltd | 18162595016; 18162595016 | 3287908757@qq.com | China | 9111 | 58 |
| Hubei Rhema Reference Materials Technology Co., Ltd. | 15787879035 15787875101 | ydw9035@rmastandards.com | China | 9976 | 58 |
| TLC Pharmaceutical Standards Ltd. | 18012923235 | chinasales04@tlcstandards.com.cn | China | 8301 | 58 |
