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Ixazomib Impurity 1

CAS No.
1201903-02-7
Chemical Name:
Ixazomib Impurity 1
Synonyms
Ixazomib Impurity R;Ixazomib Impurity 1;Ixazomib Impurity N1;2,5-DiChloro-N-2-[[(1R)-1-[3aS,4S,5S,6aR)-hexahydro-3a,5,5-trimethyl-4,6-methane-1,3,2-benzodioxoborane-2-yl]ethylAmide;2,5-Dichloro-N-[2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]dec-4-yl]butyl}amino)-2-oxoethyl]benzamide;2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide;2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide;Benzamide, 2,5-dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-;2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide/ Ixazomib Impurity 1
CBNumber:
CB73054683
Molecular Formula:
C24H33BCl2N2O4
Molecular Weight:
495.25
MDL Number:
MOL File:
1201903-02-7.mol
Last updated:2025-07-04 15:33:40

Ixazomib Impurity 1 Properties

Boiling point 602.0±55.0 °C(Predicted)
Density 1.25±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility Dichloromethane; Chloroform; Methanol; Ethyl Acetate; DMSO;
form Solid
pka 12.10±0.46(Predicted)
color White
InChIKey CGUIBVMGUKXODV-OPKBTAHXSA-N
SMILES C(NCC(N[C@H](B1O[C@@]2(C)[C@@]3([H])C[C@@]([H])(C[C@@]2([H])O1)C3(C)C)CC(C)C)=O)(=O)C1=CC(Cl)=CC=C1Cl

Ixazomib Impurity 1 Chemical Properties, Uses, Production

Uses

2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide is an intermediate used in the synthesis of Ixazomib (I942000), which is a proteasome inhibitor that acts by preventing cell growth in solid tumours. It is an anticancer agent that is used to treat patients with multiple myeloma and is potentially neurotoxic.

Ixazomib Impurity 1 Preparation Products And Raw materials

Raw materials

Preparation Products

Ixazomib Impurity 1 Suppliers

Global Suppliers ( 32)
Supplier Tel Email Country ProdList Advantage
HANGZHOU YOUHELIN PHARMTECH CO.LTD 18268150871; 17302275155 tanglulu11129@163.com China 28 58
Hangzhou Hua Zhe Biological Medicine Co., LTD 0571-5683-8096 17302275155 tanglulu1129@163.com China 131 58
Chemipanda Bio-Tech Co., Ltd. +86-571-85224801; 13588483690 chemipanda2010@163.com China 98 62
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
Hunan Hezhong Pharmaceutical Co., Ltd. 027-87614241 3310618156 3310618156@qq.com China 62 50
Cangzhou Enke Pharma-tech Co., Ltd. 0317-5296180 15533709196 enkepharma@126.com China 2495 55
Jinan Yaoyan Pharmaceutical Co., Ltd. jnyaoyan@163.com China 3057 58
Alchemist-pharm chemical Technology Co. Ltd. 0371-67991738 13783628208 carl@alchemist-pharm.com China 1867 58
Shenzhen Botel Biotechnology Co. Ltd. 13316949107 13316968096 1979313431@qq.com China 9619 58
Ixazomib Impurity 1 2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide 2,5-Dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]-benzamide Benzamide, 2,5-dichloro-N-[2-[[(1R)-1-[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]-3-methylbutyl]amino]-2-oxoethyl]- Ixazomib Impurity R Ixazomib Impurity N1 2,5-Dichloro-N-[2-({(1R)-3-methyl-1-[(1S,2S,6R,8S)-2,9,9-trimethyl-3,5-dioxa-4-boratricyclo[6.1.1.02,6]dec-4-yl]butyl}amino)-2-oxoethyl]benzamide 2,5-dichloro-N-(2-(((R)-3-methyl-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)butyl)amino)-2-oxoethyl)benzamide/ Ixazomib Impurity 1 2,5-DiChloro-N-2-[[(1R)-1-[3aS,4S,5S,6aR)-hexahydro-3a,5,5-trimethyl-4,6-methane-1,3,2-benzodioxoborane-2-yl]ethylAmide 1201903-02-7 C24H33BCl2N2O4