COX-2 INHIBITOR I
- CAS No.
- 416901-58-1
- Chemical Name:
- COX-2 INHIBITOR I
- Synonyms
- LM-1685;COX-2 INHIBITOR I;METHYL [5-METHYLSULFONYL-1-(4-CHLOROBENZYL)-1H-2-INDOLYL]CARBOXYLATE;1H-Indole-2-carboxylic acid, 1-[(4-chlorophenyl)methyl]-5-(methylsulfonyl)-, methyl ester
- CBNumber:
- CB7306381
- Molecular Formula:
- C18H16ClNO4S
- Molecular Weight:
- 377.84
- MDL Number:
- MFCD04974157
- MOL File:
- Mol file
- MSDS File:
- SDS
COX-2 INHIBITOR I price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0066872 | COX-2-IN-5 | 416901-58-1 | 1mg | $619 | 2026-06-04 | Buy |
| aablocks | AA00C5NM | COX-2-IN-5 | 416901-58-1 | 1mg | $138 | 2026-05-28 | Buy |
| aablocks | AA00C5NM | COX-2-IN-5 | 416901-58-1 | 5mg | $299 | 2026-05-28 | Buy |
| aablocks | AA00C5NM | COX-2-IN-5 | 416901-58-1 | 10mg | $400 | 2026-05-28 | Buy |
| aablocks | AA00C5NM | COX-2-IN-5 | 416901-58-1 | 25mg | $554 | 2026-05-28 | Buy |
COX-2 INHIBITOR I Chemical Properties, Uses, Production
Uses
COX-2-IN-5 (compound 11a) is a potent COX-2 inhibitor with an IC50 value of 0.65 μM. COX-2-IN-5 has the potential for the research of inflammation[1].
Definition
ChEBI: LM-1685 is an indolyl carboxylate ester that is methyl 1H-indole-2-carboxylate substituted by a 4-chlorobenzyl group at position 1 and a methylsulfonyl group at position 5. It acts as a selective inhibitor of cyclooxygenase 2. It has a role as a cyclooxygenase 2 inhibitor. It is an indolyl carboxylate ester, a sulfone, a member of monochlorobenzenes and a methyl ester.
Biological Activity
Cell permeable: yes', 'Primary Target
COX-2 from human monocytes', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 650 nM against COX-2 from human monocytes; 4.3 μM against COX-2 in whole blood
IC 50
COX-2: 0.65 μM (IC50)
References
[1] Palomer A, et al. Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models. J Med Chem. 2002 Mar 28;45(7):1402-11. DOI:10.1021/jm010458r
COX-2 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
COX-2 INHIBITOR I Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
