FIT-039
- CAS No.
- 1113044-49-7
- Chemical Name:
- FIT-039
- Synonyms
- KP-1115;FIT-039;FIT-039 (FIT039);FIT-039, 10 mM in DMSO;N-[5-Fluoro-2-(1-piperidinyl)phenyl]-4-pyridinecarbothioamide;N-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridine-4-carbothioamide;4-Pyridinecarbothioamide, N-[5-fluoro-2-(1-piperidinyl)phenyl]-;Cytomegalovirus,HSV-1,Herpes simplex virus,transcription,Inhibitor,DNA,CDK,Cyclin dependent kinase,CDK9,CMV,FIT 039,mRNA,FIT039,viruses,antiviral,inhibit,orally,FIT-039,polymerase-II,HSV-2,DNA/RNA Synthesis,HSV
- CBNumber:
- CB73067546
- Molecular Formula:
- C17H18FN3S
- Molecular Weight:
- 315.41
- MDL Number:
- MFCD29770796
- MOL File:
- 1113044-49-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
FIT-039 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML2861 | FIT-039 ≥98% (HPLC) | 1113044-49-7 | 5 mg | $70.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML2861 | FIT-039 ≥98% (HPLC) | 1113044-49-7 | 25 mg | $288 | 2026-04-30 | Buy |
| Cayman Chemical | 36555 | FIT-039 ≥98% | 1113044-49-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 36555 | FIT-039 ≥98% | 1113044-49-7 | 5mg | $96 | 2026-04-30 | Buy |
| Cayman Chemical | 36555 | FIT-039 ≥98% | 1113044-49-7 | 10mg | $174 | 2026-04-30 | Buy |
FIT-039 Chemical Properties, Uses, Production
Description
FIT-039 is a novel cyclin-dependent kinase 9 (CDK9) inhibitor, suppressing replication of a broad spectrum of DNA viruses through inhibition of mRNA transcription.
Uses
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
in vivo
Treatment with the FIT-039 ointment twice a day suppresses skin lesions and rescues mice (male BALB/c mice injected with HSV-1) from lethality in a dose-dependent manner. The healing of lesions is observed with 5% to 10% FIT-039 ointment, leading to the complete regression of zosteriform spread on day 10, which is also observed with the 5% ACV ointment[1].
FIT-039 does not affect body weight gain in mice administrated with an overdose of this compound (1000 mg/kg/d) for 14 days, and no changes are observed in biological markers in their blood[1].
target
FIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV.
IC 50
CDK9/cyclinT1: 5.8 μM (IC50); HSV-1: 0.69 μM (IC50); HSV-2; CMV
References
[1] Makoto Yamamoto, et al. CDK9 Inhibitor FIT-039 Prevents Replication of Multiple DNA Viruses. J Clin Invest. 2014 Aug;124(8):3479-88. DOI:10.1172/JCI73805
FIT-039 Preparation Products And Raw materials
Raw materials
Preparation Products
FIT-039 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jiangsu Boquan Biotechnology Co., Ltd. | 19709916022 | 5954981@qq.com | China | 2458 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4859 | 55 | |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 989 | 55 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2969 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
