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BOC-L-Methionine

BOC-L-Methionine structure

CAS No.: 2488-15-5

Chemical Name:: BOC-L-Methionine

Synonyms: BOC-MET-OH;BOC-MET;BOC-L-MET;BOC-L-MET-OH;N-(TERT-BUTOXYCARBONYL)-L-METHIONINE;(S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid;Boc-Met-O;Boc-D-Met-OH;BOC-METHIONINE;BOC-L-METHIONINE

CBNumber:: CB7309504

Molecular Formula:: C10H19NO4S

Molecular Weight:: 249.33

MDL Number:: MFCD00065586

MOL File:: 2488-15-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:24:41

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BOC-L-Methionine Properties

Melting point	47-50 °C(lit.)
alpha	-23 º (c=1.3, methanol)
Boiling point	415.5±40.0 °C(Predicted)
Density	1.160±0.06 g/cm3(Predicted)
refractive index	-22 ° (C=1.3, AcOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	almost transparency in Methanol
form	Powder
pka	3.83±0.10(Predicted)
color	White to off-white
optical activity	[α]20/D 22°, c = 1 in methanol
BRN	1727869
Major Application	peptide synthesis
InChI	1S/C10H19NO4S/c1-10(2,3)15-9(14)11-7(8(12)13)5-6-16-4/h7H,5-6H2,1-4H3,(H,11,14)(H,12,13)/t7-/m0/s1
InChIKey	IMUSLIHRIYOHEV-ZETCQYMHSA-N
SMILES	CSCC[C@H](NC(=O)OC(C)(C)C)C(O)=O
CAS DataBase Reference	2488-15-5(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335

Precautionary statements

P280-P304+P340-P312

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

9-23

HS Code

2930 90 98

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

BOC-L-Methionine price More Price(83)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	408425	Boc-Met-OH 99%	2488-15-5	5g	$62.6	2026-04-30	Buy
Sigma-Aldrich	8.53054	Boc-Met-OH Novabiochem?	2488-15-5	25g	$111	2026-04-30	Buy
Sigma-Aldrich	408425	Boc-Met-OH 99%	2488-15-5	25g	$116	2026-04-30	Buy
Sigma-Aldrich	8.53054	Boc-Met-OH Novabiochem?	2488-15-5	100g	$395	2025-07-31	Buy
TCI Chemical	B1636	N-(tert-Butoxycarbonyl)-L-methionine >98.0%(HPLC)(T)	2488-15-5	10g	$97	2026-04-30	Buy

Product number	Packaging	Price	Buy
408425	5g	$62.6	Buy
8.53054	25g	$111	Buy
408425	25g	$116	Buy
8.53054	100g	$395	Buy
B1636	10g	$97	Buy

BOC-L-Methionine Chemical Properties, Uses, Production

Chemical Properties

white to off-white microcrystalline powder

Uses

N-Boc-L-methionine is an N-Boc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

63-68-3

24424-99-5

2488-15-5

Example 1 [0041] 7.2 g of L-methionine was dissolved in a solvent mixture of 50 mL of water and 50 mL of acetonitrile. To this solution was added 2 g of sodium hydroxide (0.05 mol). The reaction mixture was cooled to 0 °C, followed by the slow addition of 10.9 g of di-tert-butyl dicarbonate (0.05 mol). After addition, the reaction system was gradually warmed to room temperature (24-25 °C) and the reaction was continuously stirred for 12 hours. After completion of the reaction, the acetonitrile was removed by rotary evaporation. To the residual aqueous phase, potassium carbonate was added and the pH was adjusted to 12. The aqueous phase was extracted twice with 50 mL of dichloromethane and the organic phase was discarded. To the aqueous phase, 1 N hydrochloric acid was added dropwise and the pH was adjusted to 6. The aqueous phase was again extracted twice with 50 mL of dichloromethane, the organic phases were combined, washed with 50 mL of saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give viscous Boc-L-methionine (11.4 g) in 95% yield. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 11.62 (br, 1H), 6.91 (br, 1H), 4.40 (m, 1H), 2.52 (t, J = 4.8 Hz, 2H), 2.05 (s, 3H), 1.92-2.15 (m, 2H), 1.42 (s, 9H). Mass spectrometry (MS) showed a molecular ion peak (M + 1) of 250.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Tetrahedron Letters, 1994, vol. 35, # 14, p. 2121 - 2124
[3] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0040; 0041
[4] Organic Syntheses, 1985, vol. 63, p. 160 - 160
[5] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-L-Methionine synthesis

Synthesis of BOC-L-Methionine from L-Methionine and Di-tert-butyl dicarbonate

BOC-L-Methionine Preparation Products And Raw materials

Raw materials

tert-Butyl 2,3-dihydro-2-oxo-3-oxazolecarboxylate Boc-Met-OH dcha N-Boc-Benzotriazole tert-Butyl 1,2,2,2-tetrachloroethyl carbonate) Acetonitrile

FMOC-L-Methionine Di-tert-butyl dicarbonate Carbonic acid, bis(1,1-dimethylethyl) ester tert-butyl azidoformate L-Methionine

1of2

Preparation Products

2-Pyridinethione Boc-Met-ONp 2-Hydroxypyridine Boc-Met-ol H-Met-Gly-OH

BOC-L-Methionine Suppliers

Global Suppliers ( 329)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	+86-21-54098501	sales@sinch.com.cn	China	11592	64
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
GL Biochem (Shanghai) Ltd	64
Capot Chemical Co., Ltd	66
Shanghai Sinch Parmaceuticals Tech. Co. Ltd.	64
Jia Xing Isenchem Co.,Ltd	66

View Latest Price from BOC-L-Methionine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	Boc-Met-OH 2488-15-5		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2026-09-02	BOC-L-Methionine 2488-15-5	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
2019-07-06	BOC-L-Methionine 2488-15-5	$1.00	1KG	99%	20kg	Career Henan Chemical Co

Boc-Met-OH
2488-15-5
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-L-Methionine
2488-15-5
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

BOC-L-Methionine
2488-15-5
$1.00
99%
Career Henan Chemical Co

BOC-L-Methionine Spectrum

BOC-L-Methionine(2488-15-5)MS BOC-L-Methionine(2488-15-5)¹HNMR BOC-L-Methionine(2488-15-5)¹³CNMR BOC-L-Methionine(2488-15-5)IR1 BOC-L-Methionine(2488-15-5)IR2

2488-15-5 (BOC-L-Methionine) Related Search:

1,1'-Carbonyldiimidazole Zinc methionine sulfate N-Carbobenzyloxyglycine L-Methionine DL-Methionine

L-Selenomethionine tert-Butyl carbazate S-(5'-Adenosyl)-L-methionine p-toluenesulfonate salt Di-tert-butyl ether Carbonyl iron powder

N-BOC-D-METHIONINE,N-Boc-D-methionine, 98+%,N-ALPHA-T-BOC-D-METHIONINE,BOC-D-METHIONINE Boc-Met(o)-OH Boc-Met-OSu 4-N-Boc-amino-4-carboxytetrahydrothiopyran Boc-Met-OH dcha

Boc-Met-ONp Boc-L-Met-O-CH2-phi-CH2-COOH Boc-2-amino-4-(ethyl(thio))butyric acid

1of4

L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]- N-(tert-Butoxycarbonyl)-L-methionine ,98% (S)-2-[(tert-Butyloxycarbonyl)amino]-4-(methylthio)butyric acid Boc-L-methionine ,98% Boc-Met-O N-Boc-L-methionine Boc-Met-OH 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid N-(tert-Butoxycarbonyl)-L-methionine, Boc-L-methionine BOC-L-METHIONINE-OH BOC-L-METHIONINE BOC-METHIONINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-METHIONINE N-ALPHA-T-BUTOXYCARBONYL-L-METHIONINE N-ALPHA-T-BOC-L-METHIONINE N-BOC-L-METHIONINE N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-METHIONINE TBOC-L-METHIONINE (Tert-Butoxy)Carbonyl Met-OH (Solid) (Tert-Butoxy)Carbonyl Met-OH (Syrup) N-T-BOC-L-METHIONINE (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid L--Methionine, N-BOC protected (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid (2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate Boc-L-methionine - Solid N-(tert-Butoxycarbonyl)-L-Methionine, 98.0%(LC&T Boc-Met-OH (Solid) Boc-Met-OH (Oil) Boc-L-methionine≥ 99% (HPLC) T-BUTYLOXYCARBONYL-L-METHIONINE tert-butoxycarbonyl-L-methionine N-T-BOC-L-METHIONINE FREE ACIDCRYSTALLIN E N-(TERT-BUTOXYCARBONYL)-L-METHIONINE, 99 % BOC-L-Methionine, 99+% N-ALPHA-T-BUTYLOXYCARBONYL-L-METHIONINE BOC-L-METHIONENE BOC-L-METHIONENE FREE ACID BOC-L-METHIONENE FREE BASE Boc-D-Met-OH N-Boc-L-methionine, 98+% N-(tert-Butoxycarbonyl)-L-methionine > (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoicaci BOC-L-Methionine USP/EP/BP BOC-L-Methionine extrapure, 98.5% (S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid BOC-L-MET-OH BOC-L-MET BOC-MET-OH BOC-MET N-(TERT-BUTOXYCARBONYL)-L-METHIONINE 2488-15-5 C10H19NO4S CH3SCH2CH2CHCOOHNHCOOCCH33 Amino Acid Derivatives Amino Acids (N-Protected) Boc-Amino Acids Protected & Labeled Amino Acids Peptide Synthesis