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BOC-L-Methionine

BOC-L-Methionine structure

CAS No.: 2488-15-5

Chemical Name:: BOC-L-Methionine

Synonyms: BOC-MET;Boc-Met-O;BOC-L-MET;BOC-MET-OH;BOC-L-MET-OH;Boc-D-Met-OH;BOC-METHIONINE;BOC-L-METHIONINE;Boc-Met-OH (Oil);BOC-L-METHIONENE

CBNumber:: CB7309504

Molecular Formula:: C10H19NO4S

Molecular Weight:: 249.33

MDL Number:: MFCD00065586

MOL File:: 2488-15-5.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:47

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BOC-L-Methionine Properties

Melting point	47-50 °C(lit.)
alpha	-23 º (c=1.3, methanol)
Boiling point	415.5±40.0 °C(Predicted)
Density	1.160±0.06 g/cm3(Predicted)
refractive index	-22 ° (C=1.3, AcOH)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	almost transparency in Methanol
form	Powder
pka	3.83±0.10(Predicted)
color	White to off-white
optical activity	[α]20/D 22°, c = 1 in methanol
BRN	1727869
CAS DataBase Reference	2488-15-5(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H335

Precautionary statements

P280-P304+P340-P312

Hazard Codes

Risk Statements

20/21/22-36/37/38

Safety Statements

24/25-36-26

WGK Germany

9-23

HS Code

2930 90 98

NFPA 704

	1
0		0

BOC-L-Methionine price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.53054	Boc-Met-OH Novabiochem?	2488-15-5	25g	$104	2025-07-31	Buy
Sigma-Aldrich	8.53054	Boc-Met-OH Novabiochem?	2488-15-5	100g	$395	2025-07-31	Buy
Sigma-Aldrich	408425	Boc-Met-OH 99%	2488-15-5	5g	$58.8	2025-07-31	Buy
Sigma-Aldrich	408425	Boc-Met-OH 99%	2488-15-5	25g	$109	2025-07-31	Buy
TCI Chemical	B1636	N-(tert-Butoxycarbonyl)-L-methionine >98.0%(HPLC)(T)	2488-15-5	10g	$64	2025-07-31	Buy

Product number	Packaging	Price	Buy
8.53054	25g	$104	Buy
8.53054	100g	$395	Buy
408425	5g	$58.8	Buy
408425	25g	$109	Buy
B1636	10g	$64	Buy

BOC-L-Methionine Chemical Properties,Uses,Production

Chemical Properties

white to off-white microcrystalline powder

Uses

N-Boc-L-methionine is an N-Boc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Boc solid-phase peptide synthesis

Synthesis

63-68-3

24424-99-5

2488-15-5

Example 1 [0041] 7.2 g of L-methionine was dissolved in a solvent mixture of 50 mL of water and 50 mL of acetonitrile. To this solution was added 2 g of sodium hydroxide (0.05 mol). The reaction mixture was cooled to 0 °C, followed by the slow addition of 10.9 g of di-tert-butyl dicarbonate (0.05 mol). After addition, the reaction system was gradually warmed to room temperature (24-25 °C) and the reaction was continuously stirred for 12 hours. After completion of the reaction, the acetonitrile was removed by rotary evaporation. To the residual aqueous phase, potassium carbonate was added and the pH was adjusted to 12. The aqueous phase was extracted twice with 50 mL of dichloromethane and the organic phase was discarded. To the aqueous phase, 1 N hydrochloric acid was added dropwise and the pH was adjusted to 6. The aqueous phase was again extracted twice with 50 mL of dichloromethane, the organic phases were combined, washed with 50 mL of saturated sodium chloride solution, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to give viscous Boc-L-methionine (11.4 g) in 95% yield. The product was characterized by 1H NMR (500 MHz, CDCl3): δ 11.62 (br, 1H), 6.91 (br, 1H), 4.40 (m, 1H), 2.52 (t, J = 4.8 Hz, 2H), 2.05 (s, 3H), 1.92-2.15 (m, 2H), 1.42 (s, 9H). Mass spectrometry (MS) showed a molecular ion peak (M + 1) of 250.

References

[1] Antimicrobial Agents and Chemotherapy, 2017, vol. 61, # 3,
[2] Tetrahedron Letters, 1994, vol. 35, # 14, p. 2121 - 2124
[3] Patent: EP2647624, 2013, A1. Location in patent: Paragraph 0040; 0041
[4] Organic Syntheses, 1985, vol. 63, p. 160 - 160
[5] Tetrahedron Letters, 2018, p. 4267 - 4271

BOC-L-Methionine synthesis

Synthesis of BOC-L-Methionine from L-Methionine and Di-tert-butyl dicarbonate

BOC-L-Methionine Preparation Products And Raw materials

Raw materials

TERT-BUTYL 2,3-DIHYDRO-2-OXO-3-OXAZOLECARBOXYLATE BOC-MET-OH DCHA N-Boc-Benzotriazole TERT-BUTYL 1,2,2,2-TETRACHLOROETHYL CARBONATE) Acetonitrile

FMOC-L-Methionine Di-tert-butyl dicarbonate Carbonic acid, bis(1,1-dimethylethyl) ester tert-butyl azidoformate L-Methionine

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Preparation Products

2-Pyridinethione BOC-MET-ONP 2-Hydroxypyridine BOC-MET-OL H-MET-GLY-OH

BOC-L-Methionine Suppliers

Global( 332)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	+8617390183901	cynthia@enlaibio.com	China	1100	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20188	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29734	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29854	58
Xiamen AmoyChem Co., Ltd	+86-86-5926051114 +8615060885618	sales@amoychem.com	China	6369	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49975	58

Supplier	Advantage
Sichuan HongRi Pharma-Tech Co.,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Xiamen AmoyChem Co., Ltd	58
Hubei xin bonus chemical co. LTD	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from BOC-L-Methionine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-09-24	Boc-Met-OH 2488-15-5	US $0.00-0.00 / kg	1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd
2023-12-24	BOC-L-Methionine 2488-15-5	US $100.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2019-07-06	BOC-L-Methionine 2488-15-5	US $1.00 / KG	1KG	99%	20kg	Career Henan Chemical Co

Boc-Met-OH
2488-15-5
US $0.00-0.00 / kg
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

BOC-L-Methionine
2488-15-5
US $100.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

BOC-L-Methionine
2488-15-5
US $1.00 / KG
99%
Career Henan Chemical Co

BOC-L-Methionine Spectrum

BOC-L-Methionine(2488-15-5)MS BOC-L-Methionine(2488-15-5)¹HNMR BOC-L-Methionine(2488-15-5)¹³CNMR BOC-L-Methionine(2488-15-5)IR1 BOC-L-Methionine(2488-15-5)IR2

2488-15-5(BOC-L-Methionine)Related Search:

tert-Butyl carbazate N-Carbobenzyloxyglycine Zinc methionine sulfate 1,1'-Carbonyldiimidazole L-Selenomethionine

S-ADENOSYL-L-METHIONINE DL-Methionine L-Methionine DI-TERT-BUTYL ETHER 4-N-BOC-AMINO-4-CARBOXYTETRAHYDROTHIOPYRAN

BOC-L-METHIONINE (O),BOC-L-METHIONINE SULFOXIDE,N-ALPHA-T-BOC-L-METHIONINE-D,L-SULFOXIDE BOC-MET-OSU N-alpha-t-boc-L-methionine(dicyclohexylammoniumsaltcrystalline),Boc-L-Methionine·DCHA,Boc-L-methionine dicyclohexylamine salt Carbonyl iron powder N-BOC-D-METHIONINE,N-Boc-D-methionine, 98+%,N-ALPHA-T-BOC-D-METHIONINE,BOC-D-METHIONINE

BOC-2-AMINO-4-(ETHYL(THIO))BUTYRIC ACID BOC-L-MET-O-CH2-PHI-CH2-COOH BOC-L-METHIONINE P-NITROPHENYL ESTER,BOC-L-METHIONINE 4-NITROPHENYL ESTER

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L-Methionine, N-[(1,1-dimethylethoxy)carbonyl]- N-(tert-Butoxycarbonyl)-L-methionine ,98% (S)-2-[(tert-Butyloxycarbonyl)amino]-4-(methylthio)butyric acid Boc-L-methionine ,98% Boc-Met-O N-Boc-L-methionine Boc-Met-OH (S)-2-((tert-butoxycarbonyl)aMino)-4-(Methylthio)butanoic acid 2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid N-(tert-Butoxycarbonyl)-L-methionine, Boc-L-methionine BOC-L-MET-OH BOC-L-METHIONINE-OH BOC-L-MET BOC-L-METHIONINE BOC-MET-OH BOC-MET BOC-METHIONINE N-ALPHA-TERT-BUTYLOXYCARBONYL-L-METHIONINE N-ALPHA-T-BUTOXYCARBONYL-L-METHIONINE N-ALPHA-T-BOC-L-METHIONINE N-BOC-L-METHIONINE N-[(1,1-DIMETHYLETHOXY)CARBONYL]-L-METHIONINE TBOC-L-METHIONINE (Tert-Butoxy)Carbonyl Met-OH (Solid) (Tert-Butoxy)Carbonyl Met-OH (Syrup) N-(TERT-BUTOXYCARBONYL)-L-METHIONINE N-T-BOC-L-METHIONINE (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoic acid L--Methionine, N-BOC protected (2S)-2-{[(tert-butoxy)carbonyl]amino}-4-(methylsulfanyl)butanoic acid (2S)-2-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-4-(methylthio)butanoate Boc-L-methionine - Solid N-(tert-Butoxycarbonyl)-L-Methionine, 98.0%(LC&T Boc-Met-OH (Solid) Boc-Met-OH (Oil) Boc-L-methionine≥ 99% (HPLC) T-BUTYLOXYCARBONYL-L-METHIONINE tert-butoxycarbonyl-L-methionine N-T-BOC-L-METHIONINE FREE ACIDCRYSTALLIN E N-(TERT-BUTOXYCARBONYL)-L-METHIONINE, 99 % BOC-L-Methionine, 99+% N-ALPHA-T-BUTYLOXYCARBONYL-L-METHIONINE BOC-L-METHIONENE BOC-L-METHIONENE FREE ACID BOC-L-METHIONENE FREE BASE Boc-D-Met-OH N-Boc-L-methionine, 98+% N-(tert-Butoxycarbonyl)-L-methionine > (2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-methylsulfanylbutanoicaci BOC-L-Methionine USP/EP/BP BOC-L-Methionine extrapure, 98.5% 2488-15-5 C10H19NO4S CH3SCH2CH2CHCOOHNHCOOCCH33 Amino Acid Derivatives Amino Acids (N-Protected) Boc-Amino Acids Protected & Labeled Amino Acids Peptide Synthesis