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FMOC-L-Methionine

FMOC-L-Methionine structure

CAS No.: 71989-28-1

Chemical Name:: FMOC-L-Methionine

Synonyms: Fmoc-Met-OH;FMOC-MET;FMOC-L-MET-OH;FMOC-L-MET;FMOC-METHIONINE;(S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(Methylthio)butanoic acid;N-Fmoc-L;N-FMOC-L-MET;N-FMOC-MET-OH;N-Fmoc-L-Met-OH

CBNumber:: CB3304389

Molecular Formula:: C20H21NO4S

Molecular Weight:: 371.45

MDL Number:: MFCD00037134

MOL File:: 71989-28-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 01:43:08

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FMOC-L-Methionine Properties

Melting point	121-123 °C(lit.)
alpha	-29 º (c=1,DMF 24 ºC)
Boiling point	614.6±55.0 °C(Predicted)
Density	1.2053 (rough estimate)
refractive index	-29.5 ° (C=1, DMF)
storage temp.	2-8°C
solubility	very faint turbidity in Methanol
pka	3.72±0.10(Predicted)
form	Granular Powder
color	White
optical activity	[α]20/D -29.5±1.5°, c = 1% in DMF
BRN	4300266
Major Application	peptide synthesis
InChI	InChI=1S/C20H21NO4S/c1-26-11-10-18(19(22)23)21-20(24)25-12-17-15-8-4-2-6-13(15)14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3,(H,21,24)(H,22,23)/t18-/m0/s1
InChIKey	BUBGAUHBELNDEW-SFHVURJKSA-N
SMILES	C(O)(=O)[C@H](CCSC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	71989-28-1(CAS DataBase Reference)
UNSPSC Code	12352209
NACRES	NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P305+P351+P338

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

22-24/25-36/37/39-27-26

WGK Germany

HS Code

2930 90 98

Storage Class

11 - Combustible Solids

NFPA 704

	1
0		0

FMOC-L-Methionine price More Price(91)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.52002	Fmoc-Met-OH Novabiochem?	71989-28-1	25g	$33.8	2026-04-30	Buy
Sigma-Aldrich	8.52002	Fmoc-Met-OH Novabiochem?	71989-28-1	100g	$83	2026-04-30	Buy
Sigma-Aldrich	8.52002	Fmoc-Met-OH Novabiochem?	71989-28-1	250g	$179	2026-04-30	Buy
Sigma-Aldrich	8.52002	Fmoc-Met-OH Novabiochem^®	71989-28-1	500 g	$328	2026-04-30	Buy
Sigma-Aldrich	8.52002	Fmoc-Met-OH Novabiochem?	71989-28-1	1kg	$588	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.52002	25g	$33.8	Buy
8.52002	100g	$83	Buy
8.52002	250g	$179	Buy
8.52002	500 g	$328	Buy
8.52002	1kg	$588	Buy

FMOC-L-Methionine Chemical Properties, Uses, Production

Chemical Properties

white to light yellow crystal powde

Uses

N-Fmoc-L-methionine is an N-Fmoc-protected form of L-Methionine (M260440). L-Methionine is an essential amino acid that is obtained from our diet. L-Methionine can be found in grain legumes (such as lentils), and poultry. L-Methionine’s main function is to act as the primary “Start” sequence on mRNA so that the ribosomes can start translating the mRNA into proteins.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

63-68-3

N-(9-Fluorenylmethoxycarbonyloxy)succinimide

82911-69-1

71989-28-1

Synthesis of Fmoc-L-methionine: 6 mmol of L-methionine and 6.3 mmol of 9-fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu) were dissolved in 20 mL of N,N-dimethylformamide (DMF). Subsequently, 6.3 mmol of sodium bicarbonate (NaHCO3) was added to the reaction mixture to neutralize the acid produced during the reaction and to remove the solvent and residual amines. The reaction mixture was stirred at 50 °C overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified to afford the target compound Fmoc-L-methionine in 78% yield.

References

[1] Patent: CN105622471, 2016, A. Location in patent: Paragraph 0019; 0020
[2] Synthetic Communications, 2009, vol. 39, # 11, p. 2022 - 2031
[3] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 13, p. 2980 - 2983

FMOC-L-Methionine synthesis

Synthesis of FMOC-L-Methionine from L-Methionine and Fmoc-OSu

FMOC-L-Methionine Preparation Products And Raw materials

Raw materials

1H-Benzotriazole-1-carboxylic acid, 9H-fluoren-9-ylmethyl ester methyl (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoate FMoc-DL-Methionine 9-Fluorenylmethyl pentafluorophenyl carbonate Sodium bicarbonate

Fmoc-OSu 9-Fluorenylmethyl chloroformate N,N-Dimethylformamide L-Methionine

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Preparation Products

BOC-L-Methionine H-Met-NH2

FMOC-L-Methionine Suppliers

Global Suppliers ( 512)

Supplier	Tel	Email	Country	ProdList	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	0519-85720003 18861157602	410649415@qq.com	China	111	58
Chengdu ZY Biochemical Technology Co., Ltd.	88680086 13398185735	fengzilong@zybiochem.com	China	177	58
Wuhan Grand Hoyo Co., Ltd.	15377006636	670196467@qq.com	China	31	58
Shanxi Nuocheng Biotechnology Co., Ltd	17835231871	572710841@qq.com	China	7939	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Chengdu ZY Biochemical Technology Co., Ltd.	58
Wuhan Grand Hoyo Co., Ltd.	58
Shanxi Nuocheng Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Latest Price from FMOC-L-Methionine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-17	Fmoc-L-Methionine 71989-28-1	$5.00	1kg	≥99%	100mt/year	Jinan Finer Chemical Co., Ltd
2026-09-17	FMOC-L-Methionine 71989-28-1		1kg	98%min	100kg	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-17	Fmoc-L-Met-OH 71989-28-1		1kg	98%	1T	Sichuan HongRi Pharma-Tech Co.,Ltd

Fmoc-L-Methionine
71989-28-1
$5.00
≥99%
Jinan Finer Chemical Co., Ltd

FMOC-L-Methionine
71989-28-1
$0.00
98%min
WUHAN FORTUNA CHEMICAL CO., LTD

Fmoc-L-Met-OH
71989-28-1
98%
Sichuan HongRi Pharma-Tech Co.,Ltd

FMOC-L-Methionine Spectrum

FMOC-L-Methionine(71989-28-1)MS FMOC-L-Methionine(71989-28-1)¹HNMR FMOC-L-Methionine(71989-28-1)¹³CNMR FMOC-L-Methionine(71989-28-1)IR1 FMOC-L-Methionine(71989-28-1)IR2

71989-28-1 (FMOC-L-Methionine) Related Search:

Fmoc-Asp(OtBu)-OH 9-Fluorenylmethyl chloroformate 1,1'-Carbonyldiimidazole DL-Methionine L-Fmoc-Aspartic acid alpha-tert-butyl ester

Fmoc-Lys(Boc)-OH L-Methionine Fmoc-Phe-OH Zinc methionine sulfate Fmoc-Aib-OH

Fmoc-Pro-OH Fmoc-OSu Carbonyl sulfide Fmoc-L-glutamic acid FMOC-L-Valine

Fmoc-L-glutamic acid-gamma-benzyl ester Fmoc-L-hydroxyproline Fmoc-Chg-OH

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FMOC-L-METHIONINE N-ALPHA-FMOC-L-METHIONINE N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE N-[(9H-FLUOREN-9-YLMETHOXY)CARBONYL]-L-METHIONINE N-9-FLUORENYLMETHYLOXYCARBONYL-L-METHIONINE N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-L-METHIONINE N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE N-FLUORENYLMETHOXYCARBONYL-L-METHIONINE N-FMOC-MET-OH N-FMOC-L-MET N-FMOC-L-METHIONINE N-Fmoc-L-methionine Fmoc-Met-OH L-METHIONINE-N-FMOC (1-13C) L-METHIONINE-N-FMOC (13C5,15N) L-METHIONINE-N-FMOC (15N) L-METHIONINE-N-FMOC (METHYL-13C) Fmoc-Met-OH >=98.0% (HPLC) Fmoc-L-methionine≥ 99% (HPLC) (9H-Fluoren-9-yl)MethOxy]Carbonyl Met-OH (2S)-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-4-(methylsulfanyl)butanoic acid 9-FLUORENYLMETHOXYCARBONYL-L-METHIONINE FMOC-L-METHIONINE 98% L-Methionine-N-FMOC-UL-13C5, 15N N-(9-FLUORENYLMETHOXYCARBONYL)-L-METHIONINE(FMOC-L-MET-OH) L-Methionine/DL-Methionine FMOC-L-METHIONINE extrapure 2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methylsulfanylbutanoic acid L-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]- N-(9-Fluorenylmethoxycarbonyl)-L-methionine ,98% Fmoc-S-Methyl-Hcy-OH N-(9H-Fluorene-9-ylmethoxycarbonyl)-S-methyl-L-homocysteine N-Fmoc-L-Met-OH N-Fmoc-L-methionine, 98+% FMOC-L-Methionine,98% N-[(9H-Fluoren-9-ylmethoxycarbonyl]-L-Methionine(Fmoc-L-Met-OH) Fmoc-Methionine-OH N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-methionine> FMOC-MET-OH 100 G FMOC-MET-OH 25 G FMOC-MET-OH 250 G N-Fmoc-L FMOC-L-Methionine USP/EP/BP N-Fmoc-L-Methionine-34S N-(9-Fluorenyl methoxy carbonyl)methionine FMOC-METHIONINE (S)-2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-4-(Methylthio)butanoic acid FMOC-L-MET FMOC-L-MET-OH FMOC-MET Fmoc-Met-OH 71989-28-1 71898-28-1 CH3SCH2CH2CHNHFMOCCOOH C20H20NO4S Amino Acid Derivatives Fmoc-Amino Acids Amino Acids (N-Protected) Protected & Labeled Amino Acids