- Danirixin
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- $56.00
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2026-07-27
- CAS:954126-98-8
- Purity: 99.78%
- Supply Ability: 10g
- Danirixin
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- $1.00
-
2019-12-26
- CAS:954126-98-8
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | Danirixin Basic information |
| Product Name: | Danirixin | | Synonyms: | Danirixin;Danirixin (GSK1325756);Solabegron Hydrochloride;Danirixin HCl;1-[4-Chloro-2-hydroxy-3-(piperidine-3-sulfonyl)-phenyl]-3-(3-fluoro-2-methyl-phenyl)-urea;CS-2750;CS-1940;N-{4-chloro-2-hydroxy-3-[(3S)-3-piperidinylsulfonyl]phenyl}-N'-(3-fluoro-2-methylphenyl)urea | | CAS: | 954126-98-8 | | MF: | C19H21ClFN3O4S | | MW: | 441.91 | | EINECS: | | | Product Categories: | | | Mol File: | 954126-98-8.mol |  |
| | Danirixin Chemical Properties |
| Melting point | >153°C (dec.) | | Boiling point | 533.1±50.0 °C(Predicted) | | density | 1.467±0.06 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Methanol (Slightly) | | pka | 4.95±0.10(Predicted) | | form | Solid | | color | White to Light Brown | | InChIKey | NGYNBSHYFOFVLS-LBPRGKRZSA-N | | SMILES | O=C(NC1=CC=C(C(S([C@H]2CCCNC2)(=O)=O)=C1O)Cl)NC3=C(C(F)=CC=C3)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Danirixin Usage And Synthesis |
| Uses | Antidiabetic (β3 adrenoreceptor agonist). | | Biological Activity | Danirixin (GSK1325756) is an orally active, selective CXC chemokine receptor 2 (CXCR2) antagonist with 78-fold lower affinity toward CXCR1 (CXCR2/CXCR1 IC50 = 12.5/977 nM by competitive binding against 0.225 nM [125I] CXCL8). Danirixin blocks agonist-induced neutrophil CD11b expression in vitro (IC50 = 420/890 nM against induction by 10 nM human CXCL1/r at CXCL2 using rat/human whole blood) and prevents lung neutrophils influx in rats in vivo following aerosol lipopolysaccharide or ozone challenge (ED50 = 1.4 and 16 mg/kg, respectively). | | IC 50 | CXCL8-CXCR2: 12.5 nM (IC50) |
| | Danirixin Preparation Products And Raw materials |
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