Acid Ceramidase Inhibitor 17a
- CAS No.
- 1644158-57-5
- Chemical Name:
- Acid Ceramidase Inhibitor 17a
- Synonyms
- ARN14974;ARN14974, 10 mM in DMSO;Acid Ceramidase Inhibitor 17a;Acid Ceramidase Inhibitor IV, BOC;3(2H)-Benzoxazolecarboxamide, 6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-;6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)benzo[d]oxazole-3(2H)-carboxamide;6-(4-Fluorophenyl)-2-oxo-N-(4-phenylbutyl)-1,3-benzoxazole-3(2H)-carboxamide;6-(4-fluorophenyl)-2-oxo-N-(4-phenylbutyl)-2,3-dihydro-1,3-benzoxazole-3-carboxamide;benzoxazolone,signaling,Inhibitor,inhibit,Ceramidase,ARN 14974,ceramide-mediated,carboxamide,ARN14974,sphingosine,ARN-14974,dysfunctional
- CBNumber:
- CB73124052
- Molecular Formula:
- C24H21FN2O3
- Molecular Weight:
- 404.434
- MDL Number:
- MFCD32196894
- MOL File:
- 1644158-57-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Acid Ceramidase Inhibitor IV, BOC | 5.33371 | 10 mg | $219 |
| ARN14974 ≥95% | 17119 | 1mg | $30 |
| ARN14974 ≥95% | 17119 | 5mg | $135 |
| ARN14974 ≥95% | 17119 | 10mg | $208 |
| ARN14974 ≥95% | 17119 | 25mg | $483 |
| More product size | |||
Acid Ceramidase Inhibitor 17a price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.33371 | Acid Ceramidase Inhibitor IV, BOC | 1644158-57-5 | 10 mg | $219 | 2026-04-30 | Buy |
| Cayman Chemical | 17119 | ARN14974 ≥95% | 1644158-57-5 | 1mg | $30 | 2026-04-30 | Buy |
| Cayman Chemical | 17119 | ARN14974 ≥95% | 1644158-57-5 | 5mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 17119 | ARN14974 ≥95% | 1644158-57-5 | 10mg | $208 | 2026-04-30 | Buy |
| Cayman Chemical | 17119 | ARN14974 ≥95% | 1644158-57-5 | 25mg | $483 | 2026-04-30 | Buy |
Acid Ceramidase Inhibitor 17a Chemical Properties,Uses,Production
Uses
Acid Ceramidase Inhibitor 17a is a benzoxazolone carboxamide that potently inhibits acid cerimidase.
Biological Activity
Cell permeable: yes', 'Primary Target
Acid ceramidase', 'Reversible: no', 'Target IC50: 79 nM against HEK293 lysosomal lysate AC activity
in vivo
ARN14974 (10 mg/kg; i.p.; mice) causes a substantial reduction in AC activity in multiple organs, including brain, liver, heart, lungs, and kidney[1].
ARN14974 (10 mg/kg; i.p.) quickly enters the bloodstream after a single intraperitoneal administration in mice, reaching a maximal plasma concentration, Cmax, of 1767.9 ng/mL and displaying a half-life time of 458 min in circulation. ARN14974 (1 mg/kg; i.v.) shows a Cmax and a half-life time of 628 ng/mL and 72 min, respectively[1].
Acid Ceramidase Inhibitor 17a Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4876 | 55 | |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 3000 | 55 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
