7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
- CAS No.
- 75450-34-9
- Chemical Name:
- 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one
- Synonyms
- CGP;CGP 37157;CGP-37157 ，E0002;CGP37157, 10 mM in DMSO;1-benzothiazepine-2(3H)-one;7-Chloro-5-(2-chlorophenyl)-1;CGP 37157, Na+-Ca2+ exchange inhibitor;CGP-37157 - CAS 75450-34-9 - Calbiochem;7-chloro-5-(2-chlorophenyl)benzo[e][1,4]thiazepin-2(1H,3H,5H)-one;CGP 37157,CGP37157,Inhibitor,CGP-37157,inhibit,Na+/Ca2+ Exchanger
- CBNumber:
- CB7314153
- Molecular Formula:
- C15H11Cl2NOS
- Molecular Weight:
- 324.22
- MDL Number:
- MFCD09055422
- MOL File:
- 75450-34-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 479.8±45.0 °C(Predicted) |
|---|---|
| Density | 1.384±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: ≥20mg/mL |
| pka | 12.20±0.40(Predicted) |
| form | White solid |
| color | white |
| Stability | Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months. |
| InChI | 1S/C15H11Cl2NOS/c16-9-5-6-13-11(7-9)15(20-8-14(19)18-13)10-3-1-2-4-12(10)17/h1-7,15H,8H2,(H,18,19) |
| InChIKey | KQEPIRKXSUIUTH-UHFFFAOYSA-N |
| SMILES | Clc1ccc2NC(=O)CSC(c3ccccc3Cl)c2c1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H400-H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P330-P501-P273-P391-P501 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C8874 | CGP-37157 ≥98% (HPLC), powder | 75450-34-9 | 5mg | $184 | 2026-04-30 | Buy |
| Sigma-Aldrich | 220005 | CGP-37157 | 75450-34-9 | 5mg | $230 | 2024-03-01 | Buy |
| TCI Chemical | C3956 | CGP 37157 | 75450-34-9 | 5MG | $93 | 2026-04-30 | Buy |
| TCI Chemical | C3956 | CGP 37157 | 75450-34-9 | 25MG | $325 | 2026-04-30 | Buy |
| Cayman Chemical | 15611 | CGP 37157 ≥95% | 75450-34-9 | 5mg | $54 | 2026-04-30 | Buy |
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one Chemical Properties, Uses, Production
Description
CGP-37157 (75450-34-9) inhibitsthe mitochondrial Na+-Ca2+exchanger (NCX) in isolated heart mitochondria, IC50=0.36 μM.1Does not inhibit the plasmalemmal NCX.2 Also inhibits voltage-gated Ca2+channels in intact cells and therefore its use in cellular studies must employ adequate controls.3 Prevents sudden death in a Guinea pig model of heart failure.4Displays pronounced cytoprotective effects in chromaffin cells5and in neuronal injury models.6Blood-brain barrier permeant.
Uses
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one is a specific inhibitor of the mitochondrial Na+/Ca2+ exchanger.
Uses
CGP-37157 has been used as a mitochondrial sodium-calcium exchanger (mNCX) inhibitor to study the role of normal mitochondrial calcium dynamics in sustaining dendritic spinogenesis.
Definition
ChEBI: 7-chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2-one is a benzothiazepine.
General Description
CGP-37157 is a benzothiazepine compound, which is derived from clonazepam. It functions as a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) antagonist and ryanodine receptor channels (RyR) agonist. CGP-37157 regulates intracellular signaling of calcium in smooth, cardiac and skeletal muscle cells and non-muscle systems.
Biological Activity
Selective antagonist of the mitochondrial Na + -Ca 2+ exchanger (IC 50 = 0.4 μ M).
Biochem/physiol Actions
Specific inhibitor of mitochondrial Na+/Ca2+ exchange as well as sarcoplasmic reticulum calcium-stimulated ATPase and possibly other calcium channels.
storage
Room temperature
References
[1] D A COX. Selectivity of inhibition of Na(+)-Ca2+ exchange of heart mitochondria by benzothiazepine CGP-37157.[J]. Journal of Cardiovascular Pharmacology, 1993, 21 4: 595-599. DOI:10.1097/00005344-199304000-00013
[2] IYUKI NAMEKATA Hikaru T Shogo Hamaguchi. Pharmacological discrimination of plasmalemmal and mitochondrial sodium-calcium exchanger in cardiomyocyte-derived H9c2 cells.[J]. Biological & pharmaceutical bulletin, 2015, 38 1: 147-150. DOI:10.1248/bpb.b14-00525
[3] KYLE T BARON Stanley A T. CGP37157 modulates mitochondrial Ca2+ homeostasis in cultured rat dorsal root ganglion neurons[J]. European journal of pharmacology, 1997, 340 2: Pages 295-300. DOI:10.1016/s0014-2999(97)01433-7
[4] TING LIU. Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a Guinea pig model of heart failure.[J]. Circulation research, 2014, 115 1: 44-54. DOI:10.1161/circresaha.115.303062
[5] SANTOS M NICOLAU. Mitochondrial Na+/Ca2+-exchanger blocker CGP37157 protects against chromaffin cell death elicited by veratridine.[J]. Journal of Pharmacology and Experimental Therapeutics, 2009, 330 3: 844-854. DOI:10.1124/jpet.109.154765
[6] A RUIZ C M E Alberdi. CGP37157, an inhibitor of the mitochondrial Na+/Ca2+ exchanger, protects neurons from excitotoxicity by blocking voltage-gated Ca2+ channels[J]. Cell Death & Disease, 2014, 5 4: e1156-e1156. DOI:10.1038/cddis.2014.134
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one Preparation Products And Raw materials
Raw materials
Preparation Products
7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepin-2(3H)-one Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Ascent Scientific | 4401179829988 | customerservice@ascentscientific.co.uk | United Kingdom | 279 | 60 |
| SHANGHAI FORTUNE CHEMICAL TECHNOLOGY CO., LTD | 13816107857 | sales@fortunechem-sh.com | China | 981 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 | sales@finetechnology-ind.com | China | 9331 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| SPIRO PHARMA | eric_feng1954@126.com | China | 9239 | 55 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd | 0431-80534353 19917294565 | et@chemextension.com | China | 3904 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
