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4-Methylbenzenesulfonhydrazide

4-Methylbenzenesulfonhydrazide Structure
4-Methylbenzenesulfonhydrazide structure
CAS No.
1576-35-8
Chemical Name:
4-Methylbenzenesulfonhydrazide
Synonyms
TsNHNH2;P-TOLUENESULFONYL HYDRAZIDE;TSH;Tosylhydrazine;PTSH;TOSYLHYDRAZIDE;TOLUENE-4-SULFONIC ACID HYDRAZIDE;P-TOLUENESULFONHYDRAZIDE;P-TOLUENESULFONYLHYDRAZINE;4-TOLUENESULFONYL HYDRAZIDE
CBNumber:
CB6156664
Molecular Formula:
C7H10N2O2S
Molecular Weight:
186.23
MDL Number:
MFCD00007588
MOL File:
1576-35-8.mol
MSDS File:
SDS
Last updated:2026-06-25 14:48:23
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4-Methylbenzenesulfonhydrazide Properties

Melting point 103-108 °C(lit.)
Boiling point 340.5±35.0 °C(Predicted)
Density 1.42g/cm3
vapor pressure 0Pa at 20℃
refractive index 1.5400 (estimate)
Flash point 60°C
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 5g/l
form Powder
pka 9.39±0.10(Predicted)
color White or off-white to slightly grayish
Water Solubility 5 g/L (15 ºC)
Sensitive Moisture Sensitive
BRN 610130
Stability Light Sensitive
InChI 1S/C7H10N2O2S/c1-6-2-4-7(5-3-6)12(10,11)9-8/h2-5,9H,8H2,1H3
InChIKey ICGLPKIVTVWCFT-UHFFFAOYSA-N
SMILES Cc1ccc(cc1)S(=O)(=O)NN
LogP 0.55 at 25℃
CAS DataBase Reference 1576-35-8(CAS DataBase Reference)
FDA UNII LR93R5002M
EPA Substance Registry System Benzenesulfonic acid, 4-methyl-, hydrazide (1576-35-8)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)
GHS05
Signal word  Warning
Hazard statements  H290
Precautionary statements  P234-P390
PPE Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Hazard Codes  F,Xn
Risk Statements  11-22-44-2017/11/22
Safety Statements  16-26
RIDADR  UN 3226 4.1
WGK Germany  3
RTECS  MW0210000
TSCA  TSCA listed
HazardClass  4.1
PackingGroup  II
HS Code  29280090
Storage Class 5.2 - Organic peroxides and self-reacting hazardous materials
Hazard Classifications Acute Tox. 3 Oral
Aquatic Chronic 2
Self-react. D
REACH Registrations Active
Limited Quantities 1.0 Kg (2.2 lbs)
Excepted Quantities Not Permitted as Excepted Quantity
NFPA 704
2
3 3

4-Methylbenzenesulfonhydrazide price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 132004 p-Toluenesulfonyl hydrazide 97% 1576-35-8 25g $60.2 2026-04-30 Buy
Sigma-Aldrich 132004 p-Toluenesulfonyl hydrazide 97% 1576-35-8 100g $115 2026-04-30 Buy
Sigma-Aldrich RAB0502 Human Thyroid Stimulating Hormone ELISA Kit for serum, plasma, cell culture supernatants and urine 1576-35-8 1kit $608 2026-04-30 Buy
Usbiological 290785 p-Toluenesulfonyl hydrazide Asreported 1576-35-8 100g $388 2026-06-03 Buy
Usbiological 290785 p-Toluenesulfonyl hydrazide Asreported 1576-35-8 250g $598 2026-06-03 Buy
Product number Packaging Price Buy
132004 25g $60.2 Buy
132004 100g $115 Buy
RAB0502 1kit $608 Buy
290785 100g $388 Buy
290785 250g $598 Buy

4-Methylbenzenesulfonhydrazide Chemical Properties, Uses, Production

Uses

p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.

Chemical Properties

white to off-white powder

Uses

4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones.

Application

p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4',3'-c]pyridines and 1,2,3-selenadiazole derivatives.

Reactions

4-Methylbenzenesulfonhydrazide as hydrogen donor in reduction reactions:reduction reaction of 4-MethylbenzenesulfonhydrazideA base-mediated semihydrogenation of ynamides using 4-Methylbenzenesulfonhydrazide (p-toluenesulfonyl hydrazide) as an inexpensive and easy-to-handle hydrogen donor provides the thermodynamically unfavorable Z-enamides exclusively without overhydrogenation and reduction of other functional groups.

Hazard

4-Methylbenzenesulphonhydrazide is a flammable liquid which may explode in confined spaces at high temperatures. Contact may cause skin irritation and mild eye irritation. It is toxic if swallowed.

Flammability and Explosibility

Not classified

Synthesis

Tosyl chloride

98-59-9

4-Methylbenzenesulfonhydrazide

1576-35-8

General procedure for the synthesis of p-toluenesulfonyl hydrazide from p-toluenesulfonyl chloride: general method: preparation of p-toluenesulfonyl hydrazide. A mixed solution of water (300 mL) and hydrazine hydrate (12.5 g; 0.25 mol) was cooled to about 5 °C in an ice-water bath. The reaction temperature was kept below 8 °C while a tetrahydrofuran (50 mL) solution of p-toluenesulfonyl chloride (5.54 g, 0.025 mol) was slowly added under stirring. After the addition was completed, the reaction mixture was continued to be stirred at room temperature for 30 min. Subsequently, the tetrahydrofuran was removed by distillation under reduced pressure. The white solid product was isolated by filtration and washed with cold water (3 x 15 mL). Finally, the product was dried in air overnight to give pure p-toluenesulfonyl hydrazide (4.86 g; 89% yield).

Purification Methods

Dissolve the 4-Methylbenzenesulfonhydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.]

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4629 - 4636
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3397 - 3407
[3] Archiv der Pharmazie, 2014, vol. 347, # 8, p. 576 - 588
[4] Patent: CN107056871, 2017, A. Location in patent: Paragraph 0022; 0030; 0038
[5] Journal of Molecular Structure, 2017, vol. 1133, p. 80 - 89

4-Methylbenzenesulfonhydrazide synthesis

104-15-4
1576-35-8
Synthesis of 4-Methylbenzenesulfonhydrazide from p-Toluenesulfonic acid

4-Methylbenzenesulfonhydrazide Preparation Products And Raw materials

Raw materials

Hydrazine sulfate Tosyl chloride p-Toluenesulfonic acid Hydrazine hydrate Water
Tetrahydrofuran

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Preparation Products

4,4'-Dimethylbiphenyl Di-p-tolylacetylene Phenyl p-tolyl sulfone 1,2-Bis(p-tolylsulfonyl)hydrazine, N,Nμ-Ditosylhydrazine, 4-Methylbenzenesulfonic acid 2-[(4-methylphenyl)sulfonyl]hydrazide 4-(Methylphenyl)sulfonylacetonitrile
N-Cyclohexyl-4-methylbenzenesulfonamide P-TOLYL DISULFIDE Bay 11-7082 Dihydroeugenol 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole

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4-Methylbenzenesulfonhydrazide Suppliers

Global Suppliers ( 577)
Supplier Tel Email Country ProdList Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 13396369453 18678026865 sdfantai@163.com China 904 58
Shouguang Nuomeng Chemical Co Ltd. 0536-5399456 13869682027 holly@nuomengchem.com China 47 58
Huangshi Jingsheng Biotechnology Co., Ltd. 17771199833; 17771199833 351013952@qq.com China 3812 58
Jiangxi Boye Medical Technology Co., Ltd 027-18971341812/18971341812 18971341812 anikay@boyechemicals.com China 480 58
Shanghai Qihong Pharmaceutical Technology Co., Ltd. 13482681346 18117455885 qihongchem@163.com China 8731 58
Henan Dobe Chemical Co. , Ltd. 0370-6999054 17550096163 3189729795@qq.com China 3000 58
Hubei Hanqing Biopharmaceutical Technology Co., Ltd 15827479330 3583890861@qq.com China 4992 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 010-88425576 sales@dhltchem.com China 793 59
Supplier Advantage
Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. 58
Shouguang Nuomeng Chemical Co Ltd. 58
Huangshi Jingsheng Biotechnology Co., Ltd. 58
Jiangxi Boye Medical Technology Co., Ltd 58
Shanghai Qihong Pharmaceutical Technology Co., Ltd. 58
Henan Dobe Chemical Co. , Ltd. 58
Hubei Hanqing Biopharmaceutical Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Beijing Donghualituo Techonlogy Development Co.,Ltd. 59

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View Latest Price from 4-Methylbenzenesulfonhydrazide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Methylbenzenesulfonhydrazide pictures 2026-09-02 4-Methylbenzenesulfonhydrazide
1576-35-8
 $1.00-100.00 1KG 99% Henan Fengda Chemical Co., Ltd
P-Toluenesulfonyl hydrazine, TSH, 4-Methylbenzenesulfonhydrazide pictures 2026-08-25 P-Toluenesulfonyl hydrazine, TSH, 4-Methylbenzenesulfonhydrazide
1576-35-8
 $6200.00 1KG 98% 200 tons per month Shouguang Nuomeng Chemical Co Ltd.
4-Methylbenzenesulfonhydrazide pictures 2026-08-21 4-Methylbenzenesulfonhydrazide
1576-35-8
 $11110.00 1Tons 99% 100Tons Hebei Dangtong Import and export Co LTD

4-Methylbenzenesulfonhydrazide Spectrum

4-Methylbenzenesulfonhydrazide(1576-35-8)MS4-Methylbenzenesulfonhydrazide(1576-35-8)1HNMR4-Methylbenzenesulfonhydrazide(1576-35-8)13CNMR4-Methylbenzenesulfonhydrazide(1576-35-8)IR14-Methylbenzenesulfonhydrazide(1576-35-8)IR24-Methylbenzenesulfonhydrazide(1576-35-8)Raman

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n-toluolsulphonylhydrazine p-toluenesulfohydrazide p-tolylsulfonyl-hydrazin 4-METHYL-1-BENZENESULFONYL HYDRAZIDE P-Benzene Sulfonyl Hydrazine p-Toluenesulfonic acid hydrazide, p-Toluenesulfonyl hydrazide, Tosylhydrazide Foamer TSH p-Toluenesulfonhydrazide, p-Toluenesulfonic acid hydrazide, p-Toluenesulfonyl hydrazide, Tosylhydrazide p-Toluenesulfonhydrazide ,95% 1-Tosylhydrazine p-Methylbenzenesulfonohydrazide 4-Methylbenzenesulfonhydrazide,97% p-Toluenesulfonyl hydrazide,p-Toluenesulfonhydrazide, p-Toluenesulfonic acid hydrazide, p-Toluenesulfonyl hydrazide, Tosylhydrazide 4-Methylbenzenesulfo 4-Methylbenzenesulfonhydrazide, 97% 100GR 4-Methylbenzenesulfonhydrazide, 97% 25GR 4-TOLUENESULFONOHYDRAZIDE FOR SYNTHESIS TSH 4-Methylbenzenesulfonhydrazide p-Toluenesulfonyl hydrazide 97% p-Toluenesulfonyl hydrazide, 98%+ ANTI-TSH antibody produced in mouse P-Toluenesulfonyl Hydrazide (TSH) p-Toluenesulfonyl Hydrazide P-Toluenesulfonyl hydrazine, TSH, 4-Methylbenzenesulfonhydrazide Posaconazole Impurity DBGS Free Base 4-Methylbenzenesulfonhydrazide 4-TOLUENESULFONIC ACID HYDRAZIDE 4-TOLUENESULFONOHYDRAZIDE LABOTEST-BB LT00071719 P-TOLYL HYDRAZIDE P-TOLUENESULPHONYL HYDRAZIDE P-TOLUENESULFONIC ACID HYDRAZIDE SPECS AC-907/25014186 TOLUENE-4-SULPHONHYDRAZIDE toluene-4-sulphonohydrazide TOLUENE-4-SULFONOHYDRAZIDE 4-Methylbenzenesulphonyl hydrazide p-Toluenesulphonohydrazide TOLUENE-P-SULFONYL HYDRAZIDE (TSH) PARA-TOLUENESULFONHYDRAZIDE, 99% P-TOLUENESULFONYL HYDRAZIDE,97% P-Toluenesulfonyl hydrazide (PTSH) 4-methyl-benzenesulphonic acid, hydrazine PARA-TOLUENESULPHONOHYDRAZIDE PARA-TOLUENESULPHONHYDRAZIDE PARA-TOLUENESULPHOHYDRAZIDE 4-methylbenzenesulfonicacidhydrazide 4-methyl-benzenesulfonicacihydrazide 4-Methylbenzenesulfonhydrazider 4-TOLUENESULFONYL H Benzenesulfonicacid,4-methyl-,hydrazide BlowingagentTSH p-Toluenesulfonyl Hydrazide > Posaconazole Impurity DBGS benzene-1-suL fonohydrazide 4-Methylbenzenesulfonhydrazide ISO 9001：2015 REACH Posaconazole Impurity 112