4-Methylbenzenesulfonhydrazide
- CAS No.
- 1576-35-8
- Chemical Name:
- 4-Methylbenzenesulfonhydrazide
- Synonyms
- TSH;P-TOLUENESULFONYL HYDRAZIDE;PTSH;TOSYLHYDRAZIDE;Tosylhydrazine;TOLUENE-4-SULFONIC ACID HYDRAZIDE;P-TOLUENESULFONHYDRAZIDE;P-TOLUENESULFONYLHYDRAZINE;Toluol-4-sulfonohydrazid;p-Toluenesulfonohydrazide
- CBNumber:
- CB6156664
- Molecular Formula:
- C7H10N2O2S
- Molecular Weight:
- 186.23
- MDL Number:
- MFCD00007588
- MOL File:
- 1576-35-8.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| p-Toluenesulfonyl hydrazide 97% | 132004 | 25g | $56.6 |
| p-Toluenesulfonyl hydrazide 97% | 132004 | 100g | $108 |
| Human Thyroid Stimulating Hormone ELISA Kit for serum, plasma, cell culture supernatants and urine | RAB0502 | 1kit | $569 |
| p-Toluenesulfonyl hydrazide 97% | 132004 | 500g | $229 |
| p-Toluenesulfonyl hydrazide | 290785 | 100g | $388 |
| More product size | |||
| Melting point | 103-108 °C(lit.) |
|---|---|
| Boiling point | 340.5±35.0 °C(Predicted) |
| Density | 1.42g/cm3 |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.5400 (estimate) |
| Flash point | 60°C |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | 5g/l |
| form | Powder |
| pka | 9.39±0.10(Predicted) |
| color | White or off-white to slightly grayish |
| Water Solubility | 5 g/L (15 ºC) |
| Sensitive | Moisture Sensitive |
| BRN | 610130 |
| Stability | Light Sensitive |
| InChI | 1S/C7H10N2O2S/c1-6-2-4-7(5-3-6)12(10,11)9-8/h2-5,9H,8H2,1H3 |
| InChIKey | ICGLPKIVTVWCFT-UHFFFAOYSA-N |
| SMILES | Cc1ccc(cc1)S(=O)(=O)NN |
| LogP | 0.55 at 25℃ |
| CAS DataBase Reference | 1576-35-8(CAS DataBase Reference) |
| FDA UNII | LR93R5002M |
| EPA Substance Registry System | Benzenesulfonic acid, 4-methyl-, hydrazide (1576-35-8) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H290 | |||||||||
| Precautionary statements | P234-P390 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 11-22-44-2017/11/22 | |||||||||
| Safety Statements | 16-26 | |||||||||
| RIDADR | UN 3226 4.1 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MW0210000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29280090 | |||||||||
| Storage Class | 5.2 - Organic peroxides and self-reacting hazardous materials | |||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 2 Self-react. D |
|||||||||
| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Not Permitted as Excepted Quantity | |||||||||
| NFPA 704 |
|
4-Methylbenzenesulfonhydrazide price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 132004 | p-Toluenesulfonyl hydrazide 97% | 1576-35-8 | 25g | $56.6 | 2025-07-31 | Buy |
| Sigma-Aldrich | 132004 | p-Toluenesulfonyl hydrazide 97% | 1576-35-8 | 100g | $108 | 2025-07-31 | Buy |
| Sigma-Aldrich | RAB0502 | Human Thyroid Stimulating Hormone ELISA Kit for serum, plasma, cell culture supernatants and urine | 1576-35-8 | 1kit | $569 | 2025-07-31 | Buy |
| Sigma-Aldrich | 132004 | p-Toluenesulfonyl hydrazide 97% | 1576-35-8 | 500g | $229 | 2025-07-31 | Buy |
| Usbiological | 290785 | p-Toluenesulfonyl hydrazide | 1576-35-8 | 100g | $388 | 2021-12-16 | Buy |
4-Methylbenzenesulfonhydrazide Chemical Properties,Uses,Production
Uses
p-Toluenesulfonyl Hydrazide is a reactant that has been used in the synthesis of paspaline.
Chemical Properties
white to off-white powder
Uses
4-Methylbenzenesulfonhydrazide was widely used reagent for the preparation of tosylhydrazones.
Application
p-Toluenesulfonyl hydrazide is used as a reagent for the preparation of tosylhydrazones. It was used to prepare dipyrazolo[1,5-a:4',3'-c]pyridines and 1,2,3-selenadiazole derivatives.
Reactions
4-Methylbenzenesulfonhydrazide as hydrogen donor in reduction reactions:
A base-mediated semihydrogenation of ynamides using 4-Methylbenzenesulfonhydrazide (p-toluenesulfonyl
hydrazide) as an inexpensive and easy-to-handle hydrogen donor provides the
thermodynamically unfavorable Z-enamides exclusively without
overhydrogenation and reduction of other functional groups.
Flammability and Explosibility
Not classified
Synthesis
98-59-9
1576-35-8
General procedure for the synthesis of p-toluenesulfonyl hydrazide from p-toluenesulfonyl chloride: general method: preparation of p-toluenesulfonyl hydrazide. A mixed solution of water (300 mL) and hydrazine hydrate (12.5 g; 0.25 mol) was cooled to about 5 °C in an ice-water bath. The reaction temperature was kept below 8 °C while a tetrahydrofuran (50 mL) solution of p-toluenesulfonyl chloride (5.54 g, 0.025 mol) was slowly added under stirring. After the addition was completed, the reaction mixture was continued to be stirred at room temperature for 30 min. Subsequently, the tetrahydrofuran was removed by distillation under reduced pressure. The white solid product was isolated by filtration and washed with cold water (3 x 15 mL). Finally, the product was dried in air overnight to give pure p-toluenesulfonyl hydrazide (4.86 g; 89% yield).
Purification Methods
Dissolve the 4-Methylbenzenesulfonhydrazide in hot MeOH (~1g/4mL), filter through Celite and precipitate the material by adding 2-2.5 volumes of distilled H2O. Dry it in air or in a vacuum. [Fiedman et al. Org Synth Coll Vol V 1055 1973, Beilstein 11 II 66.]
References
[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 17, p. 4629 - 4636
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 13, p. 3397 - 3407
[3] Archiv der Pharmazie, 2014, vol. 347, # 8, p. 576 - 588
[4] Patent: CN107056871, 2017, A. Location in patent: Paragraph 0022; 0030; 0038
[5] Journal of Molecular Structure, 2017, vol. 1133, p. 80 - 89
4-Methylbenzenesulfonhydrazide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shouguang Nuomeng Chemical Co Ltd. | 536-5119508 18363669993; | export@nuomengchem.com | China | 46 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20128 | 58 |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +8618627948422 | sale@hdimpurity.com | China | 3681 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| Moxin Chemicals | +86-17320513646 +8617320513646 | anna@molcoo.com | China | 10000 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Dalian Richfortune Chemicals Co., Ltd | +86-86-411-84820922 +86-8613904096939 | sales@richfortunechem.com | China | 305 | 57 |
View Lastest Price from 4-Methylbenzenesulfonhydrazide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-30 | 4-Methylbenzenesulfonhydrazide
1576-35-8
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2026-01-23 | Posaconazole Impurity 112 | US $0.00-0.00 / mg | 10mg | 98% | 500mg | ShenZhen H&D Pharmaceutical Technology Co., LTD | |
 |
2025-12-16 | Anastrozole Impurity
1576-35-8
|
US $0.00-0.00 / mg | 10mg | 98 | 10000000 | Moxin Chemicals |
-
- 4-Methylbenzenesulfonhydrazide
1576-35-8
- US $1.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Posaconazole Impurity 112
- US $0.00-0.00 / mg
- 98%
- ShenZhen H&D Pharmaceutical Technology Co., LTD
-
- Anastrozole Impurity
1576-35-8
- US $0.00-0.00 / mg
- 98
- Moxin Chemicals
