ChemicalBook >> CAS DataBase List >>(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one structure

CAS No.: 1971920-73-6

Chemical Name:: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one

Synonyms: Tolebrutinib;PRN-2246;SAR442168;(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one;Tolebrutinib, SAR442168;Tolebrutinib, 10 mM in DMSO;Tolebrutinib/SAR442168/PRN2246;Tolebrutinib (SAR442168) ，E0041;Tolebrutinib,1971920-73-6,Pharmaceutical Chemicals;(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-

CBNumber:: CB73336057

Molecular Formula:: C26H25N5O3

Molecular Weight:: 455.51

MDL Number:: MFCD32710277

MOL File:: 1971920-73-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:09:42

Product description	Number	Pack Size	Price
Tolebrutinib ≥95%	37723	1mg	$28
Tolebrutinib ≥95%	37723	5mg	$76
Tolebrutinib ≥95%	37723	10mg	$138
Tolebrutinib ≥95%	37723	25mg	$241
Tolebrutinib	FT179188	5mg	$900

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(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Properties

Boiling point	698.1±65.0 °C(Predicted)
Density	1.334±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 100 mg/mL (219.53 mM; Need ultrasonic)
pka	7.03±0.20(Predicted)
form	Solid
color	Off-white to light yellow
InChIKey	KOEUOFPEZFUWRF-LJQANCHMSA-N
SMILES	C1(N)=NC=CC2N([C@@H]3CCCN(C(=O)C=C)C3)C(=O)N(C3=CC=C(OC4=CC=CC=C4)C=C3)C1=2
FDA UNII	8CZ82ZYY9X

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P280-P301+P312-P302+P352-P305+P351+P338

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	37723	Tolebrutinib ≥95%	1971920-73-6	1mg	$28	2026-04-30	Buy
Cayman Chemical	37723	Tolebrutinib ≥95%	1971920-73-6	5mg	$76	2026-04-30	Buy
Cayman Chemical	37723	Tolebrutinib ≥95%	1971920-73-6	10mg	$138	2026-04-30	Buy
Cayman Chemical	37723	Tolebrutinib ≥95%	1971920-73-6	25mg	$241	2026-04-30	Buy
Biosynth	FT179188	Tolebrutinib	1971920-73-6	5mg	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
37723	1mg	$28	Buy
37723	5mg	$76	Buy
37723	10mg	$138	Buy
37723	25mg	$241	Buy
FT179188	5mg	$900	Buy

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Chemical Properties,Uses,Production

Uses

Tolebrutinib is a drug candidate; used in preparation of Dihydroimidazopyridine derivatives for treatment of Bruton''s tyrosine kinase related diseases.

in vivo

PRN2246 (1-5 mg/kg; p.o. q.d. for 28 d) produces dose-dependent protection from in myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) model^[2].

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Suppliers

Global( 88)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19935	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	+8617735180244	mike_yan@xuanranglobal.com	CHINA	4011	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	+86-519-519-86686860 +86-18795626222	ning@guiding-bio.com	China	299	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49709	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	38999	58
Wuhan Topule Biopharmaceutical Co., Ltd	+86-18327326525	masar@topule.com	China	8433	58
HANGZHOU LEAP CHEM CO., LTD.	+86-571-87711850 +86-15355479329	market18@leapchem.com	China	43303	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	+8618235132063	sales@tihondan.com	China	3766	58
Suzhou ARTK Medchem Co., Ltd.	+86-18168183658	sales1@artkmedchem.com	China	39007	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
BOC Sciences	58
Shanxi Xuanran Import and Export Trade Co., Ltd.	58
Changzhou Guiding Bio-Tech. Co.,Ltd.	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
HANGZHOU LEAP CHEM CO., LTD.	58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd	58
Suzhou ARTK Medchem Co., Ltd.	58

View Lastest Price from (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-17	(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)- 1971920-73-6	$1.00-8.00	1kg	99%		Henan Fengda Chemical Co., Ltd

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-
1971920-73-6
$1.00-8.00
99%
Henan Fengda Chemical Co., Ltd

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Spectrum

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one(1971920-73-6)¹HNMR

1971920-73-6((R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one)Related Search:

Tirabrutinib Remibrutinib N-(5-((5-(4-Acetylpiperazine-1-carbonyl)-4-methoxy-2-methylphenyl)thio)thiazol-2-yl)-4-(((3,3-dimethylbutan-2-yl)amino)methyl)benzamide Poseltinib ONO-4059 (hydrochloride)

AVL-292

1of2

(R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one 2H-Imidazo[4,5-c]pyridin-2-one, 4-amino-1,3-dihydro-1-[(3R)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-3-(4-phenoxyphenyl)- (R,E)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-(penta-2,4-dien-2-yloxy)phenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one Tolebrutinib, (R)-1-(1-Acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1H-imidazo[4,5-c]pyridin-2(3H)-one multiple,PRN 2246,SAR-442168,inhibit,Bruton tyrosine kinase,Tolebrutinib,sclerosis,Bruton,kinase,SAR 442168,tyrosine,Inhibitor,Btk,PRN-2246 Tolebrutinib, SAR442168 (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)- Tolebrutinib/SAR442168/PRN2246 4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one Tolebrutinib, 10 mM in DMSO Tolebrutinib (SAR442168) ，E0041 (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-3-(4-phenoxyphenyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one PRN-2246 SAR442168 Tolebrutinib Tolebrutinib,1971920-73-6,Pharmaceutical Chemicals 1971920-73-6 Tolebrutinib