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N-Boc-piperidine-2-methanol

N-Boc-piperidine-2-methanol structure

CAS No.: 157634-00-9

Chemical Name:: N-Boc-piperidine-2-methanol

Synonyms: tert-Butyl 2-(hydroxymethyl)piperidine-1-carboxylate;1-BOC-2-HYDROXYMETHYL-PIPERIDINE;BOC-2-PIPERIDYLMETHANOL;1-Boc-2-piperidinemethanol;N-Boc-2-piperidinecarbinol;n-boc-piperidine-2-methanol;1-Boc-Piperidine-2-Methanol;1-N-Boc-2-piperidinemethanol;N-Boc-2 - piperidinyl alcohol;N-Boc-piperidine-2-Methanol 97%

CBNumber:: CB7340947

Molecular Formula:: C11H21NO3

Molecular Weight:: 215.29

MDL Number:: MFCD04114966

MOL File:: 157634-00-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:23:06

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N-Boc-piperidine-2-methanol Properties

Melting point	74-78 °C
Boiling point	308.0±15.0 °C(Predicted)
Density	1.059±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	soluble in Methanol
pka	15.08±0.10(Predicted)
form	Crystalline Powder
color	White
InChI	InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-7-5-4-6-9(12)8-13/h9,13H,4-8H2,1-3H3
InChIKey	PZTAGFCBNDBBFZ-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCCCC1CO
CAS DataBase Reference	157634-00-9(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H301-H315-H319-H335

Precautionary statements

P261-P301+P310-P305+P351+P338-P280a-P301+P310a-P405-P501a

target organs

Respiratory system

PPE

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Hazard Codes

Risk Statements

25-36/37/38

Safety Statements

26-45

RIDADR

UN 2811

WGK Germany

HazardClass

6.1

HazardClass

IRRITANT

HS Code

29333990

Storage Class

6.1D - Non-combustible acute toxic Cat.3
toxic hazardous materials or hazardous materials causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	1
2		0

N-Boc-piperidine-2-methanol price More Price(66)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	681296	N-Boc-piperidine-2-methanol 97%	157634-00-9	1g	$94	2023-06-20	Buy
Sigma-Aldrich	681296	N-Boc-piperidine-2-methanol 97%	157634-00-9	10g	$290	2023-06-20	Buy
TCI Chemical	B3755	1-(tert-Butoxycarbonyl)-2-piperidinemethanol >97.0%(GC)	157634-00-9	5g	$67	2026-04-30	Buy
TCI Chemical	B3755	1-(tert-Butoxycarbonyl)-2-piperidinemethanol >97.0%(GC)	157634-00-9	25g	$199	2026-04-30	Buy
Usbiological	265689	1-Boc-2-hydroxymethyl-piperidine Asreported	157634-00-9	2g	$370	2026-06-03	Buy

Product number	Packaging	Price	Buy
681296	1g	$94	Buy
681296	10g	$290	Buy
B3755	5g	$67	Buy
B3755	25g	$199	Buy
265689	2g	$370	Buy

N-Boc-piperidine-2-methanol Chemical Properties,Uses,Production

Chemical Properties

Solid

Uses

Reactant for:

Julia coupling for synthesis of corydendramine A
Cyclization-functionalization of nitrogen-containing dienes

Reactant for synthesis of:

Heterocyclic compounds
Anthranilamide inhibitors of factor Xa
Human GnRH receptor antagonists
Sphingosine-1-phosphate receptor agonists

Synthesis

24424-99-5

3433-37-2

157634-00-9

The general procedure for the synthesis of 1-Boc-2-piperidinemethanol from di-tert-butyl dicarbonate and 2-piperidinemethanol is as follows: 1. 2-Piperidinemethanol (3.0 g, 25.60 mmol) was dissolved in dichloromethane (DCM, 100 mL) under stirring. 2. triethylamine (14.5 mL, 91.08 mmol) was added to the above solution in batches, followed by di-tert-butyl dicarbonate (7.2 g, 31.0 mmol). 3. The reaction mixture was stirred at room temperature for 16 hours. 4. Upon completion of the reaction, water (70 mL) was added for stratification to separate the organic layer. 5. The organic layer was washed with water (2 x 50 mL) and then dried with anhydrous sodium sulfate (Na2SO4). 6. The dried organic layer was filtered and concentrated under vacuum to give 1-Boc-2-piperidinemethanol (6.0 g, quantitatively) as a light brown oil, which can be used without further purification. The nuclear magnetic resonance hydrogen spectrum (1H NMR, CDCl3) data were as follows: δ 4.42-4.22 (1H, m), 4.05-3.91 (1H, m), 3.89-3.77 (1H, m), 3.71-3.53 (1H, m), 2.97-2.81 (1H, m), 2.32-2.08 (1H, m), 1.90 (1H, s ), 1.77-1.57 (3H, m), 1.54 (1H, s), 1.52-1.38 (10H, m).

References

[1] Patent: WO2007/141504, 2007, A1. Location in patent: Page/Page column 57
[2] Organic Letters, 1999, vol. 1, # 4, p. 667 - 670
[3] Journal of Organic Chemistry, 1996, vol. 61, # 17, p. 6040 - 6043
[4] Tetrahedron Asymmetry, 1998, vol. 9, # 11, p. 1951 - 1965
[5] Tetrahedron Letters, 2015, vol. 56, # 46, p. 6478 - 6483

N-Boc-piperidine-2-methanol synthesis

Synthesis of N-Boc-piperidine-2-methanol from Di-tert-butyl dicarbonate and 2-(Hydroxymethyl)piperidine

N-Boc-piperidine-2-methanol Preparation Products And Raw materials

Raw materials

Di-tert-Butyl malonate Di-tert-butyl dicarbonate 2-(Hydroxymethyl)piperidine Dichloromethane Triethylamine

Preparation Products

N-Boc-3,4-dihydro-2H-pyridine 2-Piperidinemethanol hydrochloride 2-ethenylpiperidine

N-Boc-piperidine-2-methanol Suppliers

Global( 241)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	0311-89250318 13582355795	master@sjzsdyn.com	China	2776	65
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	65
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Lastest Price from N-Boc-piperidine-2-methanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-11-03	N-Boc-piperidine-2-methanol 157634-00-9	$10.00	1kg	99%	100tons	Anhui Zhongda Biotechnology Co., Ltd
2023-06-26	N-Boc-piperidine-2-methanol 157634-00-9	$220.00	10g	99%	500kg/month	Hebei Mingeng Biotechnology Co., Ltd
2022-02-26	N-Boc-piperidine-2-methanol 157634-00-9		1KG	98%	100	Jinan Ande Pharmaceutical Co.,Ltd.

N-Boc-piperidine-2-methanol
157634-00-9
$10.00
99%
Anhui Zhongda Biotechnology Co., Ltd

N-Boc-piperidine-2-methanol
157634-00-9
$220.00
99%
Hebei Mingeng Biotechnology Co., Ltd

N-Boc-piperidine-2-methanol
157634-00-9
98%
Jinan Ande Pharmaceutical Co.,Ltd.

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1of4

TERT-BUTYL 2-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-Boc-2-(hydroxymethyl)piperidine n-boc-piperidine-2-methanol BOC-2-PIPERIDYLMETHANOL 2-HYDROXYMETHYL-1-N-BOC-PIPERIDINE 2-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-N-Boc-2-piperidinemethanol 1-Boc-2-piperidinemethanol 1-Boc-Piperidine-2-Methanol 1-TERT-BUTOXYCARBONYL-2-PIPERIDINEMETHANOL, N-BOC-2-PIPERIDINEMETHANOL 1-Piperidinecarboxylic acid, 2-(hydroxyMethyl)-, 1,1-diMethylethylester N-tert-Butoxycarbonyl-2-piperidineMethanol 1-Boc-2-piperidinemethanol 1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperidine 1-Boc-2-(hydroxymethyl)piperidine N-Boc-2-PiperidineMethanol or N-tert-Butyloxycarbonyl-2-piperidineMethanol or N-Boc-2-(hydroxyMethyl)piperidine N-Boc-piperidine-2-Methanol 97% tert-Butoxycarbonyl-2-(hydroxymethyl)piperidine 1-BOC-2-HYDROXYMETHYL-PIPERIDINEChemicalBook 1-(tert-Butoxycarbonyl)-2-piperidinemethanol > N-Boc-2 - piperidinyl alcohol 1-(tert-Butoxycarbonyl)-2-(hydroxymethyl)piperidine (+/-)-1-Boc-2-(hydroxymethyl)piperidine, 97%, N-Boc-piperidine-2-methanol N-Boc-2-piperidinecarbinol 1-BOC-2-HYDROXYMETHYL-PIPERIDINE tert-Butyl 2-(hydroxymethyl)piperidine-1-carboxylate 157634-00-9 Building Blocks Heterocyclic Building Blocks Piperidines Heterocyclic Compounds pharmacetical Piperidine