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N-Boc-piperidine-3-methanol

N-Boc-piperidine-3-methanol structure

CAS No.: 116574-71-1

Chemical Name:: N-Boc-piperidine-3-methanol

Synonyms: TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE;3-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;CAS:116574-71-1;N-BOC-(3S)-PIP(3-CH2OH);1-Boc-3-piperidinemethanol;N-Boc-3-piperidinecarbinol;N-Boc-piperidine-3-methanol;N-Boc-piperidine-5-Methanol;N-Boc-piperidine-6-Methanol;N-Boc-piperidine-7-Methanol

CBNumber:: CB7157299

Molecular Formula:: C11H21NO3

Molecular Weight:: 215.29

MDL Number:: MFCD03094733

MOL File:: 116574-71-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:26:38

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N-Boc-piperidine-3-methanol Properties

Melting point	77-81 °C
Boiling point	308.0±15.0 °C(Predicted)
Density	1.059±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Soluble in methanol and dimethylformamide(DMF).
form	powder to crystal
pka	14.93±0.10(Predicted)
color	White to Almost white
InChI	InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3
InChIKey	OJCLHERKFHHUTB-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCCC(CO)C1
CAS DataBase Reference	116574-71-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36

WGK Germany

HazardClass

IRRITANT

HS Code

29333990

Storage Class

13 - Non Combustible Solids

NFPA 704

	1
2		0

N-Boc-piperidine-3-methanol price More Price(77)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	681318	N-Boc-piperidine-3-methanol 97%	116574-71-1	1g	$31.2	2023-06-20	Buy
Sigma-Aldrich	681318	N-Boc-piperidine-3-methanol 97%	116574-71-1	10g	$297	2023-06-20	Buy
TCI Chemical	B3787	1-(tert-Butoxycarbonyl)-3-piperidinemethanol >95.0%(GC)	116574-71-1	5g	$35	2024-03-01	Buy
TCI Chemical	B3787	1-(tert-Butoxycarbonyl)-3-piperidinemethanol >95.0%(GC)	116574-71-1	25g	$139	2024-03-01	Buy
Usbiological	266687	tert-Butyl 3-(hydroxymethyl)tetrahydro-1(2H)pyridinecarboxylate Asreported	116574-71-1	10g	$375	2026-06-03	Buy

Product number	Packaging	Price	Buy
681318	1g	$31.2	Buy
681318	10g	$297	Buy
B3787	5g	$35	Buy
B3787	25g	$139	Buy
266687	10g	$375	Buy

N-Boc-piperidine-3-methanol Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

(+/-)-1-Boc-3-(hydroxymethyl)piperidine is used as a reactant for synthesis of Pim-1 inhibitors, Vasopressin1b receptor antagonists, CXCR4 antagonists as anti-HIV agents, Amide CCR5 antagonist, PSSRI-based inhibitors of S. aureus multidrug efflux pumps and Human GnRH receptor antagonists.

Uses

Reactant for synthesis of:

Pim-1 inhibitors
Vasopressin1b receptor antagonists
CXCR4 antagonists as anti-HIV agents
Amide CCR5 antagonist
PSSRI-based inhibitors of S. aureus multidrug efflux pumps
Human GnRH receptor antagonists

Synthesis

4606-65-9

24424-99-5

116574-71-1

(1) Preparation of 3-(hydroxymethyl)-1-(tert-butoxycarbonyl)piperidine: To a solution of 3-hydroxymethylpiperidine (1.15 g, 10 mmol) in tetrahydrofuran (15 ml) was added triethylamine (2.8 ml, 20 mmol) at room temperature. Subsequently, a solution of di-tert-butyl dicarbonate (2.62 g, 10 mmol) in tetrahydrofuran (5 ml) was added slowly and dropwise with stirring. The reaction mixture was stirred continuously for 20 hours at room temperature. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate (50 ml), and the organic phase was washed sequentially with water and saturated saline, and then dried with anhydrous sodium sulfate. Finally, the solvent was removed by reduced pressure distillation to afford the target product tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate (2.15 g, 100% yield) as colorless crystals. The product was confirmed by 1H-NMR (CDCl3) and IR (KBr) characterization.1H-NMR (CDCl3) δ: 1.2-1.4 (2H, m), 1.46 (9H, s), 1.5-1.9 (4H, m), 2.8-3.3 (2H, m), 3.51 (2H, t, J = 6.10 Hz), 3.6-3.9 (2H, m) IR (KBr) cm-1: 3491, 1742, 1674, 1428, 1269, 1177, 1153, 858, 769.

References

[1] Patent: US6348468, 2002, B1. Location in patent: Page column 49
[2] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 4, p. 1084 - 1088
[3] Patent: US2004/67935, 2004, A1. Location in patent: Page/Page column 28
[4] Patent: US2002/65265, 2002, A1
[5] Patent: WO2004/72086, 2004, A2. Location in patent: Page 170

N-Boc-piperidine-3-methanol synthesis

Synthesis of N-Boc-piperidine-3-methanol from 3-Piperidinemethanol and Di-tert-butyl dicarbonate and Triethylamine

N-Boc-piperidine-3-methanol Preparation Products And Raw materials

Raw materials

tert-butyl 3-[(phenylamino)methyl]piperidine-1-carboxylate Ethyl nipecotate Methyl N-Boc-piperidine-3-carboxylate Di-tert-butyl dicarbonate 1-Boc-piperidine-3-carboxylic acid

Tetrahydrofuran Norethindrone 3-Piperidinemethanol Triethylamine

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Preparation Products

N-Boc-3,4-dihydro-2H-pyridine

N-Boc-piperidine-3-methanol Suppliers

Global Suppliers ( 314)

Supplier	Tel	Email	Country	ProdList	Advantage
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Shanghai Taijilin Industrial Co., Ltd.	02150630626 17717886015	kate@tajilin.com	China	1340	58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd	3307 18017383231	983544897@qq.com	China	941	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
ITIC MEDCHEM(SUZHOU) CO.,LTD.	0512-68323967 18015559028	sales@iticmedchem.com	China	528	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
Anhui Dexinjia Biopharm Co., Ltd	58
Shanghai Taijilin Industrial Co., Ltd.	58
Anhui Yongsheng Pharmaceutical Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
future industrial shanghai co., ltd	65
ITIC MEDCHEM(SUZHOU) CO.,LTD.	61
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61

View Latest Price from N-Boc-piperidine-3-methanol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	N-Boc-piperidine-3-methanol 116574-71-1		20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.
2023-11-03	Pharmaceutical Intermediates 116574-71-1	$10.00	1kg	99%	100tons	Anhui Zhongda Biotechnology Co., Ltd
2023-06-26	1-Boc-3-piperidinemethanol 116574-71-1	$200.00	10kg	99%	500kg/month	Hebei Mingeng Biotechnology Co., Ltd

N-Boc-piperidine-3-methanol
116574-71-1
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

Pharmaceutical Intermediates
116574-71-1
$10.00
99%
Anhui Zhongda Biotechnology Co., Ltd

1-Boc-3-piperidinemethanol
116574-71-1
$200.00
99%
Hebei Mingeng Biotechnology Co., Ltd

N-Boc-piperidine-3-methanol Spectrum

N-Boc-piperidine-3-methanol(116574-71-1)¹HNMR

116574-71-1 (N-Boc-piperidine-3-methanol) Related Search:

N-Boc-4-piperidinemethanol n-boc-piperidine-2-methanol,1-Boc-Piperidine-2-Methanol N-BOC-piperidine-4-carboxylic acid 1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde N-BOC-3-Aminopiperidine

Ethyl N-Boc-piperidine-2-carboxylate N-Boc-2-piperidinecarboxylic acid Ethyl N-Boc-piperidine-4-carboxylate Ethyl N-BOC-piperidine-2-carboxylate 1-Boc-3-hydroxypiperidine

N-Boc-Piperidine-4-carboxylic acid methyl ester 1-Boc-4-Methylaminopiperidine 1-Boc-3-piperidone N-(tert-Butoxycarbonyl)-4-piperidone tert-Butyl 4-(aminocarbonyl)tetrahydropyridine-1(2H)-carboxylate

(+/-)-1-N-Boc-piperidine-2-carboxamide 1-Boc-3-piperidinecarboxaldehyde 1-N-Boc-piperidine-3-carboxamide

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(+/-)-BOC-3-PIPERIDINE METHANOL N-(TERT-BUTOXYCARBONYL)-3-PIPERIDINEMETHANOL N-BOC-(3S)-PIP(3-CH2OH) N-BOC-3-HYDROXYMETHYLPIPERIDINE (+/-)-N-BOC-3-PIPERIDINE METHANOL N-BOC-3-PIPERIDINYL-METHANOL N-Boc-piperidine-3-methanol TERT-BUTYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE (S)-TERT-BUTYL 3-(HYDROXYMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE (S)-N-(TERT-BUTOXYCARBONYL)-3-HYDROXYMETHYLPIPERIDINE (S)-1-BOC-3-(HYDROXYMETHYL)PIPERIDINE (S)-1-N-BOC-3-HYDROXYMETHYL-PIPERIDINE 1-Boc-3-(hydroxymethyl)pi... 3-(Hydroxymethyl)piperidine, N-BOC protected N-Boc-piperidine-5-Methanol 1-N-Boc-3-(hydroxymethyl)piperidine 1-Boc-3-piperidinemethanol 1-BOC-3-(HYROXYMETHYL)PIPERIDINE 1-TERT-BUTOXYCARBONYL-3-PIPERIDINEMETHANOL, N-BOC-3-PIPERIDINEMETHANOL 1-Piperidinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester N-Boc-piperidine-6-Methanol N-Boc-piperidine-7-Methanol 3-(S)-N-BOC-PIPERIDINE METHANOL 3-HYDROXYMETHYL-1-N-BOC-PIPERIDINE 1-BOC-3-(HYDROXYMETHYL)PIPERIDINE N-Boc-piperidine-8-Methanol 1,1-Dimethylethyl 3-(hydroxymethyl)-1-piperidinecarboxylate 3-(Hydroxymethyl)-N-(tert-butoxycarbonyl)piperidine 1-Boc-3-(hydroxymethyl)piperidine 1-Boc-3-piperidinemethanol 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperidine 1-N-Boc-3-(S)-Methanol-piperidine N-Boc-3-PiperidineMethanol or N-tert-Butyloxycarbonyl-3-piperidineMethanol or N-Boc-3-(hydroxyMethyl)piperidine tert-Btuyl 3-(hydroxymethyl)piperidine-1-carboxylate N-Boc-piperidine-3-methanol N-Boc-piperidine-3-methanol 97% (^+)-1-Boc-3-(hydroxymethyl)piperidine,97% 1-(tert-Butoxycarbonyl)-3-piperidinemethanol > N-Boc-3-piperidinyl alcohol 1-(tert-Butoxycarbonyl)-3-(hydroxymethyl)piperidine 3-(hydroxymethyl)piperidine-1-carboxylate CAS:116574-71-1 N-Boc-3-piperidinecarbinol 3-HYDROXYMETHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER TERT-BUTYL 3-(HYDROXYMETHYL)PIPERIDINE-1-CARBOXYLATE 116574-71-1 116574-71-6 116574-71-5 116574-71-4 116574-71-3 116574-74-1 C11H21NO3 Building Blocks C11 Chemical Synthesis Heterocyclic Building Blocks Piperidines Heterocyclic Compounds pharmacetical Piperidine