2-Methoxy-5-sulfamoylbenzoic acid
- CAS No.
- 22117-85-7
- Chemical Name:
- 2-Methoxy-5-sulfamoylbenzoic acid
- Synonyms
- Sulpride Impurity D;Sulpiride IMpurity D;Sulpiride EP Impurity D;Sulpiride Impurity D(EP);5-SulfaMoyl-o-anisic Acid;5-sulphamoyl-o-anisic acid;Levosulpiride - EP Impurity D;2-Methoxy-5-sulfamoylbenzoicaci;2-METHOXY-5-SULFONYLBENZOIC ACID;2-METHOXY-5-SULFAMOYLBENZOIC ACID
- CBNumber:
- CB7354418
- Molecular Formula:
- C8H9NO5S
- Molecular Weight:
- 231.23
- MDL Number:
- MFCD00129997
- MOL File:
- 22117-85-7.mol
- MSDS File:
- SDS
| Melting point | 220 °C |
|---|---|
| Boiling point | 482.5±55.0 °C(Predicted) |
| Density | 1.492±0.06 g/cm3(Predicted) |
| storage temp. | Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 3.56±0.10(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C8H9NO5S/c1-14-7-3-2-5(15(9,12)13)4-6(7)8(10)11/h2-4H,1H3,(H,10,11)(H2,9,12,13) |
| InChIKey | SQAILWDRVDGLGY-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(S(N)(=O)=O)=CC=C1OC |
| CAS DataBase Reference | 22117-85-7(CAS DataBase Reference) |
| FDA UNII | ZK66UU128U |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2922500090 | |||||||||
| NFPA 704 |
|
2-Methoxy-5-sulfamoylbenzoic acid price More Price(42)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2771 | 2-Methoxy-5-sulfamoylbenzoic Acid | 22117-85-7 | 5G | $54 | 2026-04-30 | Buy |
| TCI Chemical | M2771 | 2-Methoxy-5-sulfamoylbenzoic Acid | 22117-85-7 | 25G | $159 | 2026-04-30 | Buy |
| TRC | TRC-M326640-50G | 2-Methoxy-5-sulfamoylbenzoic Acid | 22117-85-7 | 50g | $508 | 2026-06-03 | Buy |
| TRC | TRC-M326640-1G | 2-Methoxy-5-sulfamoylbenzoic Acid | 22117-85-7 | 1g | $173 | 2026-06-03 | Buy |
| TRC | TRC-M326640-10G | 2-Methoxy-5-sulfamoylbenzoic Acid | 22117-85-7 | 10g | $248 | 2026-06-03 | Buy |
2-Methoxy-5-sulfamoylbenzoic acid Chemical Properties,Uses,Production
Uses
2-Methoxy-5-sulfamoylbenzoic Acid is a metabolite of the antipsychotic drug, Sulpiride (S689145).
Preparation
Synthesis of 2-methoxy-5-sulfamoyl benzoic Acid: In the amination reaction of 2-methoxyl-5-amino-sulfonyl benzoic acid, the main influence factors were mainly ammonia concentration, reaction temperature and reaction time. Firstly, we investigated two approaches of animation reaction: ventilation with ammonia in solvent and ammonium hydroxide as amino-reactant and solvent. In this section, the way of ventilation with ammonia in methyl alcohol and tetrahydrofuran would cause the rapid reaction, resulting to the incomplete reaction of 2-methoxy-5-sulfamoylbenzoic acid owing to the formation of 2-methoxy-5-sulfamoyl benzoic acid coated on the surface of the reaction. On the contrary, the lab test indicated that the way of ammonium hydroxide as amino-reactant and solvent can provide better experimental results. Secondly, the reactive temperature was the more important factor. The optimized amination temperature was to 30 °C. The low temperature would result to the long amination time, whereas high temperature can result to the generation of by-product owing to the hydrolysis of sulfonyl chloride. Finally, we evaluated the effect of reaction time. The optimized reaction time was to 5 hours. The extended reaction time can’t cause the significant improvement of yield. As a consequence, the best reactive temperature was to 30 °C and the best mole ratio between 2-methoxy-5-sulfonylchlorobenzoic acid and ammonium hydroxide was to 1:20 and the best reactive time was to 5 hours. Under the best conditions, the yield can reach to 75.8%.
2-Methoxy-5-sulfamoylbenzoic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| SUZHOU AUSUN CHEMICAL CO., LTD. | 0512-68244182 15850237342 | ausunjoy@163.com | China | 29 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
View Lastest Price from 2-Methoxy-5-sulfamoylbenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-21 | 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
|
$30.00-112.00 | 99.41% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-13 | 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
|
$30.00-112.00 | 99.41% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
- $30.00-112.00
- 99.41%
- TargetMol Chemicals Inc.
-
- 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
- $30.00-112.00
- 99.41%
- TargetMol Chemicals Inc.
-
- 2-Methoxy-5-sulfamoylbenzoic acid
22117-85-7
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
