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Methyl 2-methoxy-5-sulfamoylbenzoate

CAS No.
33045-52-2
Chemical Name:
Methyl 2-methoxy-5-sulfamoylbenzoate
Synonyms
Sulpride Impurity B;Methyl2-Methoxy-5-S;Sulpiride EP Impurity B;Sulpiride Impurity B(EP);Sulpiride impurity B CRS;2-Methoxy-5-sulfamoylbenzoic;methyl 5-sulphamoyl-o-anisate;Sulpiride impurity B (S2192000);Methyl[5-Amino Sulfonyl-2-Methoxy];Methyl 2-Methoxy-5-sulphamoylbenzoa
CBNumber:
CB9455786
Molecular Formula:
C9H11NO5S
Molecular Weight:
245.25
MDL Number:
MFCD01317542
MOL File:
33045-52-2.mol
MSDS File:
SDS
Last updated:2026-06-12 08:45:15

Methyl 2-methoxy-5-sulfamoylbenzoate Properties

Melting point 175-177 °C (lit.)
Boiling point 439.8±55.0 °C(Predicted)
Density 1.360±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka 9.94±0.60(Predicted)
color White to Off-White
InChI InChI=1S/C9H11NO5S/c1-14-8-4-3-6(16(10,12)13)5-7(8)9(11)15-2/h3-5H,1-2H3,(H2,10,12,13)
InChIKey MKDYDRQLKPGNNU-UHFFFAOYSA-N
SMILES C(OC)(=O)C1=CC(S(N)(=O)=O)=CC=C1OC
LogP 0.36
CAS DataBase Reference 33045-52-2(CAS DataBase Reference)
FDA UNII F8XVA6KYT6
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P261-P280
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi
WGK Germany  3
Hazard Note  Irritant
HS Code  2922500090
Storage Class 11 - Combustible Solids
REACH Registrations Active

Methyl 2-methoxy-5-sulfamoylbenzoate price More Price(35)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S2192000 Sulpiride impurity B European Pharmacopoeia (EP) Reference Standard 33045-52-2 10 mg $167 2026-04-30 Buy
Sigma-Aldrich 522279 Methyl 2-methoxy-5-sulfamoylbenzoate 98% 33045-52-2 25g $168 2026-04-30 Buy
Sigma-Aldrich S2192000 Sulpiride impurity B European Pharmacopoeia (EP) Reference Standard 33045-52-2 s2192000 $153 2024-03-01 Buy
TCI Chemical M1942 Methyl 5-(Aminosulfonyl)-2-methoxybenzoate >98.0%(HPLC) 33045-52-2 25g $80 2021-12-16 Buy
Biosynth IA145486 5-(Aminosulfonyl)-2-methoxy-benzoic acid methyl ester 33045-52-2 0.25g $250 2026-06-04 Buy
Product number Packaging Price Buy
S2192000 10 mg $167 Buy
522279 25g $168 Buy
S2192000 s2192000 $153 Buy
M1942 25g $80 Buy
IA145486 0.25g $250 Buy

Methyl 2-methoxy-5-sulfamoylbenzoate Chemical Properties, Uses, Production

Uses

Methyl 2-methoxy-5-sulfamoylbenzoate is a reactant used in the preparation of many pharmaceutical compounds used as anticoagulants, HCV NS5B polymerase inhibitors, therapeutic drugs for treatment of neurodegenerative diseases and oral hypog lycemic agents.

Preparation

Methyl 2-methoxy-5-aminosulfonyl benzoate is an important intermediate for the synthesis of sulpiride, which is the main drug for treatment of psychiatric disorders such as schizophrenia and depression. The synthetic route of methyl 2-methoxy-5-aminosulfonyl benzoate is composed mainly of etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification, which prepared successfully with the help of salicylic acid and methyl salicylate as precursor. The raw materials of the synthetic route are salicylic acid and methyl salicylate, which was synthesized by etherification (phenol hydroxyl), sulfonyl chloride, amination and esterification.
synthesis of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate
synthetic procedure of Methyl 2-Methoxy-5-Aminosulfonyl Benzoate

General Description

Methyl 2-methoxy-5-sulfamoylbenzoate is also referred to as 2-methoxy-5-sulfamoyl methyl benzoate or methyl 5-(aminosulphonyl)-2-methoxybenzoate.

Methyl 2-methoxy-5-sulfamoylbenzoate Preparation Products And Raw materials

Global Suppliers ( 298)
Supplier Tel Email Country ProdList Advantage
SUZHOU AUSUN CHEMICAL CO., LTD. 0512-68244182 15850237342 ausunjoy@163.com China 29 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Beijing Isomersyn Technology CO;LTD 010-82954736 13391601435 sales@isomersyn.com China 3294 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57

View Latest Price from Methyl 2-methoxy-5-sulfamoylbenzoate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Methyl 2-methoxy-5-sulfamoylbenzoate pictures 2026-06-30 Methyl 2-methoxy-5-sulfamoylbenzoate
33045-52-2
1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
Methyl 2-methoxy-5-sulfamoylbenzoate pictures 2026-03-20 Methyl 2-methoxy-5-sulfamoylbenzoate
33045-52-2
$10.00 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
Methyl 2-methoxy-5-sulfamoylbenzoate pictures 2023-09-07 Methyl 2-methoxy-5-sulfamoylbenzoate
33045-52-2
$100.00 1bag 99 5000 Hebei Fengqiang Trading Co., LTD
5-Aminosulfonyl-2-Methoxy-Benzoic Acid Methyl Ester 2-Methoxy-5-Aminosulfonyl Benzoic Acid Methyl Ester Methyl 2-Methoxy-5-Aminosulfonyl Benzoate Methyl 5-(aminosulphonyl)-2-methoxybenzoate METHYL 2-METHOXY-5-SULFAMOYLBENZOATE, 98 % 2-Methoxy-5-sulfamoylbenzoic 2-METHOXY-5-SULFAMIDE METHYL BENZOATE 2-methoxy-5-sulfamoyl methyl benzoate 4-Methoxy-3-(methoxycarbonyl)benzenesulfonamide 2-METHOXY-5-SULFAMOYLBENZOIC ACID METHYL ESTER (33045-52-2) Methyl 2-methoxy-5-sulfamoylbenzoate (CAS NO 33045-52-2) Sulpiride EP Impurity B Sulpride Impurity B Sulpiride Impurity 2(Sulpiride EP Impurity B) Methyl2-Methoxy-5-S Methyl[5-Amino Sulfonyl-2-Methoxy] 5-(Aminosulfonyl)-2-methoxybenzoic Acid Methyl Ester Methyl 2-Methoxy-5-sulfamoylbenzoate 2-Methoxy-5-sulfamoylbenzoic Acid Methyl Ester METHYL-2-METHOXY-5-(AMINOSULPHONYL) BENZOATE(LEVOSULPIRIDE INTERMEDIATES) Sulpiride Impurity B(EP) Benzoic acid,5-(aMinosulfonyl)-2-Methoxy-, Methyl ester 2-METHOXY-5-AMINO SULFONYL BENZOIC ACID METHYL ESTER 2-METHOXY-5-AMINOSULFONYL-METHYL BENZOATE 2-METHOXY-5-SULFAMOYLBENZOIC ACID METHYL ESTER METHYL 2-METHOXY-5-AMINOSULFONYLBENZOATE METHYL 2-METHOXY-5-SULFAMOYLBENZOATE METHYL[5-AMINO SULFONYL-2-METHOXY] BENZOATE methyl 5-sulphamoyl-o-anisate 1-(5,5,7,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)ethanone Methyl5-(Aminosulfonyl)-2-methoxybenzoate> Methyl 2-Methoxy-5-sulphamoylbenzoa Sulpiride impurity B CRS Methyl 2-methoxy-5-sulfamoylbenzoate ISO 9001:2015 REACH Sulpiride impurity B (S2192000) Methyl 2-methoxy-5-sulfamoylbenzoatev Methyl 5-(Aminosulfonyl)-2-methoxybenzoate, ≥ 98.0% Methyl 2-Methoxy-5-sulphamoylbenzoate Methyl 2-Methoxy-5-Sulfamoyibenzaate 2-Methoxy-5-Aminosulfonyl sulfamoylbenzoate Methyl Ester 2--5- 2-Methoxy-5-sulfamoylbenzoyl Benzoic Acid-Methyl ester 33045-52-2 22045-52-2 CH3OC6H3SO2NH2CO2CH3 Building Blocks Organic Building Blocks Sulfonamides/Sulfinamides Sulfur Compounds FINE Chemical & INTERMEDIATES Organic Building Blocks Sulfonamides/Sulfinamides Sulfur Compounds