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4'-tert-Butylacetophenone

4'-tert-Butylacetophenone Structure
4'-tert-Butylacetophenone structure
CAS No.
943-27-1
Chemical Name:
4'-tert-Butylacetophenone
Synonyms
4-TERT-BUTYLACETOPHENONE;NSC 826;PHENOMUSCOL;ASISCHEM D29255;Ebastine Impurity 5;P-T-BUTYLACETOPHENONE;4'-t-Butylacetophenone;Ebastine EP Impurity B;Epastine EP Impurity B;p-tert-Butylacetophenon
CBNumber:
CB3443929
Molecular Formula:
C12H16O
Molecular Weight:
176.25
MDL Number:
MFCD00017256
MOL File:
943-27-1.mol
MSDS File:
SDS
Last updated:2026-05-28 06:32:02
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4'-tert-Butylacetophenone Properties

Melting point 17-18 °C (dimorphic)(lit.)
Boiling point 107-108 °C5 mm Hg(lit.)
Density 0.964 g/mL at 25 °C(lit.)
refractive index n20/D 1.52(lit.)
Flash point 86 °F
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form Liquid
Specific Gravity 0.964
color Clear colorless
Water Solubility insoluble
Cosmetics Ingredients Functions PERFUMING
InChI 1S/C12H16O/c1-9(13)10-5-7-11(8-6-10)12(2,3)4/h5-8H,1-4H3
InChIKey UYFJYGWNYQCHOB-UHFFFAOYSA-N
SMILES CC(=O)c1ccc(cc1)C(C)(C)C
LogP 3.521 (est)
CAS DataBase Reference 943-27-1(CAS DataBase Reference)
FDA UNII JAH8J5D78Y
NIST Chemistry Reference Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]-(943-27-1)
EPA Substance Registry System Ethanone, 1-[4-(1,1-dimethylethyl)phenyl]- (943-27-1)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Flame (GHS02)
GHS02
Signal word  Warning
Hazard statements  H226-H315-H319-H335
Precautionary statements  P241-P242-P261-P264b-P271-P280-P304+P340-P305+P351+P338-P312-P363-P370+P378r-P403+P233-P501c
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  10-36/37/38-20/21/22
Safety Statements  16-29-33-36/37/39-26
RIDADR  UN 1224 3/PG 3
WGK Germany  2
TSCA  TSCA listed
HazardClass  3.2
PackingGroup  III
HS Code  29143990
Storage Class 3 - Flammable liquids
Hazard Classifications Flam. Liq. 3
Limited Quantities 5.0 L (1.3 gallons) (liquid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
2 0

4'-tert-Butylacetophenone price More Price(63)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S552089 4'-(TERT-BUTYL)-ACETOPHENONE AldrichCPR 943-27-1 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 357642 4′-tert-Butylacetophenone 97% 943-27-1 5g $119 2026-04-30 Buy
Sigma-Aldrich S552089 4'-(TERT-BUTYL)-ACETOPHENONE AldrichCPR 943-27-1 250mg $179 2024-03-01 Buy
TCI Chemical B6460 4'-tert-Butylacetophenone min. 95.0 % 943-27-1 5G $61 2026-04-30 Buy
TCI Chemical B6460 4'-tert-Butylacetophenone min. 95.0 % 943-27-1 25G $183 2026-04-30 Buy
Product number Packaging Price Buy
S552089 1 unit $197 Buy
357642 5g $119 Buy
S552089 250mg $179 Buy
B6460 5G $61 Buy
B6460 25G $183 Buy

4'-tert-Butylacetophenone Chemical Properties, Uses, Production

Chemical Properties

clear colorless liquid

Uses

4-tert-Butylacetophenone is an Impurity arising in the synthesis of Ebastine (E320000). Ebastine Impurity B.

Uses

4'-tert-Butylacetophenone is used in the synthesis of 2-pyridone derivatives.

Uses

4′-tert-Butylacetophenone may be used in the synthesis of 2-pyridone derivatives and their fluorescence spectra has been evaluated.

General Description

4′-tert-Butylacetophenone is a para-substituted acetophenone.

Synthesis

p-Tert-butyl acetophenone was prepared as follows: in a 2 ml reaction vial 2-(4-(tert-butyl)phenyl)propan-2-ol (59.4 mg, 0.3 mmol), AgNO3 (1.6 mg, 3 mol%), Bi(OTf)3 (6 mg, 3 mol%) and K2S2O8 (245.8 mg. 3eq), and finally 2 wt% aqueous DAPGS-750-M (0.6 ml, 0.5 M) was added, followed by capping the reaction vial and stirring. After the stirring of the reaction solution, the reaction was extracted three times using ethyl acetate, and the organic phases of several extractions were combined into a 50 mL aubergine flask and processed for about 5 min using a Heidolph rotary evaporator with a rotational speed of 120 rpm, a temperature of 38 C, and a vacuum of 0.1 MPa, followed by column chromatography using a 200-mesh column chromatography silica gel with a unfolding agent of petroleum ether: ethyl acetate = 20: 1 Around, the target compound p-tert-butyl acetophenone was isolated. (42.8 mg, 81% yield, 98% purity by HPLC analysis, from the NMR profile, signal, noise, etc. can also reflect the product purity is very high).

4'-tert-Butylacetophenone synthesis

772-38-3
943-27-1
Synthesis of 4'-tert-Butylacetophenone from 4-(tert-Butyl)phenylacetylene

4'-tert-Butylacetophenone Preparation Products And Raw materials

Raw materials

Mercury, (1,1-dimethylethyl)iodo- Ethyl 3-(4-tert-butylphenyl)propiolate 1-tert-Butyl-4-ethylbenzene 4-tert-Butylphenyl trifluoromethanesulfonate 2-(Vinyloxy)ethyldimethylamine
4-tert-Butylstyrene 4-(tert-Butyl)phenylacetylene 4-tert-Butylphenylboronic acid n-Butyl vinyl ether Acetyl chloride
4'-Chloroacetophenone Acetophenone

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Preparation Products

Musk ketone 4-tert-Butylphenylacetic acid

4'-tert-Butylacetophenone Suppliers

Global Suppliers ( 270)
Supplier Tel Email Country ProdList Advantage
Shandong INOV New Materials Co., Ltd. 18369999171 sales2@promisechemical.com China 85 58
Wuxi Renyi New Materials Technology Co., Ltd 13306222239 wangmeili@renyiam.com China 558 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Beijing HwrkChemical Technology Co., Ltd 89508211 18501085097 sales.bj@hwrkchemical.com China 9407 55
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Shandong INOV New Materials Co., Ltd. 58
Wuxi Renyi New Materials Technology Co., Ltd 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84
Beijing HwrkChemical Technology Co., Ltd 55
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Wuhan Chemwish Technology Co., Ltd 56

View Latest Price from 4'-tert-Butylacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-tert-Butylacetophenone pictures 2026-04-21 4'-tert-Butylacetophenone
943-27-1
 $29.00 99.88% 10g TargetMol Chemicals Inc.
4'-tert-Butylacetophenone pictures 2026-04-21 4'-tert-Butylacetophenone
943-27-1
 $29.00 99.88% 10g TargetMol Chemicals Inc.
4'-tert-Butylacetophenone pictures 2025-12-24 4'-tert-Butylacetophenone
943-27-1
 1KG 99.0% 1000 tons Shaanxi Dideu Medichem Co. Ltd

4'-tert-Butylacetophenone Spectrum

4'-tert-Butylacetophenone(943-27-1)1HNMR4'-tert-Butylacetophenone(943-27-1)Raman4'-tert-Butylacetophenone(943-27-1)FT-IR4'-tert-Butylacetophenone(943-27-1)IR

943-27-1 (4'-tert-Butylacetophenone) Related Search:

Buprofezin 4-tert-Butylbenzoyl chloride 4-tert-Butylcatechol Methyl 4-tert-butylbenzoate 4'-tert-Butyl-4-chlorobutyrophenone
4-tert-Butylphenol Butyl acetate 4'-Hydroxyacetophenone PIPERACETAZINE (250 MG) 4'-Bromoacetophenone
BOURGEONAL 4-Nitroacetophenone 4'-Chloroacetophenone 4-tert-Butylbenzyl chloride Phenylhydrazine
Phenyl valerate 4-tert-Butylbenzyl alcohol 4'-Methoxyacetophenone

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1-[4-(1,1-dimethylethyl)phenyl]-Ethanone 4'-t-Butylacetophenone Acetophenone, 4'-tert-butyl- Ethanone,1-[4-(1,1-dimethylethyl)phenyl]- p-tert-Butylacetophenone 4'-tert-Butylacetophenone,98% PHENOMUSCOL p-tert-Butylacetophenon 4-TERT-BUTYLACETOPHENONE / 4-ISOBUTYL ACETOPHENONE P-T-BUTYLACETOPHENONE 1-[4-(TERT-BUTYL)PHENYL]ETHAN-1-ONE 1-(4-tert-Butylphenyl)ethanone 1-[4-(1,1-dimethylethyl)phenyl]-ethanon p-tert-Butylacetylbenzene Ebastine EP Impurity B Ebastine Impurity 2(EP Impurity B) ASISCHEM D29255 1-(4-tertbutylpheny)ethanone 4''-TERT-BUTYLACETOPHENONE 98% 4-tert-Butylphenyl Methyl Ketone NSC 826 Tert-butyl acetophenone Ebastine IMpurity B (4'-tert-Butylacetophenone) 4'-tert-Butylacetophenone, 97+% 1-((1,1-Dimethylethyl)phenyl)ethanone Acetophenone, 4'-tert-butyl- (8CI) Ethanone, 1-((1,1-dimethylethyl)phenyl)- 1-[4-(1,1-Dimethylethyl)phenyl]etha para-tert-butyl acetophenone Ebastine Impurity 5 Ebastine USP Related Compound B 4'-tert-Butylacetophenone Epastine EP Impurity B Ebastine Impurity 2(Ebastine EP Impurity B) 4''-tert-Butylacetophenone 4′-tert-Butylacetophenone 4′-tert-Butylacetophenone, CAS 943-27-1 1-(4-(tert-Butyl)phenyl)ethanone (Ebastine Impurity) 4-TERT-BUTYLACETOPHENONE 943-27-1 CH33CC6H4COCH3 Organic Building Blocks Ketones Carbonyl Compounds C11 to C12 Building Blocks Building Blocks C11 to C12 Carbonyl Compounds Chemical Synthesis Organic Building Blocks API intermediates C11 to C12 Carbonyl Compounds Ketones Aromatic Acetophenones & Derivatives (substituted) Organics Aromatics, Impurities, Intermediates