Acetamidine hydrochloride
- CAS No.
- 124-42-5
- Chemical Name:
- Acetamidine hydrochloride
- Synonyms
- Acetamidine;ACETAMIDINE HCL;Acetoamidine hydrochloride;ETHANIMIDAMIDE HYDROCHLORIDE;ethanamidine;Acetamine HCl;Acetamidine hydrochl;ACETAMIDINIUM CHLORIDE;ACEDIAMINE HYDROCHLORIDE;Ethylamidinehydrochloride
- CBNumber:
- CB0399289
- Molecular Formula:
- C2H7ClN2
- Molecular Weight:
- 94.54
- MDL Number:
- MFCD00013016
- MOL File:
- 124-42-5.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Acetamidine hydrochloride 95% | 159158 | 100g | $86.9 |
| Acetamidine hydrochloride 95% | 159158 | 500g | $266 |
| Acetamidine Hydrochloride >95.0%(T) | A0008 | 25g | $33 |
| Acetamidine Hydrochloride >95.0%(T) | A0008 | 500g | $159 |
| Acetamidine Hydrochloride | A133070 | 1g | $120 |
| More product size | |||
| Melting point | 165-170 °C(lit.) |
|---|---|
| Boiling point | 129.78°C (rough estimate) |
| Density | 1.0596 (rough estimate) |
| refractive index | 1.5500 (estimate) |
| storage temp. | Inert atmosphere,Room Temperature |
| pka | pK1: 1.60(+1) (25°C) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | White to cream |
| Water Solubility | 1 g/mL |
| Sensitive | Hygroscopic |
| Merck | 14,44 |
| BRN | 3591762 |
| InChI | 1S/C2H6N2.ClH/c1-2(3)4;/h1H3,(H3,3,4);1H |
| InChIKey | WCQOBLXWLRDEQA-UHFFFAOYSA-N |
| SMILES | Cl[H].CC(N)=N |
| CAS DataBase Reference | 124-42-5(CAS DataBase Reference) |
| FDA UNII | M2026K4JCF |
| EPA Substance Registry System | Ethanimidamide, monohydrochloride (124-42-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-36/38 | |||||||||
| Safety Statements | 26-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29252000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Acetamidine hydrochloride price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 159158 | Acetamidine hydrochloride 95% | 124-42-5 | 100g | $86.9 | 2025-07-31 | Buy |
| Sigma-Aldrich | 159158 | Acetamidine hydrochloride 95% | 124-42-5 | 500g | $266 | 2025-07-31 | Buy |
| TCI Chemical | A0008 | Acetamidine Hydrochloride >95.0%(T) | 124-42-5 | 25g | $33 | 2025-07-31 | Buy |
| TCI Chemical | A0008 | Acetamidine Hydrochloride >95.0%(T) | 124-42-5 | 500g | $159 | 2025-07-31 | Buy |
| TRC | A133070 | Acetamidine Hydrochloride | 124-42-5 | 1g | $120 | 2021-12-16 | Buy |
Acetamidine hydrochloride Chemical Properties,Uses,Production
Uses
Acetamidine Hydrochloride is a compound useful in organic synthesis.
Chemical Properties
WHITE FINE CRYSTALLINE POWDER
Uses
Acetamidine hydrochloride was used in the preparation of decarboxyectoine. It was also used in the synthesis of ethyl 4-(4-hydroxyphenyl)methylidene-2-methyl-5-oxo-1-imidazolacetate.
Application
Acetamidine hydrochloride can be used as an organic synthesis reactant for the preparation of other compounds such as 2-aminopyridine derivatives. Nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride can be used to synthesise 2-aminopyridine derivatives under catalyst-free conditions[1]. This amination reaction has the advantages of high yield, high chemoselectivity and wide substrate adaptability using acetamidine hydrochloride as the ammonia source. In addition, an efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride produces primary amines[2].
General Description
Acetamidine hydrochloride is an amidine salt and its conversion to 2,4,6-trimethyl-sym-triazine has been studied.
Purification Methods
The hydrochlorde can be recrystallised from small volumes of EtOH. Alternatively it is dissolved in EtOH, filtered, Et2O is added; filter the crystalline salt off under N2 and dry it in a vacuum desiccator over H2SO4. The salt is deliquescent and should be stored in a tightly stoppered container. Its solubility in H2O is 10% at room temperature and it is soluble in Me2CO. The free base reacts strongly alkaline in H2O. It has max 224nm ( 4000) in H2O. The picrate has m 252o (sintering at ~245o). [Dox Org Synth Coll Vol I 5 1941, Davies & Parsons Chem Ind (London) 628 1958, Barnes et al. J Am Chem Soc 62 1286 1940 give m 177-178o, Beilstein 2 H 185, 2 I 85, 2 II 183, 2 III 416, 2 IV 428.]
References
[1] YIBIAO LI . Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride1[J]. Organic & Biomolecular Chemistry, 2018, 16 41: Pages 7564-7567. DOI:10.1039/c8ob02129e.
[2] XUE HUANG. A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines[J]. Journal of Chemical Research-s, 2017, 46 1: 315-320. DOI:10.3184/174751917X14931195075580.
Acetamidine hydrochloride Preparation Products And Raw materials
Raw materials
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Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Hefei Lbao Physical & Chemical Science Co.,Ltd | +1-5184799099 | lbaochemicals@gmail.com | China | 674 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21597 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29831 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 904 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6369 | 58 |
View Lastest Price from Acetamidine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-02-15 | Acetamidine hydrochloride
124-42-5
|
US $0.00 / kg | 1kg | 98% | Customise | Hefei Lbao Physical & Chemical Science Co.,Ltd | |
 |
2026-02-11 | Acetamidine hydrochloride
124-42-5
|
US $99.00-80.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-02-09 | Acetamidine hydrochloride
124-42-5
|
US $0.00 / kg | 1kg | 99 | 1 | Hangzhou Lucky Biology Co., Ltd |
-
- Acetamidine hydrochloride
124-42-5
- US $0.00 / kg
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- Acetamidine hydrochloride
124-42-5
- US $99.00-80.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Acetamidine hydrochloride
124-42-5
- US $0.00 / kg
- 99
- Hangzhou Lucky Biology Co., Ltd
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