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Acetamidine hydrochloride

Acetamidine hydrochloride Structure
Acetamidine hydrochloride structure
CAS No.
124-42-5
Chemical Name:
Acetamidine hydrochloride
Synonyms
Acetamidine;ACETAMIDINE HCL;Acetoamidine hydrochloride;ETHANIMIDAMIDE HYDROCHLORIDE;ACETAMIDINIUM CHLORIDE;ethanamidine;Acetamine HCl;Acetamidine hydrochl;ACEDIAMINE HYDROCHLORIDE;ACETAMIDINE HYDROCHLORIDE
CBNumber:
CB0399289
Molecular Formula:
C2H7ClN2
Molecular Weight:
94.54
MDL Number:
MFCD00013016
MOL File:
124-42-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-25 18:04:04
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Acetamidine hydrochloride Properties

Melting point 165-170 °C(lit.)
Boiling point 129.78°C (rough estimate)
Density 1.0596 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Inert atmosphere,Room Temperature
pka pK1: 1.60(+1) (25°C)
form Crystalline Powder, Crystals and/or Chunks
color White to cream
Water Solubility 1 g/mL
Sensitive Hygroscopic
Merck 14,44
BRN 3591762
InChI 1S/C2H6N2.ClH/c1-2(3)4;/h1H3,(H3,3,4);1H
InChIKey WCQOBLXWLRDEQA-UHFFFAOYSA-N
SMILES Cl[H].CC(N)=N
CAS DataBase Reference 124-42-5(CAS DataBase Reference)
FDA UNII M2026K4JCF
EPA Substance Registry System Ethanimidamide, monohydrochloride (124-42-5)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi
Risk Statements  36/37/38-36/38
Safety Statements  26-37/39
WGK Germany  3
F  3
TSCA  TSCA listed
HS Code  29252000
Storage Class 11 - Combustible Solids
NFPA 704
0
2 0

Acetamidine hydrochloride price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 159158 Acetamidine hydrochloride 95% 124-42-5 100g $92.5 2026-04-30 Buy
Sigma-Aldrich 159158 Acetamidine hydrochloride 95% 124-42-5 500g $298 2026-04-30 Buy
TCI Chemical A0008 Acetamidine Hydrochloride >95.0%(T) 124-42-5 25g $21 2026-04-30 Buy
TCI Chemical A0008 Acetamidine Hydrochloride >95.0%(T) 124-42-5 500g $117 2026-04-30 Buy
Usbiological 258357 Acetamine HCl Asreported 124-42-5 250g $360 2026-06-03 Buy
Product number Packaging Price Buy
159158 100g $92.5 Buy
159158 500g $298 Buy
A0008 25g $21 Buy
A0008 500g $117 Buy
258357 250g $360 Buy

Acetamidine hydrochloride Chemical Properties, Uses, Production

Uses

Acetamidine Hydrochloride is a compound useful in organic synthesis.

Chemical Properties

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Uses

Acetamidine hydrochloride was used in the preparation of decarboxyectoine. It was also used in the synthesis of ethyl 4-(4-hydroxyphenyl)methylidene-2-methyl-5-oxo-1-imidazolacetate.

Application

Acetamidine hydrochloride can be used as an organic synthesis reactant for the preparation of other compounds such as 2-aminopyridine derivatives. Nucleophilic substitution and hydrolysis of 2-fluoropyridine and acetamidine hydrochloride can be used to synthesise 2-aminopyridine derivatives under catalyst-free conditions[1]. This amination reaction has the advantages of high yield, high chemoselectivity and wide substrate adaptability using acetamidine hydrochloride as the ammonia source. In addition, an efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride produces primary amines[2].

General Description

Acetamidine hydrochloride is an amidine salt and its conversion to 2,4,6-trimethyl-sym-triazine has been studied.

Purification Methods

The hydrochlorde can be recrystallised from small volumes of EtOH. Alternatively it is dissolved in EtOH, filtered, Et2O is added; filter the crystalline salt off under N2 and dry it in a vacuum desiccator over H2SO4. The salt is deliquescent and should be stored in a tightly stoppered container. Its solubility in H2O is 10% at room temperature and it is soluble in Me2CO. The free base reacts strongly alkaline in H2O. It has max 224nm ( 4000) in H2O. The picrate has m 252o (sintering at ~245o). [Dox Org Synth Coll Vol I 5 1941, Davies & Parsons Chem Ind (London) 628 1958, Barnes et al. J Am Chem Soc 62 1286 1940 give m 177-178o, Beilstein 2 H 185, 2 I 85, 2 II 183, 2 III 416, 2 IV 428.]

References

[1] YIBIAO LI . Transition-metal-free access to 2-aminopyridine derivatives from 2-fluoropyridine and acetamidine hydrochloride1[J]. Organic & Biomolecular Chemistry, 2018, 16 41: Pages 7564-7567. DOI:10.1039/c8ob02129e.
[2] XUE HUANG. A highly efficient heterogeneous copper-catalysed cascade reaction of aryl iodides with acetamidine hydrochloride leading to primary arylamines[J]. Journal of Chemical Research-s, 2017, 46 1: 315-320. DOI:10.3184/174751917X14931195075580.

Acetamidine hydrochloride synthesis

75-05-8
124-42-5
Synthesis of Acetamidine hydrochloride from Acetonitrile

Acetamidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethyl methyl ether Acetonitrile Phosphoric acid Imine Chlorosulfonic acid
Hydrogen chloride methanol solution Ammonium chloride Hydrochloric acid Methanol Ammonia
ethyl acetimidate N'-Hydroxyethanimidamide hydrochloride

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Preparation Products

5-Acetamidomethyl-4-Amino-2-Methyl pyrimidine 2,4-Dimethyl-pyrimidine-5-carboxylic acid Acetamiprid Thiamine nitrate 5-Bromo-4-hydroxy-2-methylpyrimidine
4-Hydroxy-2-methylpyrimidine 4-Amino-2-methylpyrimidine-5-carbonitrile 4-(Trifluoromethyl)-2-methylpyrimidine-5-carboxylic acid Phosazetim 4-Amino-5-aminomethyl-2-methylpyrimidine
4-Amino-2-methyl-pyrimidine-5-carboxylic acid 4-Chloro-2-methylpyrimidine 4(1H)-Pyrimidinone, 2-methyl- (8CI,9CI) 4,6-Dihydroxy-2-methyl-pyrimidine-5-carbaldehyde 4,6-Dihydroxy-2-methylpyrimidine
Thiamine hydrochloride 4-Hydroxy-2-methyl-pyrimidine-5-carboxylic acid ethyl ester 4-Hydroxy-2-methyl-6-trifluoromethylpyrimidine

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Acetamidine hydrochloride Suppliers

Global Suppliers ( 449)
Supplier Tel Email Country ProdList Advantage
Zibo Run Hang Seng material Technology Co., LTD 13561657928 13561657928 2388773670@qq.com China 293 58
Beijing Ouhe Technology Co., Ltd 13552068683 13522913783 2355560935@qq.com China 11777 60
Shandong Xibang Biological Technology Development Co. LTD 0536-3611186 15063661551 196056703@qq.com China 58 58
Shandong Xinhua Pharmceutical Co.,LTD 0533- 2196801 yaojianyong@xhzy.com China 70 60
Qingdao Ruifengyuan Chemical Co., Ltd. 15069072278 qd-ruifengyuan@qq.com China 184 58
Shanghai Shenju Chemical Co., LTD 13167128868 13661427209 3936696707@qq.com China 10000 58
Dalian Rongju International Trade Co., Ltd. 13478634573 13478634573 106046253@qq.com China 50 58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. 21-54820552 17702105771 188738128@qq.com China 300 66
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Supplier Advantage
Zibo Run Hang Seng material Technology Co., LTD 58
Beijing Ouhe Technology Co., Ltd 60
Shandong Xibang Biological Technology Development Co. LTD 58
Shandong Xinhua Pharmceutical Co.,LTD 60
Qingdao Ruifengyuan Chemical Co., Ltd. 58
Shanghai Shenju Chemical Co., LTD 58
Dalian Rongju International Trade Co., Ltd. 58
Shanghai Chemical Pharm-Intermediate Tech.Co., Ltd. 66
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62

View Latest Price from Acetamidine hydrochloride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Acetamidine hydrochloride pictures 2026-09-15 Acetamidine hydrochloride
124-42-5
 $80.00-99.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Acetamidine hydrochloride pictures 2026-09-11 Acetamidine hydrochloride
124-42-5
 1kg 99 1 Hangzhou Lucky Biology Co., Ltd
Acetamidine hydrochloride pictures 2026-06-30 Acetamidine hydrochloride
124-42-5
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd

Acetamidine hydrochloride Spectrum

Acetamidine hydrochloride(124-42-5)MSAcetamidine hydrochloride(124-42-5)1HNMRAcetamidine hydrochloride(124-42-5)13CNMRAcetamidine hydrochloride(124-42-5)IR1Acetamidine hydrochloride(124-42-5)IR2Acetamidine hydrochloride(124-42-5)Raman

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ACEDIAMINE HYDROCHLORIDE Ethaneamidinehydrochloride ethanimidamide,monohydrochloride Ethylamidinehydrochloride Acetalmidine hydrochioride ACECAMIDINE HYDROCHLORIDE Acetamidine hydrochloride, 98+% ETHENYLAMIDINE HYDROCHLORIDE ETHANAMIDINE HYDROCHLORIDE A-AMINO-A-IMINOETHANE HYDROCHLORIDE ACETAMIDINE HYDROCHLORIDE ethanamidine Acetoamidine hydrochloride Acetamidine hydrochloride,95% Acetamidine hydrochloride ,97% Acetamidine hydrochl Methylamidine hydrochloride Acetamine HCl EthaniMidaMide, hydrochloride (1:1) AcetaMidine hydrochloride, 98+% 100GR AcetaMidine Hydrochloride , 95.0%(T) AcetaMidine hydrochloride 95% Acetamidine Hydrochloride > Acetamidine hydrochloride 13C 13C]-Acetamidine hydrochloride salt Inorganic Chemicals, Inorganic Salts ACETAMIDINIUM CHLORIDE Acetamidine ACETAMIDINE HCL ETHANIMIDAMIDE HYDROCHLORIDE Acetamidine monohydrochloride 124-42-5 C2H7CIN2 C2H6N2 C2H7ClN2 CH3CNHNH2HCl CH3CNHNH2 C2H6N2HCl C2H6N2ClH Organic Building Blocks Imines/Amidines Nitrogen Compounds Building Blocks straight chain compounds Miscellaneous Reagents Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives pharmacetical Aliphatics Imines/Amidines Nitrogen Compounds Organic Building Blocks Pharmaceutical Intermediates 124-42-5