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(R)-(-)-Nipecotic acid

(R)-(-)-Nipecotic acid structure

CAS No.: 25137-00-2

Chemical Name:: (R)-(-)-Nipecotic acid

Synonyms: (R)-(-)-Nipecotic ac;(R)-(-)-Nipecotic acid;Ethyl (R)-nipecotate, 95+%;(R)-(-)-NIPECOTIC ACID 97%;(R)-(-)-NIPECOTIC ACID HCL;D-Piperidine-3-carboxylic acid;(3R)-(-)-Piperidine-3-carboxyL;3-Piperidinecarboxylic acid, (R)-;R-(-)-Piperidine-3-carboxylic acid;(3R)-Piperidine-3α-carboxylic acid

CBNumber:: CB7362361

Molecular Formula:: C6H11NO2

Molecular Weight:: 129.16

MDL Number:: MFCD01630787

MOL File:: 25137-00-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:39:22

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(R)-(-)-Nipecotic acid Properties

Melting point	251-255 °C
alpha	-5 º (c=1, H2O)
Boiling point	265.8±33.0 °C(Predicted)
Density	1.02g/cm
refractive index	-4.5 ° (C=5, H2O)
RTECS	TM6125390
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	Methanol (Very Slightly), Water (Sparingly)
pka	3.88±0.20(Predicted)
form	Solid
color	White to Beige
optical activity	[α]22/D 5°, c = 1 in H2O
Major Application	peptide synthesis
InChI	1S/C6H11NO2/c8-6(9)5-2-1-3-7-4-5/h5,7H,1-4H2,(H,8,9)/t5-/m1/s1
InChIKey	XJLSEXAGTJCILF-RXMQYKEDSA-N
SMILES	OC(=O)[C@@H]1CCCNC1
CAS DataBase Reference	25137-00-2(CAS DataBase Reference)
FDA UNII	J4Z8PAL7EZ
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi,Xn

Risk Statements

36/37/38-22

Safety Statements

26-36

WGK Germany

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

(R)-(-)-Nipecotic acid price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	656356	(R)-(–)-3-Piperidinecarboxylic acid 97%	25137-00-2	10g	$399	2026-04-30	Buy
Sigma-Aldrich	656356	(R)-(–)-3-Piperidinecarboxylic acid 97%	25137-00-2	1g	$41.1	2023-06-20	Buy
TCI Chemical	N0654	(R)-(-)-3-Piperidinecarboxylic Acid >98.0%(T)	25137-00-2	1g	$33	2026-04-30	Buy
TCI Chemical	N0654	(R)-(-)-3-Piperidinecarboxylic Acid >98.0%(T)	25137-00-2	5g	$91	2026-04-30	Buy
Usbiological	285855	(R)-(-)-nipecotic acid Asreported	25137-00-2	2g	$333	2026-06-03	Buy

Product number	Packaging	Price	Buy
656356	10g	$399	Buy
656356	1g	$41.1	Buy
N0654	1g	$33	Buy
N0654	5g	$91	Buy
285855	2g	$333	Buy

(R)-(-)-Nipecotic acid Chemical Properties, Uses, Production

Chemical Properties

White solid

Uses

peptide synthesis

Definition

ChEBI: (R)-nipecotic acid is the (R)-enantiopmer of nipecotic acid. It is an enantiomer of a (S)-nipecotic acid. It is a tautomer of a (R)-nipecotic acid zwitterion.

General Description

(R)-(-)-3-Piperidinecarboxylic acid is an inhibitor of GABA (γ-aminobutyric acid) uptake.

Synthesis

4138-26-5

88495-55-0

498-95-3

The general procedure for the synthesis of (S)-piperidine-3-carboxamide and 3-piperidinecarboxylic acid from 3-piperidinecarboxamide is as follows: Example 3: Selective hydrolysis of the R-enantiomer of racemic 3-piperidinecarboxamide in Cupriavidus sp. strain KNK-J915 (FERM BP-10739). Bacterial cell suspensions were prepared by culturing strain KNK-J915 as in Example 1. 0.1 mL of bacterial cell suspension was mixed with 100 mM phosphate buffer (0.1 mL, pH 7.0) containing 1.0-5.0% racemic 3-piperidinecarboxamide and the mixture was reacted by shaking at 30°C for 35 hours. Upon completion of the reaction, solids such as bacterial cells were removed by centrifugation. Subsequently, the substrates and products in the reaction mixture were derivatized by reaction with benzyl chlorocarbonate. The resulting derivatives were analyzed by high performance liquid chromatography (HPLC) to determine conversion (percentage) and optical purity (ee percentage). The results are listed in Table 3. HPLC analysis conditions: - Conversion rate analyzing column: YMC-A303 (4.6 mm × 250 mm, manufactured by YMC Inc.), eluent: 20 mM aqueous phosphoric acid (pH 2.5)/acetonitrile = 7/3, flow rate: 1.0 mL/min, column temperature: 35 °C, detection wavelength: 210 nm. - Optical purity analysis column: CHIRALPAK AD-RH (4.6 mm × 150 mm, manufactured by Daicel Chemical Industries, Ltd.), eluent: 20 mM phosphate buffer (pH 2.5)/acetonitrile = 7/3, flow rate: 0.5 mL/min, column temperature: room temperature, detection wavelength: 210 nm.

References

[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 15

(R)-(-)-Nipecotic acid Preparation Products And Raw materials

Raw materials

Nipecotamide

Preparation Products

(R)-(-)-Nipecotic acid Suppliers

Global Suppliers ( 220)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56
TCI (Shanghai) Development Co., Ltd.	81
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60

View Latest Price from (R)-(-)-Nipecotic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-06-27	(R)-(-)-Nipecotic acid 25137-00-2		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd
2021-07-02	(R)-(-)-Nipecotic acid 25137-00-2	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	(R)-(-)-Nipecotic acid 25137-00-2	$1.00	1KG	98%	1kg,5kg,100kg	Career Henan Chemical Co

(R)-(-)-Nipecotic acid
25137-00-2
$0.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

(R)-(-)-Nipecotic acid
25137-00-2
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(R)-(-)-Nipecotic acid
25137-00-2
$1.00
98%
Career Henan Chemical Co

(R)-(-)-Nipecotic acid Spectrum

(R)-(-)-Nipecotic acid(25137-00-2)¹HNMR

25137-00-2 ((R)-(-)-Nipecotic acid) Related Search:

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(R)-(-)-NIPECOTIC ACID HCL (R)-(-)-Nipecotic acid, (3R)-(-)-3-Carboxypiperidine (R)-(-)-3-Piperidinecarboxylic acid 97% Ethyl (R)-nipecotate, 95+% (R)-(-)-3-Piperidinecarboxylic acid (R)-(-)-3-PIPERIDINECARBOXYLIC ACID HYDROCHLORIDE (R)-PIPERIDINE-3-CARBOXYLIC ACID HCL (R)-(-)-PIPERIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE (R)-(-)-NIPECOTIC ACID HYDROCHLORIDE (R)-3-Piperidine-3-Carboxylic Acid HCl D-Piperidine-3-carboxylic acid R-(-)-Piperidine-3-carboxylic acid (R)-(-)-NIPECOTIC ACID 97% (R)-(-)-Nipecotic acid (3R)-Piperidine-3α-carboxylic acid (R)-(-)-Nipecotic ac (R)-(-)-3-PiperidinecarboxylicAcid> (3R)-(-)-Piperidine-3-carboxyL 3-Piperidinecarboxylic acid, (3R)- 3-Piperidinecarboxylic acid, (R)- R-(-)-PIPERIDINE-3-CARBOXYLIC ACID 98%BATCH NO# AO/RNA/008/23 R-(-)-PIPERIDINE-3-CARBOXYLIC ACID 98% NITROGEN(R-(-)PIPERIDINE-3-CARBOXYLIC) (R)-(–)-3-Piperidinecarboxylic acid, 98% (R)-Piperidine-3-carboxylic acid - [P12310] 25137-00-2 C8H11N2 Chiral Building Blocks Asymmetric Synthesis Piperidines Heterocyclic Building Blocks Carboxylic Acids (Chiral) Chiral Building Blocks Synthetic Organic Chemistry Chiral Reagent Piperidine Piperidine Series Nitrogen cyclic compounds Beta amino acids