SB 218795
- CAS No.
- 174635-53-1
- Chemical Name:
- SB 218795
- Synonyms
- T23316;SB 218795;Sb 218795r;SB 218795, 10 mM in DMSO;Methyl (R)-2-phenyl-2-(2-phenylquinoline-4-carboxamido)acetate;methyl (2R)-2-phenyl-2-[(2-phenylquinoline-4-carbonyl)amino]acetate;(-)-(R)-N-(α-Methoxycarbonylbenzyl)-2-phenylquinoline-4-carboxamide;(-)-(R)-N-(ALPHA-METHOXYCARBONYLBENZYL)-2-PHENYLQUINOLINE-4-CARBOXAMIDE;(R)-[[(2-PHENYL-4-QUINOLINYL)CARBONYL]AMINO]-METHYL ESTER BENZENEACETIC ACID;Benzeneacetic acid, α-[[(2-phenyl-4-quinolinyl)carbonyl]amino]-, methyl ester, (αR)-
- CBNumber:
- CB7376630
- Molecular Formula:
- C25H20N2O3
- Molecular Weight:
- 396.44
- MDL Number:
- MFCD00951240
- MOL File:
- 174635-53-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SB 218795 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 42373 | SB-218795 ≥98% | 174635-53-1 | 5mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 42373 | SB-218795 ≥98% | 174635-53-1 | 10mg | $186 | 2026-04-30 | Buy |
| Cayman Chemical | 42373 | SB-218795 ≥98% | 174635-53-1 | 25mg | $416 | 2026-04-30 | Buy |
| ChemScene | CS-0029222 | SB 218795 99.86% | 174635-53-1 | 5mg | $141 | 2026-06-04 | Buy |
| ChemScene | CS-0029222 | SB 218795 99.86% | 174635-53-1 | 10mg | $227 | 2026-06-04 | Buy |
SB 218795 Chemical Properties, Uses, Production
Uses
SB 218795 is an NK3 receptor antagonist.
Definition
ChEBI: (2R)-2-[[oxo-(2-phenyl-4-quinolinyl)methyl]amino]-2-phenylacetic acid methyl ester is a member of quinolines.
Biological Activity
Potent, selective and competitive non-peptide NK 3 receptor antagonist (K i = 13 nM at hNK 3 ). Displays 90-fold and 7000-fold selectivity over hNK 2 and hNK 1 receptors respectively. Active in vivo , inhibiting agonist-induced pupillary constriction.
in vivo
SB 218795 (0.25-1 mg/kg; i.v.) inhibits Senktide-induced miosis in rabbits by the maximum inhibition of 78%[2].
IC 50
hNK3: 13 nM (Ki); hNK2: 1220 nM (Ki)
SB 218795 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 218795 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Shanghai Han-Xiang Chemical Co., Ltd. | 17754423994 | candy@biochempartner.com | China | 3057 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Dongyang Biotechnology Co., Ltd. | 0512-13601744364 13601744364 | chemsharker@126.com | China | 1161 | 58 |
