Acetylsalicylsalicylic acid
- CAS No.
- 530-75-6
- Chemical Name:
- Acetylsalicylsalicylic acid
- Synonyms
- DIPLOSALSALATE;2-[[2-(Acetyloxy)benzoyl]oxy]benzoic acid;2-(Ace;Acesalum;Diplosalacetat;Diplosal Acetate;Aspirin IMpurity D;Aspirin Impurity 4;Aspirin EP IMpurity D;Carbasalate EP Impurity B
- CBNumber:
- CB7385272
- Molecular Formula:
- C16H12O6
- Molecular Weight:
- 300.26
- MDL Number:
- MFCD00143537
- MOL File:
- 530-75-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 153-160 °C |
|---|---|
| Boiling point | 361.5°C (rough estimate) |
| Density | 1.346 |
| refractive index | 1.4600 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Sparingly), DMSO (Sparingly), Methanol (Slightly) |
| pka | 2.94±0.36(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 20mg/L(21 ºC) |
| Major Application | pharmaceutical (small molecule) |
| InChI | InChI=1S/C16H12O6/c1-10(17)21-14-9-5-3-7-12(14)16(20)22-13-8-4-2-6-11(13)15(18)19/h2-9H,1H3,(H,18,19) |
| InChIKey | DDSFKIFGAPZBSR-UHFFFAOYSA-N |
| SMILES | C(OC1=CC=CC=C1C(O)=O)(=O)C1=CC=CC=C1OC(C)=O |
| FDA UNII | VBE72MCP5L |
| EPA Substance Registry System | 2-Carboxyphenyl 2-(acetyloxy)benzoate (530-75-6) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H335-H319-H315 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29182900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Acetylsalicylsalicylic acid price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001161 | Carbasalate impurity B European Pharmacopoeia (EP) Reference Standard | 530-75-6 | 5 mg | $127 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1940 | Carbasalate impurity B | 530-75-6 | 50mg | $793 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001161 | Carbasalate impurity B European Pharmacopoeia (EP) Reference Standard | 530-75-6 | y0001161 | $150 | 2024-03-01 | Buy |
| Matrix Scientific | 297098 | 2-((2-Acetoxybenzoyl)oxy)benzoic acid | 530-75-6 | 250.00mg | $49 | 2026-05-19 | Buy |
| Matrix Scientific | 297098 | 2-((2-Acetoxybenzoyl)oxy)benzoic acid | 530-75-6 | 1.00g | $91 | 2026-05-19 | Buy |
Acetylsalicylsalicylic acid Chemical Properties, Uses, Production
Chemical Properties
white to almost white fine crystalline powder
Uses
Antiinflammatory;Cyclooxygenase inhibitor
Uses
analgesic, antipyretic
Uses
Acetylsalicylic Acid Impurity C
Definition
ChEBI: 2-[(2-acetyloxyphenyl)-oxomethoxy]benzoic acid is a carbonyl compound.
Synthesis
552-94-3
108-24-7
530-75-6
To a solution of 2-((2-hydroxybenzoyl)oxy)benzoic acid (5.0 g, 19.37 mmol) in ethanoic anhydride (15.0 mL, 147.0 mmol) was added 3 drops of concentrated hydrochloric acid. The reaction mixture was stirred at room temperature for 16-20 hours. After completion of the reaction, the mixture was diluted with ice-cold water (50 mL) and the precipitated solid was collected by filtration. The solid was washed sequentially with water (2 x 10 mL) and hexane (20 mL) and dried to give 2-((2-acetoxybenzoyl)oxy)benzoic acid (5.5 g) as a white solid. Thin layer chromatography (TLC) Rf value was 0.3 (unfolding agent: 50% ethyl acetate/hexane).
Purification Methods
Crystallise the analgesic from dilute AcOH or EtOH (m 161-162o), MeOH (m 165-168o), and *C6H6/EtOH (m 163-165o). Its solubilities in boiling Et2O, *C6H6 and EtOH are 1.4%, 2.2% and 33%, respectively. [Baker et al. J Chem Soc 201 1951, Garrett et al. J Am Pharm Soc 48 684 1959, Beilstein 10 I 41, 10 II 54, 10 IV 165.]
References
[1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 5, p. 2158 - 2161
[2] Patent: US2014/357680, 2014, A1. Location in patent: Paragraph 0135-0136
[3] Patent: WO2014/195961, 2014, A1. Location in patent: Paragraph 00125; 00126
Acetylsalicylsalicylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| UHN Shanghai Research & Development Co., Ltd. | 021-58958002 18930822973 | sales@uhnshanghai.com | China | 997 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| HANSHANG CHEMICAL SCIENTIFIC LIMITED | 021-50521775 15800962688 | sales@hanshangchem.com | China | 471 | 57 |
| S.Z. PhyStandard Bio-Tech. Co., Ltd. | 0755-83725681-603 | China | 4484 | 50 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
View Latest Price from Acetylsalicylsalicylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-02 | ACETYLSALICYLSALICYLIC ACID
530-75-6
|
$7.00 | 1KG | 99% | Career Henan Chemical Co |
-
- ACETYLSALICYLSALICYLIC ACID
530-75-6
- $7.00
- 99%
- Career Henan Chemical Co
