4-Amino-N-methylphthalimide

4-Amino-N-methylphthalimide Properties

Melting point	246-248 °C(lit.)
Boiling point	368.3±25.0 °C(Predicted)
Density	1.411±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	-0.27±0.20(Predicted)
Appearance	Light yellow to yellow Solid
InChI	1S/C9H8N2O2/c1-11-8(12)6-3-2-5(10)4-7(6)9(11)13/h2-4H,10H2,1H3
InChIKey	KMEBUNSLFRQSEM-UHFFFAOYSA-N
SMILES	CN1C(=O)c2ccc(N)cc2C1=O
CAS DataBase Reference	2307-00-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Xi

Risk Statements

36/37/38

Safety Statements

26-37/39

WGK Germany

3

HS Code

29251900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

NFPA 704

	0
2		0

4-Amino-N-methylphthalimide price More Price(48)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	247715	4-Amino-N-methylphthalimide 97%	2307-00-8	1g	$151	2023-06-20	Buy
TCI Chemical	A1561	4-Amino-N-methylphthalimide >98.0%(HPLC)(N)	2307-00-8	5g	$30	2026-04-30	Buy
TCI Chemical	A1561	4-Amino-N-methylphthalimide >98.0%(HPLC)(N)	2307-00-8	25g	$97	2026-04-30	Buy
Biosynth	CAA30700	4-Amino-N-methylphthalimide	2307-00-8	10g	$354	2026-06-04	Buy
Biosynth	CAA30700	4-Amino-N-methylphthalimide	2307-00-8	100g	$1180	2026-06-04	Buy

Product number	Packaging	Price	Buy
247715	1g	$151	Buy
A1561	5g	$30	Buy
A1561	25g	$97	Buy
CAA30700	10g	$354	Buy
CAA30700	100g	$1180	Buy

4-Amino-N-methylphthalimide Chemical Properties,Uses,Production

Uses

The intermediate charge-transfer transients of 4-amino-N-methylphthalimide (4AMP) has been characterized by laser flash photolysis, steady-state and time-resolved fluorescence studies. 4AMP is a solvatochromic fluorescent dye. Transient solvation of 4AMP in binary supercritical fluids composed of 2-propanol and CO₂ has been studied by frequency-domain fluorescence spectroscopy.

General Description

The intermediate charge-transfer transients of 4-amino-N-methylphthalimide (4AMP) has been characterized by laser flash photolysis, steady-state and time-resolved fluorescence studies. 4AMP is a solvatochromic fluorescent dye. Transient solvation of 4AMP in binary supercritical fluids composed of 2-propanol and CO₂ has been studied by frequency-domain fluorescence spectroscopy.

Synthesis

3676-85-5

74-88-4

2307-00-8

GENERAL STEPS: Potassium hydroxide (0.35 g, 6.17 mmol) was added to a solution of 4-amino-phthalimide (1.00 g, 6.17 mmol) in dimethylformamide (30 mL) and the reaction mixture was stirred at room temperature for 2 hours. Subsequently, iodomethane (0.88 g, 6.17 mmol) was added and stirring was continued at the same temperature for 18 hours. Upon completion of the reaction, water (50 mL) and ethyl acetate (50 mL) were added for extraction and the organic phase was separated. The organic phase was washed sequentially with saturated saline, dried with anhydrous sodium sulfate and concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography (elution gradient: 0-100% cyclohexane solution of ethyl acetate) to afford N-methyl-4-amino phthalimide as a yellow solid (1.00 g, 92% yield). The product was characterized as follows: 1H NMR (DMSO-d6) δ 7.46 (d, J = 8.24 Hz, 1H), 6.90 (d, J = 2.00 Hz, 1H), 6.77 (dd, J = 8.24, 2.00 Hz, 1H), 6.42 (br.s, 2H), 2.94 (s, 3H); 13C NMR (DMSO-d6) δ 168.87, 168.57, 155.27, 135.10, 125.17, 117.33, 116.84, 107.42, 23.83; MS (m/z): 177 [M + H]+.

References

[1] Molecules, 2017, vol. 22, # 9,

4-Amino-N-methylphthalimide synthesis

Synthesis of 4-Amino-N-methylphthalimide from 4-Aminophthalimide and Iodomethane

4-Amino-N-methylphthalimide Preparation Products And Raw materials

Raw materials

N,N-diprop-2-enylbenzene-1,4-dicarboxamide 1,2,4,5-Tetrazin-3-amine Benzenemethanamine, N-nitroso- 4-Nitro-N-methylphthalimide N-Methylphthalimide

4-(Methylamino)butyric acid 4-Aminophthalimide 2-hydroxy-3-methyl-1,4-naphthoquinone AZO-tert-butane dimethyl 4-aminophthalate

4-Amino-N-methylphthalimide 1H-Isoindol-1-one, 3-hydroxy- Iodomethane 4-Nitrophthalimide Dibutyl phthalate

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Preparation Products

4-Aminophthalhydrazide 5-Aminofluorescein

4-Amino-N-methylphthalimide Suppliers

Global( 215)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China Langchem Inc.	0086-21-58956006		China	7798	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Hunan Hui Bai Shi Biotechnology Co., Ltd.	0731-85526065 13308475853	ivy@hnhbsj.com	China	7236	62
BioBioPha Co., Ltd.	0871-65217109	y.liu@mail.biobiopha.com	China	5641	65
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9513	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
China Langchem Inc.	57
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Hunan Hui Bai Shi Biotechnology Co., Ltd.	62
BioBioPha Co., Ltd.	65
Shanghai Topbiochem Technology Co., Ltd	58

View Lastest Price from 4-Amino-N-methylphthalimide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-11	4-Amino-N-methylphthalimide 2307-00-8	$46.51	25Kg/Drum	98.00%HPLC	3tons/month	Asia Chem I and E (Jiangsu) Co Ltd
2026-08-25	N-Methyl-4-aminophthalimide 2307-00-8	$3.00-9.00		99%		ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2020-02-04	5-amino-2-methylisoindole-1,3-dione 2307-00-8	$1.00	1KG	98%HPLC	10tons	Career Henan Chemical Co

4-Amino-N-methylphthalimide
2307-00-8
$46.51
98.00%HPLC
Asia Chem I and E (Jiangsu) Co Ltd

N-Methyl-4-aminophthalimide
2307-00-8
$3.00-9.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

5-amino-2-methylisoindole-1,3-dione
2307-00-8
$1.00
98%HPLC
Career Henan Chemical Co

4-Amino-N-methylphthalimide Spectrum

4-AMINO-N-METHYLPHTHALIMIDE(2307-00-8)¹HNMR 4-AMINO-N-METHYLPHTHALIMIDE(2307-00-8)FT-IR 4-AMINO-N-METHYLPHTHALIMIDE(2307-00-8)IR 4-AMINO-N-METHYLPHTHALIMIDE(2307-00-8)Raman

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N-Methylphthalimide 4-Aminophthalimide AKOS 94419 4-Nitrophthalimide

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N-METHYL-4-AMINO-PHTHALIMIDE 5-amino-2-methyl-2,3-dihydro-1H-isoindole-1,3-dione IFLAB-BB F1386-0358 5-AMINO-2-METHYL-1H-ISOINDOLE-1,3(2H)-DIONE AKOS BBS-00002874 4-Amino-N-methylphthalimide 97% 4-Amino-N-methylphthalimide 4-AMINO-N-METHYLPHTHALIMIDINE N-Amino-4-nitrophthalimide 5-AMINO-2-METHYL-ISOINDOLE-1,3-DIONE 4-AMINO-N-METHYLPHTH 4-Amino-N-methylphthalimide > 1H-Isoindole-1,3(2H)-dione, 5-amino-2-methyl- 4-Amino-phthalic acid N-Methylimide dry 4-Amino-N-methylphthalimide 2307-00-8 Carbonyl Compounds Building Blocks Organic Building Blocks Cyclic Imides N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides N-Substituted Maleimides, Succinimides & Phthalimides N-Substituted Phthalimides Carbonyl Compounds Cyclic Imides Organic Building Blocks