MRS 1706
- CAS No.
- 264622-53-9
- Chemical Name:
- MRS 1706
- Synonyms
- MRS 1706;MRS-1706, 10 mM in DMSO;MRS-1706;MRS 1706;MRS1706;N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide;N-(4-ACETYLPHENYL)-2-[4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY]ACETAMIDE;N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide;Acetamide, N-(4-acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-;MRS-1706,cAMP,P1 receptor,corpus cavernosal strips,duration,inhibit,MRS 1706,Adenosine Receptor,MRS1706,Inhibitor,adenosine,magnitude
- CBNumber:
- CB7397486
- Molecular Formula:
- C27H29N5O5
- Molecular Weight:
- 503.55
- MDL Number:
- MFCD28160689
- MOL File:
- 264622-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| MRS-1706 ≥98% (HPLC) | SML3089 | 5MG | $88.4 |
| MRS-1706 ≥98% (HPLC) | SML3089 | 25MG | $356 |
| MRS1706 ≥95% | 17417 | 1mg | $36 |
| MRS1706 ≥95% | 17417 | 5mg | $120 |
| MRS1706 ≥95% | 17417 | 10mg | $203 |
| Density | 1.293±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO : 6.4 mg/mL (12.71 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble) |
| form | Powder |
| pka | 8.25±0.70(Predicted) |
| color | Off-white to yellow |
| InChIKey | ZKUCFFYOQOJLGT-UHFFFAOYSA-N |
| SMILES | O=C(COC1=CC=C(C=C1)C2=NC3=C(N2)N(C(N(C3=O)CCC)=O)CCC)NC4=CC=C(C=C4)C(C)=O |
| FDA UNII | YEE5LME5K5 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
MRS 1706 price More Price(58)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3089 | MRS-1706 ≥98% (HPLC) | 264622-53-9 | 5MG | $88.4 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML3089 | MRS-1706 ≥98% (HPLC) | 264622-53-9 | 25MG | $356 | 2026-04-30 | Buy |
| Cayman Chemical | 17417 | MRS1706 ≥95% | 264622-53-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 17417 | MRS1706 ≥95% | 264622-53-9 | 5mg | $120 | 2026-04-30 | Buy |
| Cayman Chemical | 17417 | MRS1706 ≥95% | 264622-53-9 | 10mg | $203 | 2026-04-30 | Buy |
MRS 1706 Chemical Properties,Uses,Production
Description
MRS1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.
Uses
MRS 1706 is a selective and potent Adenosine A2B-R inverse agonist Ki (binding affinity) values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.
Biological Activity
Potent and selective adenosine A 2B receptor inverse agonist (K i values are 1.39, 157, 112 and 230 nM for human A 2B , A 1 , A 2A and A 3 receptors respectively).
in vivo
MRS-1706 (1-10 μM; intracavernous injection; Ada–/– mice) reduces the magnitude and duration of electrical field stimulation (EFS)-induced contraction of corpus cavernosal strips (CCSs) from sickle cell disease (SCD) transgenic mice and inhibits the level of cAMP[2].
| Animal Model: | Ada–/– mice[2] |
| Dosage: | 1 and 10 μM |
| Administration: | Intracavernous injection |
| Result: | Inhibited A2BR signaling and reduced the magnitude and duration. Inhibited the level of cAMP. |
References
[1] YONG-CHUL KIM. Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors[J]. Journal of Medicinal Chemistry, 2000, 43 6: 1165-1172. DOI: 10.1021/jm990421v
[2] QILAN LI. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 2: 637-645. DOI: 10.1124/jpet.106.111203
MRS 1706 Preparation Products And Raw materials
Raw materials
Preparation Products
MRS 1706 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53803 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15838 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Bide Pharmatech Ltd. | 400-400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 89686 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5664 | 55 |
| Aikon International Limited | 025-58859352 19370895928 | dt3@aikonchem.com | China | 15491 | 58 |
