5-BROMO-NAPHTHALEN-1-YLAMINE
- CAS No.
- 4766-33-0
- Chemical Name:
- 5-BROMO-NAPHTHALEN-1-YLAMINE
- Synonyms
- 5-bromonaphthalen-1-amine;5-Bromo-1-naphthylamine;5-Bromo-1-naphthalenamine;1-NaphthalenaMine,5-broMo-;-BROMO-NAPHTHALEN-1-YLAMINE;5-BROMO-NAPHTHALEN-1-YLAMINE;5-Bromo-naphthalen-1-ylamine, CAS 4766-33-0
- CBNumber:
- CB7448225
- Molecular Formula:
- C10H8BrN
- Molecular Weight:
- 222.08
- MDL Number:
- MFCD07369883
- MOL File:
- 4766-33-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 55301 | 1G | $19 |
| 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 55301 | 5G | $54 |
| 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 55301 | 25G | $199 |
| 5-Bromonaphthalen-1-amine | 118148 | 5.00g | $132 |
| 5-Bromonaphthalen-1-amine | 118148 | 25.00g | $519 |
| More product size | |||
| Melting point | 66-68°C |
|---|---|
| Boiling point | 156-158 °C(Press: 1.4 Torr) |
| Density | 1.5199 (rough estimate) |
| refractive index | 1.5870 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Very Slightly) |
| form | Solid |
| pka | 3.35±0.10(Predicted) |
| color | Dark Brown to Very Dark Brown |
| InChI | InChI=1S/C10H8BrN/c11-9-5-1-4-8-7(9)3-2-6-10(8)12/h1-6H,12H2 |
| InChIKey | VNPCNUAYDOLBDR-UHFFFAOYSA-N |
| SMILES | C1(N)=C2C(C(Br)=CC=C2)=CC=C1 |
| UNSPSC Code | 12352116 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22 |
| WGK Germany | WGK 3 |
| HS Code | 2921450090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral |
5-BROMO-NAPHTHALEN-1-YLAMINE price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 55301 | 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 4766-33-0 | 1G | $19 | 2026-04-30 | Buy |
| AstaTech | 55301 | 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 4766-33-0 | 5G | $54 | 2026-04-30 | Buy |
| AstaTech | 55301 | 5-BROMO-NAPHTHALEN-1-YLAMINE 97% | 4766-33-0 | 25G | $199 | 2026-04-30 | Buy |
| Matrix Scientific | 118148 | 5-Bromonaphthalen-1-amine | 4766-33-0 | 5.00g | $132 | 2026-05-18 | Buy |
| Matrix Scientific | 118148 | 5-Bromonaphthalen-1-amine | 4766-33-0 | 25.00g | $519 | 2026-05-18 | Buy |
5-BROMO-NAPHTHALEN-1-YLAMINE Chemical Properties,Uses,Production
Uses
5-Bromonaphthalen-1-amine has inhibitory activity against KRAS G12D mutation.
Synthesis
5328-76-7
4766-33-0
Synthesis of 5-amino-1-bromonaphthalene (B): 5-nitro-1-bromonaphthalene (A) (2.5 g, 10 mmol) was dissolved in a solvent mixture of EtOH/AcOH/dioxane/H2O (2:2:2:1, 30 mL). To this solution was added iron powder (5.6 g, 100 mmol) and 2 drops of 2N HCl. The reaction mixture was stirred at 100 °C for 2 h. The reaction was completed by evaporation and removal of the solvent. After completion of the reaction, the solvent was removed by evaporation and the residue was dissolved in 100 mL of dichloromethane (DCM), washed with 5% NaHCO3 solution (3 x 30 mL) and dried over anhydrous Na2SO4. After evaporation of the solvent, the crude product was purified by silica gel column chromatography using DCM/hexane (1:1) as eluent to afford compound B as a white powder (3.0 g, 97% yield). Melting point 65-66 °C. 1H NMR (400 MHz, CDCl3) δ 7.79 (d, J = 8.8 Hz, 1H), 7.76 (d, J = 8.0 Hz, 1H), 7.71 (d, J = 8.4 Hz, 1H), 7.39 (t, J = 7.6 Hz, 1H), 7.28 (t, J = 7.2 Hz, 1H), 6.83 (d J = 7.2 Hz, 1H), 4.18 (s, 2H); 13C NMR (100 MHz, CDCl3) δ 142.5, 133.0, 130.4, 128.0, 125.1, 125.0, 123.9, 121.0, 118.4, 110.9; ESI-MS (m/z) calculated values C10H9BrN [M+ H]+ 222.0, measured value 222.1.Elemental analysis calculated values (C10H8BrN): C, 54.08; H, 3.63; N, 6.31.Measured values: C, 53.81; H, 3.46; N, 6.11.
References
[1] New Journal of Chemistry, 2005, vol. 29, # 4, p. 579 - 586
[2] Patent: US2007/274922, 2007, A1
[3] Journal of Organic Chemistry, 2017, vol. 82, # 7, p. 3873 - 3879
[4] Organic Letters, 2018, vol. 20, # 4, p. 1261 - 1264
[5] Patent: US2018/223102, 2018, A1. Location in patent: Paragraph 0260-0262
5-BROMO-NAPHTHALEN-1-YLAMINE Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3589 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| Accela ChemBio Inc. | +1-858-6993322 | info@accelachem.com | United States | 21193 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| Jinan Liheng Biotechnology Co., Ltd. | 15865262812 | info@lihengpharm.com | CHINA | 938 | 58 |
| Richest Group Ltd | 18017061086 | oled@richest-group.com | CHINA | 5600 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30225 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | sales@tnjchem.com | China | 34563 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Changzhou Guiding Bio-Tech. Co.,Ltd. | +86-519-519-86686860 +8618795626222 | ning@guiding-bio.com | China | 299 | 58 |
View Lastest Price from 5-BROMO-NAPHTHALEN-1-YLAMINE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-17 | 5-Bromonaphthalen-1-amine
4766-33-0
|
US $2.20-8.80 / kg | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2025-12-12 | 5-Bromonaphthalen-1-amine
4766-33-0
|
US $1.00-22.00 / KG | 1KG | 99% | 100000KG | Shaanxi Dideu Medichem Co. Ltd |
-
- 5-Bromonaphthalen-1-amine
4766-33-0
- US $2.20-8.80 / kg
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 5-Bromonaphthalen-1-amine
4766-33-0
- US $1.00-22.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
