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2-Acetylamino-5-bromopyridine

2-Acetylamino-5-bromopyridine Structure
2-Acetylamino-5-bromopyridine structure
CAS No.
7169-97-3
Chemical Name:
2-Acetylamino-5-bromopyridine
Synonyms
SKL873;2-ACETAMIDO-5-BROMOPYRIDINE;2-Acetylamino-5-bromopyridine;N-ACETYLAMINO-5-BROMOPYRIDINE;2-Acetamido-5-bromopyridine >N-(5-BROMO-PYRIDIN-2-YL)-ACETAMIDE;2-Acetylamino-5-bromopyridine, 98%;Acetamide, N-(5-bromo-2-pyridinyl)-;2-ACETYLAMINO-5-BROMOPYRIDINE, PURISS, 98%;JR-8242, 2-Acetylamino-5-bromopyridine, 97%
CBNumber:
CB7459508
Molecular Formula:
C7H7BrN2O
Molecular Weight:
215.05
MDL Number:
MFCD00468968
MOL File:
7169-97-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:54:58
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2-Acetylamino-5-bromopyridine Properties

Melting point 175-179 °C (lit.)
Boiling point 372.2±27.0 °C(Predicted)
Density 1.630±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
form powder to crystal
pka 12.94±0.70(Predicted)
color White to Light yellow
InChI 1S/C7H7BrN2O/c1-5(11)10-7-3-2-6(8)4-9-7/h2-4H,1H3,(H,9,10,11)
InChIKey MJFCOXATGBYERZ-UHFFFAOYSA-N
SMILES CC(=O)Nc1ccc(Br)cn1
CAS DataBase Reference 7169-97-3(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,T
Risk Statements  22-36/37/38-43-40
Safety Statements  26-36/37/39-22
WGK Germany  3
HS Code  29339900
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
NFPA 704
1
2 0

2-Acetylamino-5-bromopyridine price More Price(70)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 646407 2-Acetylamino-5-bromopyridine 98% 7169-97-3 1g $30.3 2023-01-07 Buy
Sigma-Aldrich 646407 2-Acetylamino-5-bromopyridine 98% 7169-97-3 10g $193 2023-01-07 Buy
TCI Chemical A2375 2-Acetamido-5-bromopyridine >98.0%(GC) 7169-97-3 1g $18 2026-04-30 Buy
TCI Chemical A2375 2-Acetamido-5-bromopyridine >98.0%(GC) 7169-97-3 5g $23 2026-04-30 Buy
Usbiological 261126 2-Acetylamino-5-bromopyridine Asreported 7169-97-3 5g $366 2026-06-03 Buy
Product number Packaging Price Buy
646407 1g $30.3 Buy
646407 10g $193 Buy
A2375 1g $18 Buy
A2375 5g $23 Buy
261126 5g $366 Buy

2-Acetylamino-5-bromopyridine Chemical Properties, Uses, Production

Chemical Properties

White powder

Uses

2-Acetamido-5-bromopyridine is a chemical reagent used in the synthesis of novel Bcr-Abl inhibitors with diacylated piperazine felxible linkers. Also used to produce hetero-monocyclic derivatives as even more potent inhibitors of BCR-ABL.

Synthesis

2-Amino-5-bromopyridine

1072-97-5

Acetic anhydride

108-24-7

2-ACETYLAMINO-5-BROMOPYRIDINE

7169-97-3

2-Amino-5-bromopyridine (86.50 g, 500 mmol), acetic anhydride (153 g, 1500 mmol) and 850 mL of acetic acid were added to a 2000 mL single-necked round-bottomed flask with a magnetic stirrer turned on. The reaction mixture was stirred at 100 °C for 9 hours. After confirming the complete reaction of 2-amino-5-bromopyridine by thin layer chromatography (TLC) and gas chromatography (GC) monitoring, water was added to the reaction solution. Subsequently, the reaction was filtrated and the filter cake was washed with a solvent mixture of ethyl acetate and n-hexane (1:4, v/v) to obtain the pure product 2-acetamido-5-bromopyridine. The filtrate was extracted with ethyl acetate, and the extract was concentrated by rotary evaporation to obtain the crude product, which was recrystallized with a mixed solvent of ethyl acetate and hexane (1:4, v/v) and further purified to obtain 2-acetamido-5-bromopyridine. The product was dried and the calculated yield was 75.40%, and the purity was 99.68% as determined by high performance liquid chromatography (HPLC).

References

[1] Patent: CN103601745, 2017, B. Location in patent: Paragraph 0029; 0030
[2] Tetrahedron Letters, 2002, vol. 43, # 17, p. 3121 - 3123
[3] Patent: WO2011/130628, 2011, A1. Location in patent: Page/Page column 205
[4] Patent: US2013/102595, 2013, A1. Location in patent: Paragraph 0480; 0481
[5] Patent: JP2015/187145, 2015, A. Location in patent: Paragraph 0414

2-Acetylamino-5-bromopyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-bromopyridine Acetonitrile Acetyl chloride Acetic anhydride

Preparation Products

2-Acetamidopyridine-5-boronic acid pinacol ester, 97% 2-Acetamidopyridine

2-Acetylamino-5-bromopyridine Suppliers

Global Suppliers ( 177)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
INTATRADE GmbH +49 3493/605464 sales@intatrade.de Germany 3563 66
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. +86-21-54098501 sales@sinch.com.cn China 11592 64
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
INTATRADE GmbH 66
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Capot Chemical Co., Ltd 66
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Shanghai Sinch Parmaceuticals Tech. Co. Ltd. 64

View Latest Price from 2-Acetylamino-5-bromopyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-ACETYLAMINO-5-BROMOPYRIDINE pictures 2026-08-20 2-ACETYLAMINO-5-BROMOPYRIDINE
7169-97-3
 $1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
2-Acetylamino-5-bromopyridine pictures 2020-05-13 2-Acetylamino-5-bromopyridine
7169-97-3
 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
2-ACETYLAMINO-5-BROMOPYRIDINE pictures 2020-01-15 2-ACETYLAMINO-5-BROMOPYRIDINE
7169-97-3
 $5.50 1KG 98%min 1kg-100kg Career Henan Chemical Co

2-Acetylamino-5-bromopyridine Spectrum

2-ACETYLAMINO-5-BROMOPYRIDINE(7169-97-3)1HNMR2-ACETYLAMINO-5-BROMOPYRIDINE(7169-97-3)IR

7169-97-3 (2-Acetylamino-5-bromopyridine) Related Search:

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N-ACETYLAMINO-5-BROMOPYRIDINE N-(5-BROMO-PYRIDIN-2-YL)-ACETAMIDE 2-ACETYLAMINO-5-BROMOPYRIDINE, PURISS, 98% 2-ACETAMIDO-5-BROMOPYRIDINE Acetamide, N-(5-bromo-2-pyridinyl)- JR-8242, 2-Acetylamino-5-bromopyridine, 97% 2-Acetamido-5-bromopyridine > 2-ACETYLAMINO-5-BROMOPYRIDINE ISO 9001：2015 REACH SKL873 2-Acetylamino-5-bromopyridine, 98% 2-Acetylamino-5-bromopyridine 7169-97-3 Building Blocks C8 to C9 Carbonyl Compounds Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Esters Organic Building Blocks pharmacetical Pyridine C8 to C9 Carbonyl Compounds Esters C7 and C8Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Pyridines