BMS-8
- CAS No.
- 1675201-90-7
- Chemical Name:
- BMS-8
- Synonyms
- BMS-8;BMS-8, 10 mM in DMSO;PPI,BMS 8,BMS8,inhibit,BMS-8,Inhibitor,PD-L1,PD-1;1-(3-bromo-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid , BMS-8;2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-
- CBNumber:
- CB74666331
- Molecular Formula:
- C27H28BrNO3
- Molecular Weight:
- 494.42
- MDL Number:
- MFCD31714164
- MOL File:
- 1675201-90-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 616.9±55.0 °C(Predicted) |
|---|---|
| Density | 1.334±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | Methanol: slightly soluble |
| form | A crystalline solid |
| pka | 2.35±0.20(Predicted) |
| color | White to off-white |
| InChIKey | QRXBPPWUGITQLE-UHFFFAOYSA-N |
| SMILES | N1(CC2=CC=C(OCC3C=CC=C(C4=CC=CC=C4)C=3C)C(Br)=C2)CCCCC1C(O)=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330 |
BMS-8 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22355 | BMS-8 ≥98% | 1675201-90-7 | 1mg | $29 | 2026-04-30 | Buy |
| Cayman Chemical | 22355 | BMS-8 ≥98% | 1675201-90-7 | 5mg | $135 | 2026-04-30 | Buy |
| Cayman Chemical | 22355 | BMS-8 ≥98% | 1675201-90-7 | 10mg | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 22355 | BMS-8 ≥98% | 1675201-90-7 | 25mg | $597 | 2026-04-30 | Buy |
| Cayman Chemical | 22355 | BMS-8 ≥98% | 1675201-90-7 | 500μg | $25 | 2021-12-16 | Buy |
BMS-8 Chemical Properties, Uses, Production
Description
BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay.
Uses
BMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization.
References
[1] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI: 10.1021/acs.jmedchem.7b00293
BMS-8 Preparation Products And Raw materials
Raw materials
Preparation Products
BMS-8 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 18100677375 | sales@szzxbio.com | China | 1129 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3493 | 58 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2996 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400-6387771-6039 18920764717 | sales@heowns.com | China | 24650 | 60 |
| Shandong utilizing biological technology co., LTD | 18669728830 15966937598 | 3407650895@qq.com | China | 5166 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
