AP521
- CAS No.
- 151227-08-6
- Chemical Name:
- AP521
- Synonyms
- AP521;AP521,AP-521;N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride
- CBNumber:
- CB74796632
- Molecular Formula:
- C20H19ClN2O3S
- Molecular Weight:
- 402.89
- MDL Number:
- MFCD00932423
- MOL File:
- 151227-08-6.mol
- MSDS File:
- SDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Solid |
| color | White to off-white |
| FDA UNII | NSJ3F39ZYP |
AP521 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BGA22708 | N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride | 151227-08-6 | 1mg | $606.81 | 2026-06-04 | Buy |
| Biosynth | BGA22708 | N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride | 151227-08-6 | 5mg | $1972.2 | 2026-06-04 | Buy |
| Biosynth | BGA22708 | N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride | 151227-08-6 | 10mg | $3155.4 | 2026-06-04 | Buy |
| Biosynth | BGA22708 | N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride | 151227-08-6 | 25mg | $5916.5 | 2026-06-04 | Buy |
| Biosynth | BGA22708 | N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride | 151227-08-6 | 50mg | $9466.5 | 2026-06-04 | Buy |
AP521 Chemical Properties, Uses, Production
Uses
AP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
in vivo
AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant[1].
IC 50
5-HT1A Receptor: 94 nM (IC50, in human); 5-HT1A Receptor: 135 nM (IC50, in rat); 5-HT1B Receptor: 254 nM (IC50, in rat); 5-HT1B Receptor: 5530 nM (IC50, in human); 5-HT1D Receptor: 418 nM (IC50, in human); 5-HT5A Receptor: 422 nM (IC50, in human); 5-HT7 Receptor: 198 nM (IC50, in rat)
References
[1] Kasahara K, et al. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127(1):109-16. DOI:10.1016/j.jphs.2014.11.008
AP521 Preparation Products And Raw materials
Raw materials
Preparation Products
AP521 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 1173954148q | meishipharma@126.com | China | 20027 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Supplier | Advantage |
|---|---|
| Fan De(Beijing) Biotechnology Co., Ltd. | 58 |
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| cjbscvictory | 58 |
| TargetMol Chemicals Inc. | 58 |
| Suzhou Meishi Biotechnology Co., Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| TargetMol Chemicals Inc. | 58 |
View Latest Price from AP521 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-07-16 | AP521
151227-08-6
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2026-07-15 | AP521
151227-08-6
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. | |||
 |
2025-08-22 | AP521
151227-08-6
|
$1520.00-2500.00 | 10g | TargetMol Chemicals Inc. |
