6-Methoxy-3-methyl-1H-indazole
- CAS No.
- 7746-29-4
- Chemical Name:
- 6-Methoxy-3-methyl-1H-indazole
- Synonyms
- 6-Methoxy-3-methylindazole;6-Methoxy-3-methyl-1H-indazole;3-METHYL-6-METHOXY 1H-INDAZOLE;1H-Indazole, 6-methoxy-3-methyl-
- CBNumber:
- CB7487659
- Molecular Formula:
- C9H10N2O
- Molecular Weight:
- 162.19
- MDL Number:
- MFCD07780793
- MOL File:
- 7746-29-4.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P305+P351+P338-P337+P313-P261-P271-P304+P340-P312-P403+P233-P405-P501 |
| HS Code | 2933998090 |
6-Methoxy-3-methyl-1H-indazole price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR905921 | 6-Methoxy-3-methyl-1H-indazole 98% | 7746-29-4 | 250mg | $204 | 2026-06-04 | Buy |
| Apolloscientific | OR905921 | 6-Methoxy-3-methyl-1H-indazole 98% | 7746-29-4 | 1g | $340 | 2026-06-04 | Buy |
| Matrix Scientific | 072398 | 6-Methoxy-3-methyl-1H-indazole | 7746-29-4 | 250.00mg | $324 | 2026-05-18 | Buy |
| Matrix Scientific | 072398 | 6-Methoxy-3-methyl-1H-indazole | 7746-29-4 | 1.00g | $700 | 2026-05-18 | Buy |
| Matrix Scientific | 072398 | 6-Methoxy-3-methyl-1H-indazole | 7746-29-4 | 5.00g | $1750 | 2026-05-18 | Buy |
6-Methoxy-3-methyl-1H-indazole Chemical Properties, Uses, Production
Uses
6-Methoxy-3-methyl-1H-indazole is a pharmaceutical intermediate compound that is used in the preparation of EGFR inhibitors.
Synthesis
74457-86-6
7746-29-4
General procedure for the synthesis of 6-methoxy-3-methyl-1H-indazole from 2-fluoro-4-methoxyacetophenone: 1-(2-fluoro-4-methoxyphenyl)ethan-1-one (2 g, 11.9 mmol) was dissolved in a mixture of 5 mL of hydrazine hydrate (85%) and N-methylpyrrolidone (NMP, 15 mL). The reaction mixture was stirred at 120°C for 24 hours. After completion of the reaction, the product was purified by column chromatography to afford 6-methoxy-3-methyl-1H-indazole (1.5 g, 78% yield).
References
[1] Patent: WO2016/8590, 2016, A1. Location in patent: Page/Page column 50
[2] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0365; 0366
[3] Patent: US6956036, 2005, B1
[4] Patent: US6552062, 2003, B1
[5] Patent: WO2009/144554, 2009, A1. Location in patent: Page/Page column 49-50
6-Methoxy-3-methyl-1H-indazole Preparation Products And Raw materials
Raw materials
Preparation Products
6-Methoxy-3-methyl-1H-indazole Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Devinchem Ltd | 027-65318838 13646286950 | sales@devinchem.com | China | 2983 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Cool Pharm, Ltd | 021-60455363 18019463053 | sales@coolpharm.com | China | 8455 | 58 |
| Bellen Chemistry Co., Ltd. | 010-60400365-8001 15910885229 | service@bellenchem.com | China | 4514 | 60 |
| JW & Y Pharmlab Co., Ltd. | 021-64340559 | xinyu_shi@jwypharmlab.com.cn | China | 11999 | 58 |
| Shanghai Kahn Pharmaceutical Co., Ltd. | 021-34979681; 17701870669 | 41513101@qq.com | China | 1788 | 55 |
| SuZhou ShiYa Biopharmaceuticals, Inc. | 0512-0512-52358471 17715136450 | sales@shiyabiopharm.com | China | 9814 | 58 |
| Shanghai Brain Biotechnology Co., Ltd. | 13564638271 | shhjiang1977@163.com | China | 2983 | 55 |
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