2-Fluoro-4-methoxyacetophenone
- CAS No.
- 74457-86-6
- Chemical Name:
- 2-Fluoro-4-methoxyacetophenone
- Synonyms
- 1-(2-fluoro-4-Methoxyphenyl)ethan-1-one;4-ACETYL-3-FLUOROANISOLE;4-Methoxyphenacyl fluoride;2-fluor-4-methoxyacetophenone;2'-Fluoro-4'-Methoxyacetoph...;2-FLUORO-4-METHXOYACETOPHENONE;2-FLUORO-4-METHOXYACETOPHENONE;2'-Fluoro-4'-methoxyacetophenone;2'-Fluoro-4'-methoxylacetophenone;2'-Fluoro-4'-methoxyacetophenone99%
- CBNumber:
- CB8711968
- Molecular Formula:
- C9H9FO2
- Molecular Weight:
- 168.17
- MDL Number:
- MFCD00042290
- MOL File:
- 74457-86-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 52-54 °C(lit.) |
|---|---|
| Boiling point | 80-85 °C (0.1 mmHg) |
| Density | 1.1410 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| form | Viscous Solution |
| color | Clear colorless |
| Water Solubility | Insoluble |
| BRN | 3539992 |
| InChI | 1S/C9H9FO2/c1-6(11)8-4-3-7(12-2)5-9(8)10/h3-5H,1-2H3 |
| InChIKey | PIRRWUMTIBFCCW-UHFFFAOYSA-N |
| SMILES | COc1ccc(C(C)=O)c(F)c1 |
| CAS DataBase Reference | 74457-86-6(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29147000 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Fluoro-4-methoxyacetophenone price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 331686 | 2′-Fluoro-4′-methoxyacetophenone 99% | 74457-86-6 | 5g | $56.1 | 2023-06-20 | Buy |
| TCI Chemical | F0662 | 2'-Fluoro-4'-methoxyacetophenone >98.0%(GC) | 74457-86-6 | 1g | $37 | 2026-04-30 | Buy |
| TCI Chemical | F0662 | 2'-Fluoro-4'-methoxyacetophenone >98.0%(GC) | 74457-86-6 | 5g | $59 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0078 | 2'-Fluoro-4'- methoxyacetophenone, min. 98% min.98% | 74457-86-6 | 25g | $40 | 2026-04-30 | Buy |
| Strem Chemicals | 09-0078 | 2'-Fluoro-4'- methoxyacetophenone, min. 98% min.98% | 74457-86-6 | 100g | $96 | 2026-04-30 | Buy |
2-Fluoro-4-methoxyacetophenone Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
2′-Fluoro-4′-methoxyacetophenone may be used in chemical synthesis.
Preparation
Obtained by reaction of acetic anhydride with 3-fluoroanisole in the presence of aluminium chloride in carbon disulfide at r.t., then at 30–35° until no more hydrochloric acid is evolved.
Synthesis
1313430-15-7
74457-86-6
3-Fluoro-4-methoxyacetophenone oxime ether (39.4 mg, 0.2 mmol) was dissolved in 2 mL of ether, 37% hydrochloric acid was added and the reaction was stirred for 30 h at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction solution was neutralized with saturated sodium carbonate solution to pH 7, followed by extraction of the mixture with ether (10 mL × 3). The organic phases were combined, dried with anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. The crude product was purified by column chromatography (eluent ratio: petroleum ether/ethyl acetate = 20:1, v/v), and the eluent containing the target product was collected, and the solvent was removed by distillation under reduced pressure to afford 2-fluoro-4-methoxyacetophenone (26.5 mg, 79% yield).
References
[1] Patent: CN103922904, 2016, B. Location in patent: Paragraph 0058; 0059; 0062
2-Fluoro-4-methoxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Lastest Price from 2-Fluoro-4-methoxyacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 2-Fluoro-4-methoxyacetophenone
74457-86-6
|
1KG | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-04-04 | 2-Fluoro-4-methoxyacetophenone
74457-86-6
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2020-01-08 | 2-Fluoro-4-methoxyacetophenone
74457-86-6
|
1KG | 98%； 99% | 1kg; 5kg; 10kg；25kg | Career Henan Chemical Co |
-
- 2-Fluoro-4-methoxyacetophenone
74457-86-6
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-Fluoro-4-methoxyacetophenone
74457-86-6
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 2-Fluoro-4-methoxyacetophenone
74457-86-6
- $0.01
- 98%； 99%
- Career Henan Chemical Co
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