4-Methoxy-3-pyridinecarboxaldehyde
- CAS No.
- 82257-15-6
- Chemical Name:
- 4-Methoxy-3-pyridinecarboxaldehyde
- Synonyms
- 4-Methoxynicotinaldehyde;4-Methoxypyridine-3-carbaldehyde;4-MethoxynicotinaL;3-FORMYL-4-METHOXYPYRIDINE;4-METHOXY-PYRIDINE-3-CARBALDEHYE;4-Methoxy-3-carboxaldehydepyridine;4-METHOXYPYRIDINE-3-CARBOXALDEHYDE;4-METHOXY-3-PYRIDINE CARBOXALDEHYDE;3-Pyridinecarboxaldehyde, 4-Methoxy-;3-Pyridinecarboxaldehyde, 4-methoxy- (9CI)
- CBNumber:
- CB7488696
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD04112505
- MOL File:
- 82257-15-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 63-67°C |
|---|---|
| Boiling point | 262.9±20.0 °C(Predicted) |
| Density | 1.159±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| pka | 4.75±0.18(Predicted) |
| Appearance | White to yellow Solid |
| CAS DataBase Reference | 82257-15-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H320-H226 |
| Precautionary statements | P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P303+P361+P353-P403+P235 |
| Hazard Codes | Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
4-Methoxy-3-pyridinecarboxaldehyde price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 277726 | 3-Formyl-4-methoxypyridine Asreported | 82257-15-6 | 100mg | $375 | 2026-06-03 | Buy |
| Usbiological | 277726 | 3-Formyl-4-methoxypyridine Asreported | 82257-15-6 | 250mg | $475 | 2026-06-03 | Buy |
| Usbiological | 277726 | 3-Formyl-4-methoxypyridine Asreported | 82257-15-6 | 500mg | $638 | 2026-06-03 | Buy |
| Usbiological | 277726 | 3-Formyl-4-methoxypyridine Asreported | 82257-15-6 | 1g | $1084 | 2026-06-03 | Buy |
| Usbiological | 277726 | 3-Formyl-4-methoxypyridine Asreported | 82257-15-6 | 2g | $1529 | 2026-06-03 | Buy |
4-Methoxy-3-pyridinecarboxaldehyde Chemical Properties, Uses, Production
Chemical Properties
light yellow solid
Uses
4-Methoxypyridine-3-carboxaldehyde, is an intermediate for the synthesis of 4-Hydroxy-3-pyridinecarboxylic Acid (H952780). It can also be used for the preparation of 7,8-dimethylquinolines derivatives as potential antimicrobial and antifungal agents.
Synthesis
620-08-6
68-12-2
82257-15-6
Example 2 Preparation of 4-methoxypyridine-3-carbaldehyde To a stirred solution of tetrahydrofuran (380 mL) was added tert-butyllithium (90.6 mL, 154 mmol; 1.7 M in pentane) via cannula under nitrogen protection. The reaction mixture was cooled to -78°C, followed by dropwise addition of 2-bromotoluene (11.3 mL, 74.1 mmol). The reaction mixture was stirred at -78°C for 1 hour. Then, 4-methoxypyridine (5.79 mL, 57 mmol) was added dropwise to the reaction mixture at -78°C and the resulting mixture was stirred at -23°C for 3 hours. The reaction mixture was again cooled to -78°C, N,N-dimethylformamide (6.62 mL, 85.5 mmol) was added and stirring was continued at -78°C for 1 hour. The reaction mixture was slowly quenched with saturated aqueous sodium chloride solution (100 mL) at -78°C, followed by slow warming to room temperature. Ether (200 mL) was added to the reaction mixture and the organic and aqueous layers were separated. The aqueous layer was extracted with ether (2 x 150 mL) and the combined organic layers were dried with anhydrous potassium carbonate (20 g). The potassium carbonate was removed by filtration, the filter cake was washed with ether (100 mL), and the solvent was removed by concentration under reduced pressure. The resulting crude product, 4-methoxy-3-pyridinecarboxaldehyde, was purified by silica gel column chromatography (eluent ratio 5:95 ethanol:ethyl acetate) to afford 4.79 g of the target product as a yellow solid (61% yield; purity >98% as determined by 1H NMR).
References
[1] Tetrahedron Letters, 2006, vol. 47, # 1, p. 39 - 41
[2] Tetrahedron Letters, 2000, vol. 41, # 24, p. 4777 - 4780
[3] Patent: WO2005/42514, 2005, A2. Location in patent: Page/Page column 25
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 1, p. 419 - 434
[5] Journal of Organic Chemistry, 1990, vol. 55, # 1, p. 69 - 73
4-Methoxy-3-pyridinecarboxaldehyde Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Heterochem | 027-88041443 13072715837 | sales@hetero-chem.com | China | 695 | 58 |
| Baiyin Chengze Chemical Technology Co., Ltd. | +86 943-8535351 13389336721 | sales@chengzechem.com | China | 300 | 58 |
View Latest Price from 4-Methoxy-3-pyridinecarboxaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Methoxy-3-pyridinecarboxaldehyde
82257-15-6
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2019-12-26 | 4-Methoxy-3-pyridinecarboxaldehyde
82257-15-6
|
$2.00 | 1KG | 98%MIN | Career Henan Chemical Co |
-
- 4-Methoxy-3-pyridinecarboxaldehyde
82257-15-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Methoxy-3-pyridinecarboxaldehyde
82257-15-6
- $2.00
- 98%MIN
- Career Henan Chemical Co
