ELA-14 (human)
- CAS No.
- 1886973-05-2
- Chemical Name:
- ELA-14 (human)
- Synonyms
- Elabela(19-32);ELA-14 (human);Glp-RRCMPLHSRVPFP;ELA-14 (human) TFA;Elabela(19-32)、ELA-14 (human);L-Proline, 5-oxo-L-prolyl-L-arginyl-L-arginyl-L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl-
- CBNumber:
- CB74902716
- Molecular Formula:
- C75H119N25O17S2
- Molecular Weight:
- 1707.03
- MDL Number:
- MFCD31382540
- MOL File:
- 1886973-05-2.mol
ELA-14 (human) Chemical Properties,Uses,Production
Uses
Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1].
in vivo
Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t1/2<2 min)[1].
References
[1] Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72. DOI:10.1021/acs.jmedchem.5b01549
ELA-14 (human) Preparation Products And Raw materials
Raw materials
Preparation Products
ELA-14 (human) Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
Nanjing TGpeptide | +86-13347807150 +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5221 | 58 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 17801761073 | 3193328036@qq.com | China | 29763 | 68 |
Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | Caroline@youngshechem.com | China | 4803 | 58 |
Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 | Eric@peptidego.com | China | 7061 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
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