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| | ELA-14 (human) Basic information |
| Product Name: | ELA-14 (human) | | Synonyms: | ELA-14 (human);L-Proline, 5-oxo-L-prolyl-L-arginyl-L-arginyl-L-cysteinyl-L-methionyl-L-prolyl-L-leucyl-L-histidyl-L-seryl-L-arginyl-L-valyl-L-prolyl-L-phenylalanyl-;Elabela(19-32);Glp-RRCMPLHSRVPFP;ELA-14 (human) TFA;Elabela(19-32)、ELA-14 (human) | | CAS: | 1886973-05-2 | | MF: | C75H119N25O17S2 | | MW: | 1707.03 | | EINECS: | | | Product Categories: | | | Mol File: | 1886973-05-2.mol |  |
| | ELA-14 (human) Chemical Properties |
| form | Solid | | color | White to off-white |
| | ELA-14 (human) Usage And Synthesis |
| Uses | Elabela(19-32) is an active fragment of ELABELA (ELA) that binds to apelin receptor (APJ). Elabela(19-32) activates the Gαi1 and β-arrestin-2 signaling pathways with EC50s of 8.6 nM and 166 nM. Elabela(19-32) induces receptor internalization and reduces arterial pressure, exerts positive inotropic effects on the heart[1]. | | in vivo | Elabela(19-32) (analogue 3) is rapidly metabolized in rat plasma (t1/2<2 min)[1].
| | References | [1] Alexandre Murza, et al. Discovery and Structure-Activity Relationship of a Bioactive Fragment of ELABELA That Modulates Vascular and Cardiac Functions. J Med Chem. 2016 Apr 14;59(7):2962-72. DOI:10.1021/acs.jmedchem.5b01549 |
| | ELA-14 (human) Preparation Products And Raw materials |
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