FR-167356
- CAS No.
- 174185-16-1
- Chemical Name:
- FR-167356
- Synonyms
- FR-167356;Benzamide, 2,6-dichloro-N-[3-(1-hydroxy-1-methylethyl)-2-methyl-7-benzofuranyl]-
- CBNumber:
- CB74919804
- Molecular Formula:
- C19H17Cl2NO3
- Molecular Weight:
- 378.25
- MDL Number:
- MOL File:
- 174185-16-1.mol
- MSDS File:
- SDS
| Boiling point | 422.7±40.0 °C(Predicted) |
|---|---|
| Density | 1.385±0.06 g/cm3(Predicted) |
| pka | 11+-.0.43(Predicted) |
| FDA UNII | XF02B1HC8R |
FR-167356 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0082573 | FR-167356 | 174185-16-1 | 1mg | $606 | 2026-06-04 | Buy |
| aablocks | AA024C9R | FR-167356 | 174185-16-1 | 1mg | $115 | 2026-06-01 | Buy |
| aablocks | AA024C9R | FR-167356 | 174185-16-1 | 5mg | $250 | 2026-06-01 | Buy |
| aablocks | AA024C9R | FR-167356 | 174185-16-1 | 10mg | $334 | 2026-06-01 | Buy |
| aablocks | AA024C9R | FR-167356 | 174185-16-1 | 25mg | $495 | 2026-06-01 | Buy |
FR-167356 Chemical Properties, Uses, Production
Uses
FR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].
in vivo
FR-167356 (200 mg/kg; p.o.; daily, for 10 days; male C57BL/6 mice with B16-F10 xenografts) inhibits tumor growth and reduces MMP9 expression[1].
FR-167356 (200 mg/kg; p.o.; daily, for 10 days; male C57BL/6 mice with B16-F10 xenografts) reduces bone metastasis compared to untreated group[1].
| Animal Model: | male C57BL/6 mice with B16-F10 xenografts[1] |
| Dosage: | 200 mg/kg |
| Administration: | Oral administration; daily, for 10 days |
| Result: | Reduced the expression of MMP9 and reduced bone metastasis. |
References
[1] Nishisho T, et, al. The a3 isoform vacuolar type H-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55. DOI:10.1158/1541-7786.MCR-10-0449
[2] Niikura K, et, al. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. J Bone Miner Res. 2005 Sep;20(9):1579-88. DOI:10.1359/JBMR.050517
FR-167356 Preparation Products And Raw materials
Raw materials
Preparation Products
FR-167356 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 13370042665 18916960931 | 2596183085@qq.com | China | 17234 | 58 |
| Supplier | Advantage |
|---|---|
| BOC Sciences | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| Shanghai Amole Biotechnology Co., Ltd. | 58 |
