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Rac 8-hydroxy efavirenz

Rac 8-hydroxy efavirenz structure

CAS No.: 205754-33-2

Chemical Name:: Rac 8-hydroxy efavirenz

Synonyms: 8-HydroxyEfavirenz;Rac 8-hydroxy efavirenz;8-hydroxy Efavirenz (Standard);8-Hydroxyefavirenz/205754-33-2;Efavirenz Impurity 11(8-Hydroxy Efavirenz);(4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one;6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one;2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-;(S)-6-Chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one;2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)-

CBNumber:: CB7501021

Molecular Formula:: C14H9ClF3NO3

Molecular Weight:: 331.67

MDL Number:: MFCD09840726

MOL File:: 205754-33-2.mol

MSDS File:: SDS

Last updated:2026-09-12 18:54:59

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Rac 8-hydroxy efavirenz Properties

Melting point	144-154°C
Boiling point	373.6±42.0 °C(Predicted)
Density	1+-.0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Acetonitrile: soluble; DMSO: soluble; Methanol: soluble
form	A solid
pka	7.18±0.40(Predicted)
color	White to off-white
InChI	InChI=1S/C14H9ClF3NO3/c15-8-5-9-11(10(20)6-8)19-12(21)22-13(9,14(16,17)18)4-3-7-1-2-7/h5-7,20H,1-2H2,(H,19,21)/t13-/m0/s1
InChIKey	OOVOMPCQLMFEDT-ZDUSSCGKSA-N
SMILES	N1C2=C(O)C=C(Cl)C=C2[C@@](C#CC2CC2)(C(F)(F)F)OC1=O
FDA UNII	P8S49CKH6L

Rac 8-hydroxy efavirenz price More Price(29)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27853	8-hydroxy Efavirenz ≥98%	205754-33-2	1mg	$666	2026-04-30	Buy
Usbiological	440145	8-Hydroxy Efavirenz (~90%) ~90%	205754-33-2	100ug	$602	2026-06-03	Buy
Usbiological	440145	8-Hydroxy Efavirenz (~90%) ~90%	205754-33-2	500ug	$2442	2026-06-03	Buy
Biosynth	FIA75433	8-Hydroxy efavirenz	205754-33-2	1mg	$1963.94	2026-06-04	Buy
ChemScene	CS-0138367	8-Hydroxyefavirenz 97.01%	205754-33-2	1mg	$628	2026-06-04	Buy

Product number	Packaging	Price	Buy
27853	1mg	$666	Buy
440145	100ug	$602	Buy
440145	500ug	$2442	Buy
FIA75433	1mg	$1963.94	Buy
CS-0138367	1mg	$628	Buy

Rac 8-hydroxy efavirenz Chemical Properties, Uses, Production

Description

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B6. It induces apoptosis in rat primary hippocampal neurons and loss of dendritic spines in rat primary hippocampal neuronal cultures when used at a concentration of 0.01 μM.

Chemical Properties

Off-White Solid

Uses

A labellebed metabolite of Efavirenz, a nonnucleoside HIV-1 reverse transcriptase inhibitor

Uses

8-Hydroxy Efavirenz is a metabolite of Efavirenz (E425000), a nonnucleoside HIV-1 reverse transcriptase inhibitor.

References

[1] ERIC H DECLOEDT G M. Neuronal toxicity of efavirenz: a systematic review.[J]. Expert Opinion on Drug Safety, 2013, 12 6: 841-846. DOI: 10.1517/14740338.2013.823396
[2] LUIS B TOVAR-Y ROMO. Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.[J]. Journal of Pharmacology and Experimental Therapeutics, 2012, 343 3: 696-703. DOI: 10.1124/jpet.112.195701

Rac 8-hydroxy efavirenz Preparation Products And Raw materials

Raw materials

Preparation Products

Rac 8-hydroxy efavirenz Suppliers

Global Suppliers ( 46)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Devinchem Ltd	027-65318838 13646286950	sales@devinchem.com	China	2983	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
BOC Sciences	16314854226	info@bocsci.com	United States	9909	65
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9799	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6705	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	57336	58
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Guangzhou Dreampharm Biotechnology Co., Ltd.	020-36607679; 13502246435	3008233746@qq.com	China	9953	12

Supplier	Advantage
Shanghai Devinchem Ltd	58
J & K SCIENTIFIC LTD.	76
Chemsky (shanghai) International Co.,Ltd	60
BOC Sciences	65
Shanghai EFE Biological Technology Co., Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
BOC Sciences	58
TargetMol Chemicals Inc.	58
Guangzhou Dreampharm Biotechnology Co., Ltd.	12

View Latest Price from Rac 8-hydroxy efavirenz manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	8-hydroxy Efavirenz 205754-33-2	$1510.00			10g	TargetMol Chemicals Inc.

8-hydroxy Efavirenz
205754-33-2
$1510.00
TargetMol Chemicals Inc.

205754-33-2 (Rac 8-hydroxy efavirenz) Related Search:

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8-HydroxyEfavirenz 6-Chloro-4-(cyclopropyl-d4-ethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one (4S)-6-chloro-4-(2-cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1H-3,1-benzoxazin-2-one Efavirenz Impurity 11(8-Hydroxy Efavirenz) 2H-3,1-Benzoxazin-2-one, 6-chloro-4-(2-cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)- 8-Hydroxy EfavirenzQ: What is 8-Hydroxy Efavirenz Q: What is the CAS Number of 8-Hydroxy Efavirenz Q: What is the storage condition of 8-Hydroxy Efavirenz Q: What are the applications of 8-Hydroxy Efavirenz 2H-3,1-Benzoxazin-2-one,6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-8-hydroxy-4-(trifluoromethyl)-, (4S)- (S)-6-Chloro-4-(cyclopropylethynyl)-8-hydroxy-4-(trifluoromethyl)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one 8-Hydroxyefavirenz/205754-33-2 8-hydroxy Efavirenz (Standard) Rac 8-hydroxy efavirenz 205754-33-2 Intermediates & Fine Chemicals Isotope Labeled Compounds Metabolites Non-nucleoside Reverse Transcriptase Pharmaceuticals